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Article: High hepatitis B surface antigen levels predict insignificant fibrosis in hepatitis B e antigen positive chronic hepatitis B

TitleHigh hepatitis B surface antigen levels predict insignificant fibrosis in hepatitis B e antigen positive chronic hepatitis B
Authors
KeywordsAccuracy
Alanine aminotransferase blood level
Diagnostic test accuracy study
Disease severity
Hepatitis B
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2012, v. 7 n. 8, article no. e43087 How to Cite?
AbstractINTRODUCTION: There is no data on the relationship between hepatitis B surface antigen (HBsAg) levels and liver fibrosis in hepatitis B e antigen (HBeAg)-positive patients with chronic hepatitis B (CHB). METHODS: Serum HBsAg and HBV DNA levels in HBeAg-positive CHB patients with liver biopsies were analyzed. The upper limit of normal (ULN) of alanine aminotransferase (ALT) was 30 and 19 U/L for men and women respectively. Histologic assessment was based on Ishak fibrosis staging for fibrosis and Knodell histologic activity index (HAI) for necroinflammation. RESULTS: 140 patients (65% male, median age 32.7 years) were recruited. 56 (40%) had ALT 1, had significantly higher median HBsAg levels (50,320 and 7,820 IU/mL respectively, p<0.001). Among patients with ALT /= 25,000 IU/mL was independently associated with fibrosis score
Persistent Identifierhttp://hdl.handle.net/10722/164323
ISSN
2014 Impact Factor: 3.234
2014 SCImago Journal Rankings: 1.300
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSeto, WKen_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorFung, Jen_HK
dc.contributor.authorIp, PPCen_HK
dc.contributor.authorYuen, JCHen_HK
dc.contributor.authorHung, IFNen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorYuen, MFen_HK
dc.date.accessioned2012-09-20T07:57:58Z-
dc.date.available2012-09-20T07:57:58Z-
dc.date.issued2012en_HK
dc.identifier.citationPLoS One, 2012, v. 7 n. 8, article no. e43087en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/164323-
dc.description.abstractINTRODUCTION: There is no data on the relationship between hepatitis B surface antigen (HBsAg) levels and liver fibrosis in hepatitis B e antigen (HBeAg)-positive patients with chronic hepatitis B (CHB). METHODS: Serum HBsAg and HBV DNA levels in HBeAg-positive CHB patients with liver biopsies were analyzed. The upper limit of normal (ULN) of alanine aminotransferase (ALT) was 30 and 19 U/L for men and women respectively. Histologic assessment was based on Ishak fibrosis staging for fibrosis and Knodell histologic activity index (HAI) for necroinflammation. RESULTS: 140 patients (65% male, median age 32.7 years) were recruited. 56 (40%) had ALT </=2xULN. 72 (51.4%) and 42 (30%) had fibrosis score </= 1 and necroinflammation grading </= 4 respectively. Patients with fibrosis score </= 1, when compared to patients with fibrosis score >1, had significantly higher median HBsAg levels (50,320 and 7,820 IU/mL respectively, p<0.001). Among patients with ALT </=2xULN, serum HBsAg levels achieved an area under receiver operating characteristic curve of 0.869 in predicting fibrosis score </= 1. HBsAg levels did not accurately predict necroinflammation score. HBsAg >/= 25,000 IU/mL was independently associated with fibrosis score </= 1 (p=0.025, odds ratio 9.042).Using this cut-off HBsAg level in patients with ALT </=2xULN, positive and negative predictive values for predicting fibrosis score </= 1 were 92.7% and 60.0% respectively. HBV DNA levels had no association with liver histology. CONCLUSION: Among HBeAg-positive patients with ALT </=2xULN, high serum HBsAg levels can accurately predict fibrosis score </= 1, and could potentially influence decisions concerning treatment commencement and reduce the need for liver biopsy.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS Oneen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAccuracy-
dc.subjectAlanine aminotransferase blood level-
dc.subjectDiagnostic test accuracy study-
dc.subjectDisease severity-
dc.subjectHepatitis B-
dc.titleHigh hepatitis B surface antigen levels predict insignificant fibrosis in hepatitis B e antigen positive chronic hepatitis Ben_HK
dc.typeArticleen_HK
dc.identifier.emailSeto, WK: wkseto@gmail.comen_HK
dc.identifier.emailWong, DKH: danywong@hku.hken_HK
dc.identifier.emailFung, J: jfung@hkucc.hku.hken_HK
dc.identifier.emailIp, PPC: philipip@hkucc.hku.hken_HK
dc.identifier.emailYuen, JCH: jchyuen@hkucc.hku.hken_HK
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hk-
dc.identifier.emailLai, CL: hrmelcl@hku.hk-
dc.identifier.emailYuen, MF: mfyuen@hku.hk-
dc.identifier.authoritySeto, WK=rp01659en_HK
dc.identifier.authorityWong, DH=rp00492en_HK
dc.identifier.authorityFung, J=rp00518en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0043087en_HK
dc.identifier.pmid22916211-
dc.identifier.pmcidPMC3423440-
dc.identifier.scopuseid_2-s2.0-84865176357en_HK
dc.identifier.hkuros208878en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84865176357&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue8, article no. e43087en_HK
dc.identifier.isiWOS:000307733800046-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridHung, IN=55193217000en_HK
dc.identifier.scopusauthoridYuen, JH=7102620480en_HK
dc.identifier.scopusauthoridIp, PPC=54958906200en_HK
dc.identifier.scopusauthoridFung, J=23091109300en_HK
dc.identifier.scopusauthoridWong, DH=7401535819en_HK
dc.identifier.scopusauthoridSeto, WK=23390675900en_HK

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