File Download

Conference Paper: Roles of perineuronal matrix in developmental plasticity of the central vestibular system

TitleRoles of perineuronal matrix in developmental plasticity of the central vestibular system
Authors
Issue Date2012
PublisherHKSN & BPHK.
Citation
The 2012 Hong Kong-Taiwan Physiology Symposium and Joint Scientific Meeting of Hong Kong Society of Neurosciences (HKSN) and The Biophysical Society of Hong Kong (BSHK), Hong Kong, 14-15 June 2012. In Program Book, 2012, p. 73, abstract P58 How to Cite?
AbstractPerineuronal nets (PN), as detectable by Wisteria floribunda agglutinin (WFA) staining, are extracellular matrix molecules surrounding GABAergic neurons. We hypothesize that PN regulate developmental plasticity of central vestibular circuitry containing GABAergic neurons. To address this, we looked for changes in PN during postnatal development of the central vestibular system. WFA-stained PN in the vestibular nucleus (VN) changed from diffuse organization in neonates to consolidated network in adults. Previous studies suggested that PN formation is activity-dependent. Therefore, the effect of vestibular deprivation on PN development in the VN was also investigated. Following bilateral labyrinthectomy (BL) at P3, the number of VN neurons with PN at adult stage was less than in normal controls. However, following BL at P7 or later, the number of PN-bound VN neurons were similar to normal controls. Our findings indicate that the first postnatal week is a critical period during which inputs from the peripheral afferents provide the necessary trigger for PN formation. The relationship between PN formation and maturation of vestibular functions was further studied with a behavioral test for negative geotaxis (a vestibular reflex). Normal rats acquired the mature response at P9, the time when PN consolidation was first observed. However, the acquisition was delayed to P13 in rats pretreated with chondroitinase ABC injection into the VN at P6 to prevent PN formation. Therefore, PN consolidation in the VN is critical to timely acquisition of the vestibular reflex. Taken together, our results show that PN undergo activity-dependent reorganization that corresponds to the maturation of vestibular behavior, indicating that PN play important roles in plasticity of the developing central vestibular system.
DescriptionPoster Presentation: P58
Persistent Identifierhttp://hdl.handle.net/10722/165080

 

DC FieldValueLanguage
dc.contributor.authorMa, CWen_US
dc.contributor.authorLai, CHen_US
dc.contributor.authorChan, YSen_US
dc.contributor.authorShum, DKYen_US
dc.date.accessioned2012-09-20T08:14:39Z-
dc.date.available2012-09-20T08:14:39Z-
dc.date.issued2012en_US
dc.identifier.citationThe 2012 Hong Kong-Taiwan Physiology Symposium and Joint Scientific Meeting of Hong Kong Society of Neurosciences (HKSN) and The Biophysical Society of Hong Kong (BSHK), Hong Kong, 14-15 June 2012. In Program Book, 2012, p. 73, abstract P58en_US
dc.identifier.urihttp://hdl.handle.net/10722/165080-
dc.descriptionPoster Presentation: P58-
dc.description.abstractPerineuronal nets (PN), as detectable by Wisteria floribunda agglutinin (WFA) staining, are extracellular matrix molecules surrounding GABAergic neurons. We hypothesize that PN regulate developmental plasticity of central vestibular circuitry containing GABAergic neurons. To address this, we looked for changes in PN during postnatal development of the central vestibular system. WFA-stained PN in the vestibular nucleus (VN) changed from diffuse organization in neonates to consolidated network in adults. Previous studies suggested that PN formation is activity-dependent. Therefore, the effect of vestibular deprivation on PN development in the VN was also investigated. Following bilateral labyrinthectomy (BL) at P3, the number of VN neurons with PN at adult stage was less than in normal controls. However, following BL at P7 or later, the number of PN-bound VN neurons were similar to normal controls. Our findings indicate that the first postnatal week is a critical period during which inputs from the peripheral afferents provide the necessary trigger for PN formation. The relationship between PN formation and maturation of vestibular functions was further studied with a behavioral test for negative geotaxis (a vestibular reflex). Normal rats acquired the mature response at P9, the time when PN consolidation was first observed. However, the acquisition was delayed to P13 in rats pretreated with chondroitinase ABC injection into the VN at P6 to prevent PN formation. Therefore, PN consolidation in the VN is critical to timely acquisition of the vestibular reflex. Taken together, our results show that PN undergo activity-dependent reorganization that corresponds to the maturation of vestibular behavior, indicating that PN play important roles in plasticity of the developing central vestibular system.-
dc.languageengen_US
dc.publisherHKSN & BPHK.-
dc.relation.ispartofHong Kong-Taiwan Physiology Symposium & HKSN-BSHK 2012 Joint Scientific Meetingen_US
dc.titleRoles of perineuronal matrix in developmental plasticity of the central vestibular systemen_US
dc.typeConference_Paperen_US
dc.identifier.emailMa, CW: cwma2010@hku.hken_US
dc.identifier.emailLai, CH: chlaib@hku.hken_US
dc.identifier.emailChan, YS: yschan@hku.hken_US
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_US
dc.identifier.authorityLai, CH=rp00396en_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.identifier.authorityShum, DKY=rp00321en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros200064en_US
dc.identifier.hkuros209411-
dc.identifier.spage73, abstract P58-
dc.identifier.epage73, abstract P58-
dc.publisher.placeHong Kong-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats