Supplementary

Conference Paper: Mesenchymal stromal cells rescue disc degeneration and function via suppression of fibrotic events
  • Basic View
  • Metadata View
  • XML View
TitleMesenchymal stromal cells rescue disc degeneration and function via suppression of fibrotic events
 
AuthorsLeung, VYL
Aladin, KDM
Lv, F
Tam, V
Sun, Y
Tang, B
Ngan, AHW
Lim, CT
Wu, EX
Luk, KDK
Chan, D
Lu, WW
Cheung, KMC
 
Issue Date2011
 
CitationThe 2011 Meeting of the Days of Molecular Medicine (DMM), Hong Kong, 10-12 November 2011. [How to Cite?]
 
AbstractChronic back pain and neuropathological conditions such as spondylomyelopathy and radiculopathy are associated with degeneration of the intervertebral discs in spinal column. Human and animal studies imply a role of fibrosis in the degeneration process. Mesenchymal stromal cells (MSCs) possess anti-fibrotic activities. We investigated if MSCs elicit disc regeneration through modulating fibrotic events. Skeletally mature rabbits with injury-induced lumbar disc degeneration were randomized to receive intradiscal engraftment of bone marrow-derived MSCs or control vehicle. Disc degeneration status was evaluated by MRI and radiographs. We showed that MSCs regenerated the disc along with a recovery …
 
DescriptionDMM 2011 entitled: Re-engineering Regenerative Medicine
Poster Session - Orthopedic Regeneration: no. 92
 
DC FieldValue
dc.contributor.authorLeung, VYL
 
dc.contributor.authorAladin, KDM
 
dc.contributor.authorLv, F
 
dc.contributor.authorTam, V
 
dc.contributor.authorSun, Y
 
dc.contributor.authorTang, B
 
dc.contributor.authorNgan, AHW
 
dc.contributor.authorLim, CT
 
dc.contributor.authorWu, EX
 
dc.contributor.authorLuk, KDK
 
dc.contributor.authorChan, D
 
dc.contributor.authorLu, WW
 
dc.contributor.authorCheung, KMC
 
dc.date.accessioned2012-09-20T08:14:45Z
 
dc.date.available2012-09-20T08:14:45Z
 
dc.date.issued2011
 
dc.description.abstractChronic back pain and neuropathological conditions such as spondylomyelopathy and radiculopathy are associated with degeneration of the intervertebral discs in spinal column. Human and animal studies imply a role of fibrosis in the degeneration process. Mesenchymal stromal cells (MSCs) possess anti-fibrotic activities. We investigated if MSCs elicit disc regeneration through modulating fibrotic events. Skeletally mature rabbits with injury-induced lumbar disc degeneration were randomized to receive intradiscal engraftment of bone marrow-derived MSCs or control vehicle. Disc degeneration status was evaluated by MRI and radiographs. We showed that MSCs regenerated the disc along with a recovery …
 
dc.description.naturepostprint
 
dc.descriptionDMM 2011 entitled: Re-engineering Regenerative Medicine
 
dc.descriptionPoster Session - Orthopedic Regeneration: no. 92
 
dc.identifier.citationThe 2011 Meeting of the Days of Molecular Medicine (DMM), Hong Kong, 10-12 November 2011. [How to Cite?]
 
dc.identifier.hkuros210487
 
dc.identifier.urihttp://hdl.handle.net/10722/165098
 
dc.languageeng
 
dc.relation.ispartofDay of Molecular Medicine, DMM 2011
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.titleMesenchymal stromal cells rescue disc degeneration and function via suppression of fibrotic events
 
dc.typeConference_Paper
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Leung, VYL</contributor.author>
<contributor.author>Aladin, KDM</contributor.author>
<contributor.author>Lv, F</contributor.author>
<contributor.author>Tam, V</contributor.author>
<contributor.author>Sun, Y</contributor.author>
<contributor.author>Tang, B</contributor.author>
<contributor.author>Ngan, AHW</contributor.author>
<contributor.author>Lim, CT</contributor.author>
<contributor.author>Wu, EX</contributor.author>
<contributor.author>Luk, KDK</contributor.author>
<contributor.author>Chan, D</contributor.author>
<contributor.author>Lu, WW</contributor.author>
<contributor.author>Cheung, KMC</contributor.author>
<date.accessioned>2012-09-20T08:14:45Z</date.accessioned>
<date.available>2012-09-20T08:14:45Z</date.available>
<date.issued>2011</date.issued>
<identifier.citation>The 2011 Meeting of the Days of Molecular Medicine (DMM), Hong Kong, 10-12 November 2011.</identifier.citation>
<identifier.uri>http://hdl.handle.net/10722/165098</identifier.uri>
<description>DMM 2011 entitled: Re-engineering Regenerative Medicine</description>
<description>Poster Session - Orthopedic Regeneration: no. 92</description>
<description.abstract>Chronic back pain and neuropathological conditions such as spondylomyelopathy and radiculopathy are associated with degeneration of the intervertebral discs in spinal column. Human and animal studies imply a role of fibrosis in the degeneration process. Mesenchymal stromal cells (MSCs) possess anti-fibrotic activities. We investigated if MSCs elicit disc regeneration through modulating fibrotic events. Skeletally mature rabbits with injury-induced lumbar disc degeneration were randomized to receive intradiscal engraftment of bone marrow-derived MSCs or control vehicle. Disc degeneration status was evaluated by MRI and radiographs. We showed that MSCs regenerated the disc along with a recovery &#8230;</description.abstract>
<language>eng</language>
<relation.ispartof>Day of Molecular Medicine, DMM 2011</relation.ispartof>
<rights>Creative Commons: Attribution 3.0 Hong Kong License</rights>
<title>Mesenchymal stromal cells rescue disc degeneration and function via suppression of fibrotic events</title>
<type>Conference_Paper</type>
<description.nature>postprint</description.nature>
<identifier.hkuros>210487</identifier.hkuros>
<bitstream.url>http://hub.hku.hk/bitstream/10722/165098/1/Abstract.pdf</bitstream.url>
</item>