Conference Paper: Mesenchymal stromal cells rescue disc degeneration and function via suppression of fibrotic events

TitleMesenchymal stromal cells rescue disc degeneration and function via suppression of fibrotic events
Authors
Issue Date2011
Citation
The 2011 Meeting of the Days of Molecular Medicine (DMM), Hong Kong, 10-12 November 2011. How to Cite?
AbstractChronic back pain and neuropathological conditions such as spondylomyelopathy and radiculopathy are associated with degeneration of the intervertebral discs in spinal column. Human and animal studies imply a role of fibrosis in the degeneration process. Mesenchymal stromal cells (MSCs) possess anti-fibrotic activities. We investigated if MSCs elicit disc regeneration through modulating fibrotic events. Skeletally mature rabbits with injury-induced lumbar disc degeneration were randomized to receive intradiscal engraftment of bone marrow-derived MSCs or control vehicle. Disc degeneration status was evaluated by MRI and radiographs. We showed that MSCs regenerated the disc along with a recovery …
DescriptionDMM 2011 entitled: Re-engineering Regenerative Medicine
Poster Session - Orthopedic Regeneration: no. 92
Persistent Identifierhttp://hdl.handle.net/10722/165098

 

DC FieldValueLanguage
dc.contributor.authorLeung, VYLen_US
dc.contributor.authorAladin, KDMen_US
dc.contributor.authorLv, Fen_US
dc.contributor.authorTam, Ven_US
dc.contributor.authorSun, Yen_US
dc.contributor.authorTang, Ben_US
dc.contributor.authorNgan, AHWen_US
dc.contributor.authorLim, CTen_US
dc.contributor.authorWu, EXen_US
dc.contributor.authorLuk, KDKen_US
dc.contributor.authorChan, D-
dc.contributor.authorLu, WW-
dc.contributor.authorCheung, KMC-
dc.date.accessioned2012-09-20T08:14:45Z-
dc.date.available2012-09-20T08:14:45Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2011 Meeting of the Days of Molecular Medicine (DMM), Hong Kong, 10-12 November 2011.en_US
dc.identifier.urihttp://hdl.handle.net/10722/165098-
dc.descriptionDMM 2011 entitled: Re-engineering Regenerative Medicine-
dc.descriptionPoster Session - Orthopedic Regeneration: no. 92-
dc.description.abstractChronic back pain and neuropathological conditions such as spondylomyelopathy and radiculopathy are associated with degeneration of the intervertebral discs in spinal column. Human and animal studies imply a role of fibrosis in the degeneration process. Mesenchymal stromal cells (MSCs) possess anti-fibrotic activities. We investigated if MSCs elicit disc regeneration through modulating fibrotic events. Skeletally mature rabbits with injury-induced lumbar disc degeneration were randomized to receive intradiscal engraftment of bone marrow-derived MSCs or control vehicle. Disc degeneration status was evaluated by MRI and radiographs. We showed that MSCs regenerated the disc along with a recovery …-
dc.languageengen_US
dc.relation.ispartofDay of Molecular Medicine, DMM 2011en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleMesenchymal stromal cells rescue disc degeneration and function via suppression of fibrotic eventsen_US
dc.typeConference_Paperen_US
dc.identifier.emailLeung, VYL: vicleung@hku.hken_US
dc.identifier.emailTam, V: vivtam@hku.hken_US
dc.identifier.emailNgan, AHW: hwngan@hkucc.hku.hken_US
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_US
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_US
dc.identifier.emailChan, D: chand@hku.hken_US
dc.identifier.emailLu, WW: wwlu@hku.hk-
dc.identifier.emailCheung, KMC: cheungmc@hku.hk-
dc.identifier.authorityLeung, VYL=rp01764en_US
dc.identifier.authorityTang, B=rp00081en_US
dc.identifier.authorityNgan, AHW=rp00225en_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.identifier.authorityLuk, KDK=rp00333en_US
dc.description.naturepostprint-
dc.identifier.hkuros210487en_US

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