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Conference Paper: Cadherin 2 as human notochordal cell marker and its expression pattern in disc degeneration

TitleCadherin 2 as human notochordal cell marker and its expression pattern in disc degeneration
Authors
Issue Date2012
PublisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.com/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=1351&category_id=90&option=com_virtuemart&Itemid=53
Citation
The World Forum for Spine Research (WFSR 2012): The Intervertebral Disc - from Degeneration to Pain, Helsinki, Finland, 18-21 June 2012. In Global Spine Journal, 2012, v. 2 n. S1, no. P46 How to Cite?
AbstractINTRODUCTION: Cadherins are transmembrane glycoproteins that mediate calcium-dependent cell adhesion. Recent studies suggest that cadherins also have nonadhesive functions. Maturation of human intervertebral disk (IVD) as well as early events of IVD degeneration in a mouse model1 is associated with segregation of nucleus pulposus (NP) cells suggesting that disk degeneration may be associated with cell adhesion molecule activities. From our microarray data analysis and subsequent immunohistochemical assays, we have revealed specific expression of Cdh2 gene and its product, cadherin 2/N-cadherin, in rodent notochordal NP cells, suggesting a potential regulatory role of cadherins in IVD homeostasis. Cadherin 2 belongs to the classic cadherin family. To date, the exp...
Persistent Identifierhttp://hdl.handle.net/10722/165097
ISSN
2015 SCImago Journal Rankings: 0.108

 

DC FieldValueLanguage
dc.contributor.authorLim, FLen_US
dc.contributor.authorCheung, KMCen_US
dc.contributor.authorChan, Den_US
dc.contributor.authorTuan, RSen_US
dc.contributor.authorLeung, VYLen_US
dc.date.accessioned2012-09-20T08:14:44Z-
dc.date.available2012-09-20T08:14:44Z-
dc.date.issued2012en_US
dc.identifier.citationThe World Forum for Spine Research (WFSR 2012): The Intervertebral Disc - from Degeneration to Pain, Helsinki, Finland, 18-21 June 2012. In Global Spine Journal, 2012, v. 2 n. S1, no. P46en_US
dc.identifier.issn2192-5682-
dc.identifier.urihttp://hdl.handle.net/10722/165097-
dc.description.abstractINTRODUCTION: Cadherins are transmembrane glycoproteins that mediate calcium-dependent cell adhesion. Recent studies suggest that cadherins also have nonadhesive functions. Maturation of human intervertebral disk (IVD) as well as early events of IVD degeneration in a mouse model1 is associated with segregation of nucleus pulposus (NP) cells suggesting that disk degeneration may be associated with cell adhesion molecule activities. From our microarray data analysis and subsequent immunohistochemical assays, we have revealed specific expression of Cdh2 gene and its product, cadherin 2/N-cadherin, in rodent notochordal NP cells, suggesting a potential regulatory role of cadherins in IVD homeostasis. Cadherin 2 belongs to the classic cadherin family. To date, the exp...-
dc.languageengen_US
dc.publisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.com/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=1351&category_id=90&option=com_virtuemart&Itemid=53-
dc.relation.ispartofGlobal Spine Journalen_US
dc.rightsGlobal Spine Journal. Copyright © Georg Thieme Verlag.-
dc.titleCadherin 2 as human notochordal cell marker and its expression pattern in disc degenerationen_US
dc.typeConference_Paperen_US
dc.identifier.emailLim, FL: h0894164@HKUSUC.hku.hken_US
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_US
dc.identifier.emailChan, D: chand@hku.hken_US
dc.identifier.emailLeung, VYL: vicleung@hku.hk-
dc.identifier.authorityCheung, KMC=rp00387en_US
dc.identifier.authorityChan, D=rp00540en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1055/s-0032-1319925-
dc.identifier.hkuros210484en_US
dc.identifier.volume2-
dc.identifier.issueS1, no. P46-
dc.publisher.placeGermany-
dc.customcontrol.immutablesml 130320-

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