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Conference Paper: Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese
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TitleAssociation of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese
 
AuthorsOng, KL
Liang, CQ
Liu, B
Jin, YL
Tso, AWK
Tam, S
Wong, KS
Tomlinson, B
Cheung, BMY
Lin, JM
Yue, XJ
Lam, KSL
Lam, TH
Thomas, GN
 
KeywordsCardiovascular disease
 
Issue Date2010
 
PublisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3
 
CitationThe 14th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Hong Kong, 18 December 2010. In Journal of the Hong Kong College of Cardiology, 2010, v. 18 n. 2, p. 70, abstract no. P7 [How to Cite?]
 
AbstractINTRODUCTION: We previously reported that the single nucleotide polymorphism (SNP) rs662799 (-1131T>C) in the apolipoprotein A5 gene (APOA5) was an important determinant of plasma triglycerides in both Hong Kong and Guangzhou Chinese. We, therefore, investigated the association of SNPs in APOA5 with the metabolic syndrome (MetS) in the Hong Kong and Guangzhou Chinese. METHODS: MetS was defined according to the consensus criteria proposed jointly by several organizations in 2009. Five tagging SNPs were genotyped in 1330 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort with follow-up after a median interval of 6.4 years. 1952 subjects from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort were used to replicate the findings. RESULTS: The minor allele of rs662799 was significantly associated with higher odds for the MetS in Hong Kong subjects at both baseline (OR=1.47, P=0.00082) and follow-up (OR=1.30, P=0.010). A similar association was found in Guangzhou subjects (OR=1.27, P=0.0041). In a pooled sample of Hong Kong subjects at follow-up and Guangzhou subjects, this SNP was also associated with HDL and LDL cholesterol (P<0.001 and 0.010 respectively). All these associations disappeared after further adjusting for plasma triglycerides (P>0.05). In a meta-analysis of 6 studies, the combined OR (95% CI) was 1.38 (1.25-1.52) for the TC + CC genotype compared to the TT genotype (P<0.00001). CONCLUSION: The association of -1131T>C polymorphism in APOA5 with the MetS was mainly due to its strong effect on plasma triglycerides. Further studies are needed to assess the utility of this genetic marker in risk stratification.
 
ISSN1027-7811
2013 SCImago Journal Rankings: 0.104
 
DC FieldValue
dc.contributor.authorOng, KL
 
dc.contributor.authorLiang, CQ
 
dc.contributor.authorLiu, B
 
dc.contributor.authorJin, YL
 
dc.contributor.authorTso, AWK
 
dc.contributor.authorTam, S
 
dc.contributor.authorWong, KS
 
dc.contributor.authorTomlinson, B
 
dc.contributor.authorCheung, BMY
 
dc.contributor.authorLin, JM
 
dc.contributor.authorYue, XJ
 
dc.contributor.authorLam, KSL
 
dc.contributor.authorLam, TH
 
dc.contributor.authorThomas, GN
 
dc.date.accessioned2012-09-20T08:14:07Z
 
dc.date.available2012-09-20T08:14:07Z
 
dc.date.issued2010
 
dc.description.abstractINTRODUCTION: We previously reported that the single nucleotide polymorphism (SNP) rs662799 (-1131T>C) in the apolipoprotein A5 gene (APOA5) was an important determinant of plasma triglycerides in both Hong Kong and Guangzhou Chinese. We, therefore, investigated the association of SNPs in APOA5 with the metabolic syndrome (MetS) in the Hong Kong and Guangzhou Chinese. METHODS: MetS was defined according to the consensus criteria proposed jointly by several organizations in 2009. Five tagging SNPs were genotyped in 1330 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort with follow-up after a median interval of 6.4 years. 1952 subjects from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort were used to replicate the findings. RESULTS: The minor allele of rs662799 was significantly associated with higher odds for the MetS in Hong Kong subjects at both baseline (OR=1.47, P=0.00082) and follow-up (OR=1.30, P=0.010). A similar association was found in Guangzhou subjects (OR=1.27, P=0.0041). In a pooled sample of Hong Kong subjects at follow-up and Guangzhou subjects, this SNP was also associated with HDL and LDL cholesterol (P<0.001 and 0.010 respectively). All these associations disappeared after further adjusting for plasma triglycerides (P>0.05). In a meta-analysis of 6 studies, the combined OR (95% CI) was 1.38 (1.25-1.52) for the TC + CC genotype compared to the TT genotype (P<0.00001). CONCLUSION: The association of -1131T>C polymorphism in APOA5 with the MetS was mainly due to its strong effect on plasma triglycerides. Further studies are needed to assess the utility of this genetic marker in risk stratification.
 
dc.description.naturelink_to_OA_fulltext
 
dc.description.otherThe 14th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Hong Kong, 18 December 2010. In Journal of the Hong Kong College of Cardiology, 2010, v. 18 n. 2, p. 70, abstract no. P7
 
dc.identifier.citationThe 14th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Hong Kong, 18 December 2010. In Journal of the Hong Kong College of Cardiology, 2010, v. 18 n. 2, p. 70, abstract no. P7 [How to Cite?]
 
dc.identifier.epage70
 
dc.identifier.hkuros208556
 
dc.identifier.issn1027-7811
2013 SCImago Journal Rankings: 0.104
 
dc.identifier.issue2
 
dc.identifier.spage70
 
dc.identifier.urihttp://hdl.handle.net/10722/165047
 
dc.identifier.volume18
 
dc.languageeng
 
dc.publisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3
 
dc.publisher.placeHong Kong
 
dc.relation.ispartofJournal of the Hong Kong College of Cardiology
 
dc.subjectCardiovascular disease
 
dc.titleAssociation of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese
 
dc.typeConference_Paper
 
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<item><contributor.author>Ong, KL</contributor.author>
<contributor.author>Liang, CQ</contributor.author>
<contributor.author>Liu, B</contributor.author>
<contributor.author>Jin, YL</contributor.author>
<contributor.author>Tso, AWK</contributor.author>
<contributor.author>Tam, S</contributor.author>
<contributor.author>Wong, KS</contributor.author>
<contributor.author>Tomlinson, B</contributor.author>
<contributor.author>Cheung, BMY</contributor.author>
<contributor.author>Lin, JM</contributor.author>
<contributor.author>Yue, XJ</contributor.author>
<contributor.author>Lam, KSL</contributor.author>
<contributor.author>Lam, TH</contributor.author>
<contributor.author>Thomas, GN</contributor.author>
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<description.abstract>INTRODUCTION: We previously reported that the single nucleotide polymorphism (SNP) rs662799 (-1131T&gt;C) in the apolipoprotein A5 gene (APOA5) was an important determinant of plasma triglycerides in both Hong Kong and Guangzhou Chinese. We, therefore, investigated the association of SNPs in APOA5 with the metabolic syndrome (MetS) in the Hong Kong and Guangzhou Chinese. METHODS: MetS was defined according to the consensus criteria proposed jointly by several organizations in 2009. Five tagging SNPs were genotyped in 1330 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort with follow-up after a median interval of 6.4 years. 1952 subjects from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort were used to replicate the findings. RESULTS: The minor allele of rs662799 was significantly associated with higher odds for the MetS in Hong Kong subjects at both baseline (OR=1.47, P=0.00082) and follow-up (OR=1.30, P=0.010). A similar association was found in Guangzhou subjects (OR=1.27, P=0.0041). In a pooled sample of Hong Kong subjects at follow-up and Guangzhou subjects, this SNP was also associated with HDL and LDL cholesterol (P&lt;0.001 and 0.010 respectively). All these associations disappeared after further adjusting for plasma triglycerides (P&gt;0.05). In a meta-analysis of 6 studies, the combined OR (95% CI) was 1.38 (1.25-1.52) for the TC + CC genotype compared to the TT genotype (P&lt;0.00001). CONCLUSION: The association of -1131T&gt;C polymorphism in APOA5 with the MetS was mainly due to its strong effect on plasma triglycerides. Further studies are needed to assess the utility of this genetic marker in risk stratification.</description.abstract>
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