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- PMID: 17556337
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Conference Paper: Studying the effects of new peritoneal dialysis solutions on the peritoneum
Title | Studying the effects of new peritoneal dialysis solutions on the peritoneum |
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Authors | |
Keywords | Amino acid Bicarbonate Glucose Icodextrin Peritoneum |
Issue Date | 2007 |
Publisher | Multimed, Inc. The Journal's web site is located at http://pdiconnect.com |
Citation | The 11th Congress of the International Society of Peritoneal Dialysis, Hong Kong, 25–29 August 2006. In Peritoneal Dialysis International, 2007, v. 27 suppl. 2, p. S87-S93 How to Cite? |
Abstract | Background: Compelling data underscore the bioincompatible nature of glucose-based peritoneal dialysis (PD) solutions and their detrimental effects on peritoneal physiology and morphology. New PD solutions have been formulated to tackle common clinical problems such as inadequate ultrafiltration or malnutrition, and to improve biocompatibility - the latter aimed at preserving the structural and functional integrity of the peritoneum and reducing adverse systemic effects on the patient. Methods: This article reviews the factors in PD fluids that alter normal peritoneal anatomy and physiology, and the data that illustrate approaches to investigating the local and systemic biocompatibility of new PD solutions. Results: Chronic exposure of the peritoneal membrane to glucose-based PD solutions results in denudation of the mesothelium, thickened submesothelium, and hyalinization of the vasculature, often resulting in reduced or lost solute and water clearance. Data from in vitro or animal experiments and clinical studies have shown improved biocompatibility profiles with new PD solutions that are glucose-free (that is, dialysates with amino acids or icodextrin), bicarbonate-buffered, or compartmentalized during heat sterilization to reduce levels of glucose degradation products. Improved biocompatibility is denoted by reduced induction of proinflammatory, profibrotic, or angiogenic growth factors in mesothelial cells and macrophages, or by less perturbation of leukocyte phagocytic function. Conclusions: Data from in vitro and animal experiments show more favorable biocompatibility profiles with new PD fluids than with glucose-based dialysates. Clinical studies are ongoing to assess the impact of the new PD fluids on peritoneal function, morbidity, and mortality. Copyright © 2007 International Society for Peritoneal Dialysis. Printed in Canada. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/163569 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.933 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, TH | en_US |
dc.contributor.author | Yung, S | en_US |
dc.date.accessioned | 2012-09-05T05:37:28Z | - |
dc.date.available | 2012-09-05T05:37:28Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | The 11th Congress of the International Society of Peritoneal Dialysis, Hong Kong, 25–29 August 2006. In Peritoneal Dialysis International, 2007, v. 27 suppl. 2, p. S87-S93 | en_US |
dc.identifier.issn | 0896-8608 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/163569 | - |
dc.description.abstract | Background: Compelling data underscore the bioincompatible nature of glucose-based peritoneal dialysis (PD) solutions and their detrimental effects on peritoneal physiology and morphology. New PD solutions have been formulated to tackle common clinical problems such as inadequate ultrafiltration or malnutrition, and to improve biocompatibility - the latter aimed at preserving the structural and functional integrity of the peritoneum and reducing adverse systemic effects on the patient. Methods: This article reviews the factors in PD fluids that alter normal peritoneal anatomy and physiology, and the data that illustrate approaches to investigating the local and systemic biocompatibility of new PD solutions. Results: Chronic exposure of the peritoneal membrane to glucose-based PD solutions results in denudation of the mesothelium, thickened submesothelium, and hyalinization of the vasculature, often resulting in reduced or lost solute and water clearance. Data from in vitro or animal experiments and clinical studies have shown improved biocompatibility profiles with new PD solutions that are glucose-free (that is, dialysates with amino acids or icodextrin), bicarbonate-buffered, or compartmentalized during heat sterilization to reduce levels of glucose degradation products. Improved biocompatibility is denoted by reduced induction of proinflammatory, profibrotic, or angiogenic growth factors in mesothelial cells and macrophages, or by less perturbation of leukocyte phagocytic function. Conclusions: Data from in vitro and animal experiments show more favorable biocompatibility profiles with new PD fluids than with glucose-based dialysates. Clinical studies are ongoing to assess the impact of the new PD fluids on peritoneal function, morbidity, and mortality. Copyright © 2007 International Society for Peritoneal Dialysis. Printed in Canada. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Multimed, Inc. The Journal's web site is located at http://pdiconnect.com | en_US |
dc.relation.ispartof | Peritoneal Dialysis International | en_US |
dc.subject | Amino acid | - |
dc.subject | Bicarbonate | - |
dc.subject | Glucose | - |
dc.subject | Icodextrin | - |
dc.subject | Peritoneum | - |
dc.subject.mesh | Amino Acids | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bicarbonates | en_US |
dc.subject.mesh | Biocompatible Materials | en_US |
dc.subject.mesh | Buffers | en_US |
dc.subject.mesh | Dialysis Solutions - Chemistry - Pharmacology | en_US |
dc.subject.mesh | Glucans | en_US |
dc.subject.mesh | Glucose | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Peritoneal Dialysis | en_US |
dc.subject.mesh | Peritoneum - Drug Effects | en_US |
dc.title | Studying the effects of new peritoneal dialysis solutions on the peritoneum | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Chan, TH:dtmchan@hku.hk | en_US |
dc.identifier.email | Yung, S:ssyyung@hku.hk | en_US |
dc.identifier.authority | Chan, TH=rp00394 | en_US |
dc.identifier.authority | Yung, S=rp00455 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 17556337 | - |
dc.identifier.scopus | eid_2-s2.0-35748986444 | en_US |
dc.identifier.hkuros | 130440 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-35748986444&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | suppl. 2 | en_US |
dc.identifier.spage | S87 | en_US |
dc.identifier.epage | S93 | en_US |
dc.identifier.isi | WOS:000257889500017 | - |
dc.publisher.place | Canada | en_US |
dc.description.other | The 11th Congress of the International Society of Peritoneal Dialysis, Hong Kong, 25–29 August 2006. In Peritoneal Dialysis International, 2007, v. 27 SUPPL. 2, p. S87-S93 | - |
dc.identifier.scopusauthorid | Chan, TH=7402687700 | en_US |
dc.identifier.scopusauthorid | Yung, S=22636568800 | en_US |
dc.customcontrol.immutable | jt 130827 | - |
dc.identifier.issnl | 0896-8608 | - |