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Conference Paper: Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese

TitleAssociation of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese
Authors
KeywordsCardiovascular disease
Issue Date2010
PublisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3
Citation
The 14th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Hong Kong, 18 December 2010. In Journal of the Hong Kong College of Cardiology, 2010, v. 18 n. 2, p. 70, abstract no. P7 How to Cite?
Abstract
INTRODUCTION: We previously reported that the single nucleotide polymorphism (SNP) rs662799 (-1131T>C) in the apolipoprotein A5 gene (APOA5) was an important determinant of plasma triglycerides in both Hong Kong and Guangzhou Chinese. We, therefore, investigated the association of SNPs in APOA5 with the metabolic syndrome (MetS) in the Hong Kong and Guangzhou Chinese. METHODS: MetS was defined according to the consensus criteria proposed jointly by several organizations in 2009. Five tagging SNPs were genotyped in 1330 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort with follow-up after a median interval of 6.4 years. 1952 subjects from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort were used to replicate the findings. RESULTS: The minor allele of rs662799 was significantly associated with higher odds for the MetS in Hong Kong subjects at both baseline (OR=1.47, P=0.00082) and follow-up (OR=1.30, P=0.010). A similar association was found in Guangzhou subjects (OR=1.27, P=0.0041). In a pooled sample of Hong Kong subjects at follow-up and Guangzhou subjects, this SNP was also associated with HDL and LDL cholesterol (P<0.001 and 0.010 respectively). All these associations disappeared after further adjusting for plasma triglycerides (P>0.05). In a meta-analysis of 6 studies, the combined OR (95% CI) was 1.38 (1.25-1.52) for the TC + CC genotype compared to the TT genotype (P<0.00001). CONCLUSION: The association of -1131T>C polymorphism in APOA5 with the MetS was mainly due to its strong effect on plasma triglycerides. Further studies are needed to assess the utility of this genetic marker in risk stratification.
Persistent Identifierhttp://hdl.handle.net/10722/165047
ISSN
2013 SCImago Journal Rankings: 0.104

 

DC FieldValueLanguage
dc.contributor.authorOng, KLen_US
dc.contributor.authorLiang, CQen_US
dc.contributor.authorLiu, Ben_US
dc.contributor.authorJin, YLen_US
dc.contributor.authorTso, AWKen_US
dc.contributor.authorTam, Sen_US
dc.contributor.authorWong, KSen_US
dc.contributor.authorTomlinson, Ben_US
dc.contributor.authorCheung, BMYen_US
dc.contributor.authorLin, JMen_US
dc.contributor.authorYue, XJen_US
dc.contributor.authorLam, KSLen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorThomas, GNen_US
dc.date.accessioned2012-09-20T08:14:07Z-
dc.date.available2012-09-20T08:14:07Z-
dc.date.issued2010en_US
dc.identifier.citationThe 14th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Hong Kong, 18 December 2010. In Journal of the Hong Kong College of Cardiology, 2010, v. 18 n. 2, p. 70, abstract no. P7en_US
dc.identifier.issn1027-7811-
dc.identifier.urihttp://hdl.handle.net/10722/165047-
dc.description.abstractINTRODUCTION: We previously reported that the single nucleotide polymorphism (SNP) rs662799 (-1131T>C) in the apolipoprotein A5 gene (APOA5) was an important determinant of plasma triglycerides in both Hong Kong and Guangzhou Chinese. We, therefore, investigated the association of SNPs in APOA5 with the metabolic syndrome (MetS) in the Hong Kong and Guangzhou Chinese. METHODS: MetS was defined according to the consensus criteria proposed jointly by several organizations in 2009. Five tagging SNPs were genotyped in 1330 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort with follow-up after a median interval of 6.4 years. 1952 subjects from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort were used to replicate the findings. RESULTS: The minor allele of rs662799 was significantly associated with higher odds for the MetS in Hong Kong subjects at both baseline (OR=1.47, P=0.00082) and follow-up (OR=1.30, P=0.010). A similar association was found in Guangzhou subjects (OR=1.27, P=0.0041). In a pooled sample of Hong Kong subjects at follow-up and Guangzhou subjects, this SNP was also associated with HDL and LDL cholesterol (P<0.001 and 0.010 respectively). All these associations disappeared after further adjusting for plasma triglycerides (P>0.05). In a meta-analysis of 6 studies, the combined OR (95% CI) was 1.38 (1.25-1.52) for the TC + CC genotype compared to the TT genotype (P<0.00001). CONCLUSION: The association of -1131T>C polymorphism in APOA5 with the MetS was mainly due to its strong effect on plasma triglycerides. Further studies are needed to assess the utility of this genetic marker in risk stratification.-
dc.languageengen_US
dc.publisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3-
dc.relation.ispartofJournal of the Hong Kong College of Cardiologyen_US
dc.subjectCardiovascular disease-
dc.titleAssociation of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chineseen_US
dc.typeConference_Paperen_US
dc.identifier.emailOng, KL: okl2000@hku.hken_US
dc.identifier.emailTso, AWK: awktso@hku.hken_US
dc.identifier.emailTam, S: stam@hkucc.hku.hken_US
dc.identifier.emailCheung, BMY: mycheung@hku.hken_US
dc.identifier.emailLam, KSL: ksllam@hku.hken_US
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_US
dc.identifier.emailThomas, GN: neilt@hkucc.hku.hk-
dc.identifier.authorityTso, AWK=rp00535en_US
dc.identifier.authorityCheung, BMY=rp01321en_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros208556en_US
dc.identifier.volume18en_US
dc.identifier.issue2en_US
dc.identifier.spage70en_US
dc.identifier.epage70en_US
dc.publisher.placeHong Kong-
dc.description.otherThe 14th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Hong Kong, 18 December 2010. In Journal of the Hong Kong College of Cardiology, 2010, v. 18 n. 2, p. 70, abstract no. P7-

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