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Conference Paper: Intrinsic cells: Mesothelial cells - Central players in regulating inflammation and resolution

TitleIntrinsic cells: Mesothelial cells - Central players in regulating inflammation and resolution
Authors
Issue Date2009
PublisherMultimed, Inc. The Journal's web site is located at http://pdiconnect.com
Citation
Peritoneal Dialysis International, 2009, v. 29 SUPPL. 2, p. S21-S27 How to Cite?
Abstract◆ Background: Preservation of the structural and functional integrity of the peritoneum is essential to maintain the dialytic efficacy of the peritoneal membrane. Although much improvement has been made to peritoneal dialysis (PD) fluids, they remain bioincompatible, and together with peritonitis, they continue to induce peritoneal inflammation and fibrosis. ◆ Method: This article reviews the putative factors that mediate mesothelial cell inflammation during PD, and the mechanisms by which mesothelial cells attempt to regulate and resolve peritoneal inflammation. ◆ Results: The mesothelium is the first line of defense to foreign particles and chemicals in the peritoneal cavity. Constant exposure of the mesothelium to the bioincompatible constituents of PD solutions results in denudation of the mesothelium and loss of the peritoneal cavity's protective layer. Detached mesothelial cells in PD solutions have the capacity to replenish the mesothelial layer through their ability to migrate and attach to areas of denudation. Mesothelial cells synthesize a plethora of growth factors, matrix proteins, and proteoglycans that aid in the reparative process and regulate the formation of chemotactic gradients that are essential for infiltration of leukocytes to sites of injury. ◆ Conclusions: Far from being bystanders in peritoneal function, mesothelial cells have been shown to play a dynamic role in peritoneal homeostasis and immunoregulation. Studies have highlighted the potential use of mesothelial cells in gene therapy and cell transplantation, both of which may provide novel therapeutic strategies for the preservation of the peritoneum during PD. Copyright © 2009 International Society for Peritoneal Dialysis.
Persistent Identifierhttp://hdl.handle.net/10722/163571
ISSN
2015 Impact Factor: 1.298
2015 SCImago Journal Rankings: 0.683
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYung, Sen_US
dc.contributor.authorChan, TMen_US
dc.date.accessioned2012-09-05T05:37:28Z-
dc.date.available2012-09-05T05:37:28Z-
dc.date.issued2009en_US
dc.identifier.citationPeritoneal Dialysis International, 2009, v. 29 SUPPL. 2, p. S21-S27en_US
dc.identifier.issn0896-8608en_US
dc.identifier.urihttp://hdl.handle.net/10722/163571-
dc.description.abstract◆ Background: Preservation of the structural and functional integrity of the peritoneum is essential to maintain the dialytic efficacy of the peritoneal membrane. Although much improvement has been made to peritoneal dialysis (PD) fluids, they remain bioincompatible, and together with peritonitis, they continue to induce peritoneal inflammation and fibrosis. ◆ Method: This article reviews the putative factors that mediate mesothelial cell inflammation during PD, and the mechanisms by which mesothelial cells attempt to regulate and resolve peritoneal inflammation. ◆ Results: The mesothelium is the first line of defense to foreign particles and chemicals in the peritoneal cavity. Constant exposure of the mesothelium to the bioincompatible constituents of PD solutions results in denudation of the mesothelium and loss of the peritoneal cavity's protective layer. Detached mesothelial cells in PD solutions have the capacity to replenish the mesothelial layer through their ability to migrate and attach to areas of denudation. Mesothelial cells synthesize a plethora of growth factors, matrix proteins, and proteoglycans that aid in the reparative process and regulate the formation of chemotactic gradients that are essential for infiltration of leukocytes to sites of injury. ◆ Conclusions: Far from being bystanders in peritoneal function, mesothelial cells have been shown to play a dynamic role in peritoneal homeostasis and immunoregulation. Studies have highlighted the potential use of mesothelial cells in gene therapy and cell transplantation, both of which may provide novel therapeutic strategies for the preservation of the peritoneum during PD. Copyright © 2009 International Society for Peritoneal Dialysis.en_US
dc.languageengen_US
dc.publisherMultimed, Inc. The Journal's web site is located at http://pdiconnect.comen_US
dc.relation.ispartofPeritoneal Dialysis Internationalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Differentiation - Drug Effectsen_US
dc.subject.meshDialysis Solutions - Adverse Effectsen_US
dc.subject.meshEpithelial Cells - Metabolism - Pathologyen_US
dc.subject.meshGlycosaminoglycans - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Failure, Chronic - Therapyen_US
dc.subject.meshPeritoneal Dialysis - Adverse Effectsen_US
dc.subject.meshPeritonitis - Etiology - Metabolism - Pathologyen_US
dc.subject.meshProteoglycans - Metabolismen_US
dc.subject.meshRecovery Of Functionen_US
dc.titleIntrinsic cells: Mesothelial cells - Central players in regulating inflammation and resolutionen_US
dc.typeConference_Paperen_US
dc.identifier.emailYung, S:ssyyung@hku.hken_US
dc.identifier.authorityYung, S=rp00455en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid19270220en_US
dc.identifier.scopuseid_2-s2.0-67449098531en_US
dc.identifier.hkuros157925-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67449098531&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume29en_US
dc.identifier.issueSUPPL. 2en_US
dc.identifier.spageS21en_US
dc.identifier.epageS27en_US
dc.identifier.isiWOS:000263937100003-
dc.publisher.placeCanadaen_US
dc.identifier.scopusauthoridYung, S=22636568800en_US
dc.identifier.scopusauthoridChao, TM=26967542800en_US

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