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Article: Regulatory dendritic cells program B cells to differentiate into CD19hiFcγIIbhi regulatory B cells through IFN-β and CD40L
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TitleRegulatory dendritic cells program B cells to differentiate into CD19hiFcγIIbhi regulatory B cells through IFN-β and CD40L
 
AuthorsQian, L1 4
Qian, C4
Chen, Y4
Bai, Y4
Bao, Y4
Lu, L2
Cao, X4 3
 
Issue Date2012
 
PublisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/
 
CitationBlood, 2012, v. 120 n. 3, p. 581-591 [How to Cite?]
DOI: http://dx.doi.org/10.1182/blood-2011-08-377242
 
AbstractRegulatory dendritic cells (DCs) play important roles in the induction of peripheral tolerance and control of adaptive immune response. Our previous studies demonstrate that splenic stroma can drive mature DCs to proliferate and further differentiate into a unique subset of CD11b(hi)Ia(low) regulatory DCs, which could inhibit T-cell response, program generation of immunosuppressive memory CD4 T cells. However, the effect of regulatory DCs on B-cell function remains unclear. Here, we report that regulatory DCs can induce splenic B cells to differentiate into a distinct subtype of IL-10-producing regulatory B cells with unique phenotype CD19(hi)FcgammaIIb(hi). CD19(hi)FcgammaIIb(hi) B cells inhibit CD4 T-cell response via IL-10. CD19(hi)FcgammaIIb(hi) B cells have enhanced phagocytic capacity compared with conventional CD19(+) B cells, and FcgammaRIIb mediates the uptake of immune complex by CD19(hi)FcgammaIIb(hi) B cells. We found that regulatory DC-derived IFN-beta and CD40 ligand are responsible for the differentiation of CD19(hi)FcgammaIIb(hi) B cells. Furthermore, an in vivo counterpart of CD19(hi)FcgammaIIb(hi) B cells in the spleen and lymph nodes with similar phenotype and regulatory function has been identified. Our results demonstrate a new manner for regulatory DCs to down-regulate immune response by, at least partially, programming B cells into regulatory B cells.
 
ISSN0006-4971
2013 Impact Factor: 9.775
 
DOIhttp://dx.doi.org/10.1182/blood-2011-08-377242
 
ISI Accession Number IDWOS:000307440100015
 
DC FieldValue
dc.contributor.authorQian, L
 
dc.contributor.authorQian, C
 
dc.contributor.authorChen, Y
 
dc.contributor.authorBai, Y
 
dc.contributor.authorBao, Y
 
dc.contributor.authorLu, L
 
dc.contributor.authorCao, X
 
dc.date.accessioned2012-09-20T08:10:49Z
 
dc.date.available2012-09-20T08:10:49Z
 
dc.date.issued2012
 
dc.description.abstractRegulatory dendritic cells (DCs) play important roles in the induction of peripheral tolerance and control of adaptive immune response. Our previous studies demonstrate that splenic stroma can drive mature DCs to proliferate and further differentiate into a unique subset of CD11b(hi)Ia(low) regulatory DCs, which could inhibit T-cell response, program generation of immunosuppressive memory CD4 T cells. However, the effect of regulatory DCs on B-cell function remains unclear. Here, we report that regulatory DCs can induce splenic B cells to differentiate into a distinct subtype of IL-10-producing regulatory B cells with unique phenotype CD19(hi)FcgammaIIb(hi). CD19(hi)FcgammaIIb(hi) B cells inhibit CD4 T-cell response via IL-10. CD19(hi)FcgammaIIb(hi) B cells have enhanced phagocytic capacity compared with conventional CD19(+) B cells, and FcgammaRIIb mediates the uptake of immune complex by CD19(hi)FcgammaIIb(hi) B cells. We found that regulatory DC-derived IFN-beta and CD40 ligand are responsible for the differentiation of CD19(hi)FcgammaIIb(hi) B cells. Furthermore, an in vivo counterpart of CD19(hi)FcgammaIIb(hi) B cells in the spleen and lymph nodes with similar phenotype and regulatory function has been identified. Our results demonstrate a new manner for regulatory DCs to down-regulate immune response by, at least partially, programming B cells into regulatory B cells.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationBlood, 2012, v. 120 n. 3, p. 581-591 [How to Cite?]
DOI: http://dx.doi.org/10.1182/blood-2011-08-377242
 
dc.identifier.doihttp://dx.doi.org/10.1182/blood-2011-08-377242
 
dc.identifier.epage591
 
dc.identifier.hkuros208182
 
dc.identifier.isiWOS:000307440100015
 
dc.identifier.issn0006-4971
2013 Impact Factor: 9.775
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid22692512
 
dc.identifier.scopuseid_2-s2.0-84864126038
 
dc.identifier.spage581
 
dc.identifier.urihttp://hdl.handle.net/10722/164844
 
dc.identifier.volume120
 
dc.languageeng
 
dc.publisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofBlood
 
dc.rightsThis research was originally published in The Hematologist: ASH News and Reports. Author(s). Title. The Hematologist: ASH News and Reports. Year;Vol,Issue:pp-pp. © the American Society of Hematology.
 
dc.subject.meshAntigens, CD19 - immunology - metabolism
 
dc.subject.meshB-Lymphocytes - cytology - immunology - metabolism
 
dc.subject.meshCD40 Ligand - immunology - metabolism
 
dc.subject.meshDendritic Cells - cytology - immunology - metabolism
 
dc.subject.meshInterferon-beta - immunology - metabolism
 
dc.titleRegulatory dendritic cells program B cells to differentiate into CD19hiFcγIIbhi regulatory B cells through IFN-β and CD40L
 
dc.typeArticle
 
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<contributor.author>Qian, C</contributor.author>
<contributor.author>Chen, Y</contributor.author>
<contributor.author>Bai, Y</contributor.author>
<contributor.author>Bao, Y</contributor.author>
<contributor.author>Lu, L</contributor.author>
<contributor.author>Cao, X</contributor.author>
<date.accessioned>2012-09-20T08:10:49Z</date.accessioned>
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<description.abstract>Regulatory dendritic cells (DCs) play important roles in the induction of peripheral tolerance and control of adaptive immune response. Our previous studies demonstrate that splenic stroma can drive mature DCs to proliferate and further differentiate into a unique subset of CD11b(hi)Ia(low) regulatory DCs, which could inhibit T-cell response, program generation of immunosuppressive memory CD4 T cells. However, the effect of regulatory DCs on B-cell function remains unclear. Here, we report that regulatory DCs can induce splenic B cells to differentiate into a distinct subtype of IL-10-producing regulatory B cells with unique phenotype CD19(hi)FcgammaIIb(hi). CD19(hi)FcgammaIIb(hi) B cells inhibit CD4 T-cell response via IL-10. CD19(hi)FcgammaIIb(hi) B cells have enhanced phagocytic capacity compared with conventional CD19(+) B cells, and FcgammaRIIb mediates the uptake of immune complex by CD19(hi)FcgammaIIb(hi) B cells. We found that regulatory DC-derived IFN-beta and CD40 ligand are responsible for the differentiation of CD19(hi)FcgammaIIb(hi) B cells. Furthermore, an in vivo counterpart of CD19(hi)FcgammaIIb(hi) B cells in the spleen and lymph nodes with similar phenotype and regulatory function has been identified. Our results demonstrate a new manner for regulatory DCs to down-regulate immune response by, at least partially, programming B cells into regulatory B cells.</description.abstract>
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<subject.mesh>Antigens, CD19 - immunology - metabolism</subject.mesh>
<subject.mesh>B-Lymphocytes - cytology - immunology - metabolism</subject.mesh>
<subject.mesh>CD40 Ligand - immunology - metabolism</subject.mesh>
<subject.mesh>Dendritic Cells - cytology - immunology - metabolism</subject.mesh>
<subject.mesh>Interferon-beta - immunology - metabolism</subject.mesh>
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Author Affiliations
  1. Yangzhou University
  2. The University of Hong Kong
  3. Chinese Academy of Medical Sciences
  4. Second Military Medical University