File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Transmural strain and rotation gradient in survivors of childhood cancers

TitleTransmural strain and rotation gradient in survivors of childhood cancers
Authors
KeywordsChildhood cancer survivors
Anthracycline
Speckle tracking echocardiography
Myocardial strain gradient
Issue Date2013
PublisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
Citation
European Heart Journal, 2013, v. 14 n. 2, p. 175-182 How to Cite?
AbstractAIMS: Subendocardial layer of the ventricle has been shown to be sensitive to anthracycline damage. This study tested the hypothesis that anthracycline therapy for childhood malignancies has differential impact on deformation and rotation of left ventricular (LV) subendocardial and subepicardial layers and hence transmural myocardial strain and rotation gradients. METHODS AND RESULTS: Thirty-two anthracycline-treated survivors of childhood malignancies aged 19.3 +/- 5.4 years and 28 controls were studied. Apical four-chamber and parasternal LV short-axis acquisitions at base, papillary muscle level, and apex were analysed for layer-specific myocardial strain and apical and basal rotation and rotational velocities using two-dimensional speckle tracking echocardiography. Transmural strain and rotation gradients were calculated as differences between peak systolic strain and rotation between the inner and outer layers, respectively. Compared with controls, patients had significantly lower transmural circumferential, but not radial or longitudinal, strain gradients (P< 0.05), accounted by the reduced subendocardial circumferential strain, at all three ventricular levels (all P< 0.05). No significant difference in basal transmural rotation gradient was found between patients and controls (P= 0.32). On the other hand, apical rotation, systolic twisting velocity, and diastolic untwisting velocity were reduced preferentially at the subendocardial layer in patients (all P< 0.05), hence accounting for their significantly reduced transmural rotation gradient compared with controls (P< 0.001). The LV ejection fraction correlated inversely with apical transmural circumferential strain gradient (r= -0.39, P= 0.002) and rotation gradient (r= 0.33, P= 0.01). CONCLUSION: Preferential impairment of subendocardial circumferential deformation and apical rotation with consequential reduction of transmural circumferential strain and rotation gradients occurs in anthracycline-treated survivors of childhood cancers.
Persistent Identifierhttp://hdl.handle.net/10722/164469
ISSN
2019 Impact Factor: 22.673
2015 SCImago Journal Rankings: 6.997
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYu, W-
dc.contributor.authorLi, SN-
dc.contributor.authorChan, GCF-
dc.contributor.authorHa, SY-
dc.contributor.authorWong, SJ-
dc.contributor.authorCheung, YF-
dc.date.accessioned2012-09-20T08:00:00Z-
dc.date.available2012-09-20T08:00:00Z-
dc.date.issued2013-
dc.identifier.citationEuropean Heart Journal, 2013, v. 14 n. 2, p. 175-182-
dc.identifier.issn0195-668X-
dc.identifier.urihttp://hdl.handle.net/10722/164469-
dc.description.abstractAIMS: Subendocardial layer of the ventricle has been shown to be sensitive to anthracycline damage. This study tested the hypothesis that anthracycline therapy for childhood malignancies has differential impact on deformation and rotation of left ventricular (LV) subendocardial and subepicardial layers and hence transmural myocardial strain and rotation gradients. METHODS AND RESULTS: Thirty-two anthracycline-treated survivors of childhood malignancies aged 19.3 +/- 5.4 years and 28 controls were studied. Apical four-chamber and parasternal LV short-axis acquisitions at base, papillary muscle level, and apex were analysed for layer-specific myocardial strain and apical and basal rotation and rotational velocities using two-dimensional speckle tracking echocardiography. Transmural strain and rotation gradients were calculated as differences between peak systolic strain and rotation between the inner and outer layers, respectively. Compared with controls, patients had significantly lower transmural circumferential, but not radial or longitudinal, strain gradients (P< 0.05), accounted by the reduced subendocardial circumferential strain, at all three ventricular levels (all P< 0.05). No significant difference in basal transmural rotation gradient was found between patients and controls (P= 0.32). On the other hand, apical rotation, systolic twisting velocity, and diastolic untwisting velocity were reduced preferentially at the subendocardial layer in patients (all P< 0.05), hence accounting for their significantly reduced transmural rotation gradient compared with controls (P< 0.001). The LV ejection fraction correlated inversely with apical transmural circumferential strain gradient (r= -0.39, P= 0.002) and rotation gradient (r= 0.33, P= 0.01). CONCLUSION: Preferential impairment of subendocardial circumferential deformation and apical rotation with consequential reduction of transmural circumferential strain and rotation gradients occurs in anthracycline-treated survivors of childhood cancers.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/-
dc.relation.ispartofEuropean Heart Journal-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here]. -
dc.subjectChildhood cancer survivors-
dc.subjectAnthracycline-
dc.subjectSpeckle tracking echocardiography-
dc.subjectMyocardial strain gradient-
dc.titleTransmural strain and rotation gradient in survivors of childhood cancers-
dc.typeArticle-
dc.identifier.emailLi, SN: lishuna@hku.hk-
dc.identifier.emailChan, GCF: gcfchan@hku.hk-
dc.identifier.emailHa, SY: syha@hku.hk-
dc.identifier.emailWong, SJ: sjwong@hku.hk-
dc.identifier.emailCheung, YF: xfcheung@hku.hk-
dc.identifier.authorityChan, GCF=rp00431-
dc.identifier.authorityCheung, YF=rp00382-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/ehjci/jes143-
dc.identifier.pmid22802431-
dc.identifier.scopuseid_2-s2.0-84872482210-
dc.identifier.hkuros210631-
dc.identifier.volume14-
dc.identifier.issue2-
dc.identifier.spage175-
dc.identifier.epage182-
dc.identifier.isiWOS:000313618300017-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats