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Conference Paper: Glycosaminoglycans and proteoglycans: Overlooked entities?

TitleGlycosaminoglycans and proteoglycans: Overlooked entities?
Authors
Issue Date2007
PublisherMultimed, Inc. The Journal's web site is located at http://pdiconnect.com
Citation
The 11th Congress of the International Society of Peritoneal Dialysis, Hong Kong, 25–29 August 2006. In Peritoneal Dialysis International, 2007, v. 27 SUPPL. 2, p. S104-S109 How to Cite?
Abstract◆ Background: By virtue of their high net negative charge, glycosaminoglycans and proteoglycans play pivotal roles in biologic processes such as cell-cell and cell-matrix interactions, sequestration of growth factors, activation of chemokines and cytokines, and permselectivity of basement membranes. ◆ Methods: The present article reviews the putative roles of glycosaminoglycans and proteoglycans in the peritoneal cavity during normal peritoneal homeostasis and chronic inflammation, the latter induced by constant exposure of the peritoneum to non-physiologic peritoneal dialysis (PD) solutions. ◆ Results: Glycosaminoglycans have been identified in the mesothelial glycocalyx, a slippery, non-adhesive layer that protects the peritoneal membrane from abrasion and infection. Dermatan sulfate proteoglycans can neutralize the activity of transforming growth factor β1 and can thus play an essential role in modulating peritoneal fibrosis. Heparan sulfate proteoglycans play a crucial role in the sequestration of growth factors; they also modulate selective permeability of proteins across the peritoneal cavity. Reduced expression of perlecan, a heparan sulfate proteoglycan of the basement membrane, is observed in peritoneal biopsies obtained from established PD patients, consequent to prolonged exposure to the elevated glucose concentrations in conventional PD solutions. Supplementation of PD fluids with glycosaminoglycans has been shown to be beneficial to both the structural and functional integrity of the peritoneum. ◆ Conclusions: Recent advances in the field of glycobiology have revealed a multitude of biologic processes that are controlled or influenced by glycosaminoglycans and proteoglycans. Altered synthesis of these macromolecules during PD has serious implications for the peritoneal transport of proteins, host defense, wound healing, inflammation, and fibrosis. Copyright © 2007 International Society for Peritoneal Dialysis. Printed in Canada. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/163568
ISSN
2015 Impact Factor: 1.298
2015 SCImago Journal Rankings: 0.683
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYung, Sen_US
dc.contributor.authorChan, TMen_US
dc.date.accessioned2012-09-05T05:37:27Z-
dc.date.available2012-09-05T05:37:27Z-
dc.date.issued2007en_US
dc.identifier.citationThe 11th Congress of the International Society of Peritoneal Dialysis, Hong Kong, 25–29 August 2006. In Peritoneal Dialysis International, 2007, v. 27 SUPPL. 2, p. S104-S109en_US
dc.identifier.issn0896-8608en_US
dc.identifier.urihttp://hdl.handle.net/10722/163568-
dc.description.abstract◆ Background: By virtue of their high net negative charge, glycosaminoglycans and proteoglycans play pivotal roles in biologic processes such as cell-cell and cell-matrix interactions, sequestration of growth factors, activation of chemokines and cytokines, and permselectivity of basement membranes. ◆ Methods: The present article reviews the putative roles of glycosaminoglycans and proteoglycans in the peritoneal cavity during normal peritoneal homeostasis and chronic inflammation, the latter induced by constant exposure of the peritoneum to non-physiologic peritoneal dialysis (PD) solutions. ◆ Results: Glycosaminoglycans have been identified in the mesothelial glycocalyx, a slippery, non-adhesive layer that protects the peritoneal membrane from abrasion and infection. Dermatan sulfate proteoglycans can neutralize the activity of transforming growth factor β1 and can thus play an essential role in modulating peritoneal fibrosis. Heparan sulfate proteoglycans play a crucial role in the sequestration of growth factors; they also modulate selective permeability of proteins across the peritoneal cavity. Reduced expression of perlecan, a heparan sulfate proteoglycan of the basement membrane, is observed in peritoneal biopsies obtained from established PD patients, consequent to prolonged exposure to the elevated glucose concentrations in conventional PD solutions. Supplementation of PD fluids with glycosaminoglycans has been shown to be beneficial to both the structural and functional integrity of the peritoneum. ◆ Conclusions: Recent advances in the field of glycobiology have revealed a multitude of biologic processes that are controlled or influenced by glycosaminoglycans and proteoglycans. Altered synthesis of these macromolecules during PD has serious implications for the peritoneal transport of proteins, host defense, wound healing, inflammation, and fibrosis. Copyright © 2007 International Society for Peritoneal Dialysis. Printed in Canada. All rights reserved.en_US
dc.languageengen_US
dc.publisherMultimed, Inc. The Journal's web site is located at http://pdiconnect.comen_US
dc.relation.ispartofPeritoneal Dialysis Internationalen_US
dc.subject.meshDialysis Solutions - Pharmacologyen_US
dc.subject.meshEpithelial Cells - Physiologyen_US
dc.subject.meshFibrosisen_US
dc.subject.meshGlycosaminoglycans - Biosynthesis - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammation - Metabolismen_US
dc.subject.meshPeritoneal Dialysisen_US
dc.subject.meshPeritoneum - Pathology - Physiologyen_US
dc.subject.meshProteoglycans - Biosynthesis - Physiologyen_US
dc.titleGlycosaminoglycans and proteoglycans: Overlooked entities?en_US
dc.typeConference_Paperen_US
dc.identifier.emailYung, S:ssyyung@hku.hken_US
dc.identifier.emailChan, TM:dtmchan@hku.hken_US
dc.identifier.authorityYung, S=rp00455en_US
dc.identifier.authorityChan, TM=rp00394en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid17556287en_US
dc.identifier.scopuseid_2-s2.0-35748985291en_US
dc.identifier.hkuros130447-
dc.identifier.hkuros121659-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35748985291&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume27en_US
dc.identifier.issueSUPPL. 2en_US
dc.identifier.spageS104en_US
dc.identifier.epageS109en_US
dc.identifier.isiWOS:000257889500019-
dc.publisher.placeCanadaen_US
dc.description.otherThe 11th Congress of the International Society of Peritoneal Dialysis, Hong Kong, 25–29 August 2006. In Peritoneal Dialysis International, 2007, v. 27 SUPPL. 2, p. S104-S109-
dc.identifier.scopusauthoridYung, S=22636568800en_US
dc.identifier.scopusauthoridChan, TM=7402687700en_US
dc.customcontrol.immutablejt 130827-

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