File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Transmural strain and rotation gradient in survivors of childhood cancers
  • Basic View
  • Metadata View
  • XML View
TitleTransmural strain and rotation gradient in survivors of childhood cancers
 
AuthorsYu, W1
Li, SN1
Chan, GCF1
Ha, SY1
Wong, SJ1
Cheung, YF1
 
KeywordsChildhood cancer survivors
Anthracycline
Speckle tracking echocardiography
Myocardial strain gradient
 
Issue Date2012
 
PublisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
 
CitationEuropean Heart Journal, 2012 [Epub ahead of print] [How to Cite?]
DOI: http://dx.doi.org/10.1093/ehjci/jes143
 
AbstractAIMS: Subendocardial layer of the ventricle has been shown to be sensitive to anthracycline damage. This study tested the hypothesis that anthracycline therapy for childhood malignancies has differential impact on deformation and rotation of left ventricular (LV) subendocardial and subepicardial layers and hence transmural myocardial strain and rotation gradients. METHODS AND RESULTS: Thirty-two anthracycline-treated survivors of childhood malignancies aged 19.3 +/- 5.4 years and 28 controls were studied. Apical four-chamber and parasternal LV short-axis acquisitions at base, papillary muscle level, and apex were analysed for layer-specific myocardial strain and apical and basal rotation and rotational velocities using two-dimensional speckle tracking echocardiography. Transmural strain and rotation gradients were calculated as differences between peak systolic strain and rotation between the inner and outer layers, respectively. Compared with controls, patients had significantly lower transmural circumferential, but not radial or longitudinal, strain gradients (P< 0.05), accounted by the reduced subendocardial circumferential strain, at all three ventricular levels (all P< 0.05). No significant difference in basal transmural rotation gradient was found between patients and controls (P= 0.32). On the other hand, apical rotation, systolic twisting velocity, and diastolic untwisting velocity were reduced preferentially at the subendocardial layer in patients (all P< 0.05), hence accounting for their significantly reduced transmural rotation gradient compared with controls (P< 0.001). The LV ejection fraction correlated inversely with apical transmural circumferential strain gradient (r= -0.39, P= 0.002) and rotation gradient (r= 0.33, P= 0.01). CONCLUSION: Preferential impairment of subendocardial circumferential deformation and apical rotation with consequential reduction of transmural circumferential strain and rotation gradients occurs in anthracycline-treated survivors of childhood cancers.
 
ISSN0195-668X
2013 Impact Factor: 14.723
 
DOIhttp://dx.doi.org/10.1093/ehjci/jes143
 
ISI Accession Number IDWOS:000313618300017
 
DC FieldValue
dc.contributor.authorYu, W
 
dc.contributor.authorLi, SN
 
dc.contributor.authorChan, GCF
 
dc.contributor.authorHa, SY
 
dc.contributor.authorWong, SJ
 
dc.contributor.authorCheung, YF
 
dc.date.accessioned2012-09-20T08:00:00Z
 
dc.date.available2012-09-20T08:00:00Z
 
dc.date.issued2012
 
dc.description.abstractAIMS: Subendocardial layer of the ventricle has been shown to be sensitive to anthracycline damage. This study tested the hypothesis that anthracycline therapy for childhood malignancies has differential impact on deformation and rotation of left ventricular (LV) subendocardial and subepicardial layers and hence transmural myocardial strain and rotation gradients. METHODS AND RESULTS: Thirty-two anthracycline-treated survivors of childhood malignancies aged 19.3 +/- 5.4 years and 28 controls were studied. Apical four-chamber and parasternal LV short-axis acquisitions at base, papillary muscle level, and apex were analysed for layer-specific myocardial strain and apical and basal rotation and rotational velocities using two-dimensional speckle tracking echocardiography. Transmural strain and rotation gradients were calculated as differences between peak systolic strain and rotation between the inner and outer layers, respectively. Compared with controls, patients had significantly lower transmural circumferential, but not radial or longitudinal, strain gradients (P< 0.05), accounted by the reduced subendocardial circumferential strain, at all three ventricular levels (all P< 0.05). No significant difference in basal transmural rotation gradient was found between patients and controls (P= 0.32). On the other hand, apical rotation, systolic twisting velocity, and diastolic untwisting velocity were reduced preferentially at the subendocardial layer in patients (all P< 0.05), hence accounting for their significantly reduced transmural rotation gradient compared with controls (P< 0.001). The LV ejection fraction correlated inversely with apical transmural circumferential strain gradient (r= -0.39, P= 0.002) and rotation gradient (r= 0.33, P= 0.01). CONCLUSION: Preferential impairment of subendocardial circumferential deformation and apical rotation with consequential reduction of transmural circumferential strain and rotation gradients occurs in anthracycline-treated survivors of childhood cancers.
 
dc.identifier.citationEuropean Heart Journal, 2012 [Epub ahead of print] [How to Cite?]
DOI: http://dx.doi.org/10.1093/ehjci/jes143
 
dc.identifier.doihttp://dx.doi.org/10.1093/ehjci/jes143
 
dc.identifier.hkuros210631
 
dc.identifier.isiWOS:000313618300017
 
dc.identifier.issn0195-668X
2013 Impact Factor: 14.723
 
dc.identifier.pmid22802431
 
dc.identifier.scopuseid_2-s2.0-84872482210
 
dc.identifier.urihttp://hdl.handle.net/10722/164469
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofEuropean Heart Journal
 
dc.subjectChildhood cancer survivors
 
dc.subjectAnthracycline
 
dc.subjectSpeckle tracking echocardiography
 
dc.subjectMyocardial strain gradient
 
dc.titleTransmural strain and rotation gradient in survivors of childhood cancers
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Yu, W</contributor.author>
<contributor.author>Li, SN</contributor.author>
<contributor.author>Chan, GCF</contributor.author>
<contributor.author>Ha, SY</contributor.author>
<contributor.author>Wong, SJ</contributor.author>
<contributor.author>Cheung, YF</contributor.author>
<date.accessioned>2012-09-20T08:00:00Z</date.accessioned>
<date.available>2012-09-20T08:00:00Z</date.available>
<date.issued>2012</date.issued>
<identifier.citation>European Heart Journal, 2012 [Epub ahead of print]</identifier.citation>
<identifier.issn>0195-668X</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/164469</identifier.uri>
<description.abstract>AIMS: Subendocardial layer of the ventricle has been shown to be sensitive to anthracycline damage. This study tested the hypothesis that anthracycline therapy for childhood malignancies has differential impact on deformation and rotation of left ventricular (LV) subendocardial and subepicardial layers and hence transmural myocardial strain and rotation gradients. METHODS AND RESULTS: Thirty-two anthracycline-treated survivors of childhood malignancies aged 19.3 +/- 5.4 years and 28 controls were studied. Apical four-chamber and parasternal LV short-axis acquisitions at base, papillary muscle level, and apex were analysed for layer-specific myocardial strain and apical and basal rotation and rotational velocities using two-dimensional speckle tracking echocardiography. Transmural strain and rotation gradients were calculated as differences between peak systolic strain and rotation between the inner and outer layers, respectively. Compared with controls, patients had significantly lower transmural circumferential, but not radial or longitudinal, strain gradients (P&lt; 0.05), accounted by the reduced subendocardial circumferential strain, at all three ventricular levels (all P&lt; 0.05). No significant difference in basal transmural rotation gradient was found between patients and controls (P= 0.32). On the other hand, apical rotation, systolic twisting velocity, and diastolic untwisting velocity were reduced preferentially at the subendocardial layer in patients (all P&lt; 0.05), hence accounting for their significantly reduced transmural rotation gradient compared with controls (P&lt; 0.001). The LV ejection fraction correlated inversely with apical transmural circumferential strain gradient (r= -0.39, P= 0.002) and rotation gradient (r= 0.33, P= 0.01). CONCLUSION: Preferential impairment of subendocardial circumferential deformation and apical rotation with consequential reduction of transmural circumferential strain and rotation gradients occurs in anthracycline-treated survivors of childhood cancers.</description.abstract>
<language>eng</language>
<publisher>Oxford University Press. The Journal&apos;s web site is located at http://eurheartj.oxfordjournals.org/</publisher>
<relation.ispartof>European Heart Journal</relation.ispartof>
<subject>Childhood cancer survivors</subject>
<subject>Anthracycline</subject>
<subject>Speckle tracking echocardiography</subject>
<subject>Myocardial strain gradient</subject>
<title>Transmural strain and rotation gradient in survivors of childhood cancers</title>
<type>Article</type>
<identifier.doi>10.1093/ehjci/jes143</identifier.doi>
<identifier.pmid>22802431</identifier.pmid>
<identifier.scopus>eid_2-s2.0-84872482210</identifier.scopus>
<identifier.hkuros>210631</identifier.hkuros>
<identifier.isi>WOS:000313618300017</identifier.isi>
<publisher.place>United Kingdom</publisher.place>
</item>
Author Affiliations
  1. The University of Hong Kong