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Conference Paper: Mesothelial cells

TitleMesothelial cells
Authors
Issue Date2007
PublisherMultimed, Inc. The Journal's web site is located at http://pdiconnect.com
Citation
The 11th Congress of the International Society of Peritoneal Dialysis, Hong Kong, 25–29 August 2006. In Peritoneal Dialysis International, 2007, v. 27 SUPPL. 2, p. S110-S115 How to Cite?
Abstract◆ Background: The introduction of peritoneal dialysis (PD) as a modality of renal replacement therapy has provoked much interest in the biology of the peritoneal mesothelial cell. Mesothelial cells isolated from omental tissue have immunohistochemical markers that are identical to those of mesothelial stem cells, and omental mesothelial cells can be cultivated in vitro to study changes to their biologic functions in the setting of PD. ◆ Method: The present article describes the structure and function of mesothelial cells in the normal peritoneum and details the morphologic changes that occur after the introduction of PD. Furthermore, this article reviews the literature of mesothelial cell culture and the limitations of in vitro studies. ◆ Results: The mesothelium is now considered to be a dynamic membrane that plays a pivotal role in the homeostasis of the peritoneal cavity, contributing to the control of fluid and solute transport, inflammation, and wound healing. These functional properties of the mesothelium are compromised in the setting of PD. Cultures of peritoneal mesothelial cells from omental tissue provide a relevant in vitro model that allows researchers to assess specific molecular pathways of disease in a distinct population of cells. Structural and functional attributes of mesothelial cells are discussed in relation to long-term culture, proliferation potential, age of tissue donor, use of human or animal in vitro models, and how the foregoing factors may influence in vitro data. ◆ Conclusions: The ability to propagate mesothelial cells in culture has resulted, over the past two decades, in an explosion of mesothelial cell research pertaining to PD and peritoneal disorders. Independent researchers have highlighted the potential use of mesothelial cells as targets for gene therapy or transplantation in the search to provide therapeutic strategies for the preservation of the mesothelium during chemical or bacterial injury. Copyright © 2007 International Society for Peritoneal Dialysis. Printed in Canada. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/163567
ISSN
2015 Impact Factor: 1.298
2015 SCImago Journal Rankings: 0.683
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYung, Sen_US
dc.contributor.authorChan, TMen_US
dc.date.accessioned2012-09-05T05:37:26Z-
dc.date.available2012-09-05T05:37:26Z-
dc.date.issued2007en_US
dc.identifier.citationThe 11th Congress of the International Society of Peritoneal Dialysis, Hong Kong, 25–29 August 2006. In Peritoneal Dialysis International, 2007, v. 27 SUPPL. 2, p. S110-S115en_US
dc.identifier.issn0896-8608en_US
dc.identifier.urihttp://hdl.handle.net/10722/163567-
dc.description.abstract◆ Background: The introduction of peritoneal dialysis (PD) as a modality of renal replacement therapy has provoked much interest in the biology of the peritoneal mesothelial cell. Mesothelial cells isolated from omental tissue have immunohistochemical markers that are identical to those of mesothelial stem cells, and omental mesothelial cells can be cultivated in vitro to study changes to their biologic functions in the setting of PD. ◆ Method: The present article describes the structure and function of mesothelial cells in the normal peritoneum and details the morphologic changes that occur after the introduction of PD. Furthermore, this article reviews the literature of mesothelial cell culture and the limitations of in vitro studies. ◆ Results: The mesothelium is now considered to be a dynamic membrane that plays a pivotal role in the homeostasis of the peritoneal cavity, contributing to the control of fluid and solute transport, inflammation, and wound healing. These functional properties of the mesothelium are compromised in the setting of PD. Cultures of peritoneal mesothelial cells from omental tissue provide a relevant in vitro model that allows researchers to assess specific molecular pathways of disease in a distinct population of cells. Structural and functional attributes of mesothelial cells are discussed in relation to long-term culture, proliferation potential, age of tissue donor, use of human or animal in vitro models, and how the foregoing factors may influence in vitro data. ◆ Conclusions: The ability to propagate mesothelial cells in culture has resulted, over the past two decades, in an explosion of mesothelial cell research pertaining to PD and peritoneal disorders. Independent researchers have highlighted the potential use of mesothelial cells as targets for gene therapy or transplantation in the search to provide therapeutic strategies for the preservation of the mesothelium during chemical or bacterial injury. Copyright © 2007 International Society for Peritoneal Dialysis. Printed in Canada. All rights reserved.en_US
dc.languageengen_US
dc.publisherMultimed, Inc. The Journal's web site is located at http://pdiconnect.comen_US
dc.relation.ispartofPeritoneal Dialysis Internationalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Culture Techniquesen_US
dc.subject.meshCell Differentiationen_US
dc.subject.meshEpithelial Cells - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Failure, Chronic - Pathology - Therapyen_US
dc.subject.meshPeritoneal Dialysisen_US
dc.subject.meshPeritoneum - Cytologyen_US
dc.titleMesothelial cellsen_US
dc.typeConference_Paperen_US
dc.identifier.emailYung, S:ssyyung@hku.hken_US
dc.identifier.emailChan, TM:dtmchan@hku.hken_US
dc.identifier.authorityYung, S=rp00455en_US
dc.identifier.authorityChan, TM=rp00394en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid17556288-
dc.identifier.scopuseid_2-s2.0-35748974230en_US
dc.identifier.hkuros121658-
dc.identifier.hkuros130443-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35748974230&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume27en_US
dc.identifier.issueSUPPL. 2en_US
dc.identifier.spageS110en_US
dc.identifier.epageS115en_US
dc.identifier.isiWOS:000257889500020-
dc.publisher.placeCanadaen_US
dc.description.otherThe 11th Congress of the International Society of Peritoneal Dialysis, Hong Kong, 25–29 August 2006. In Peritoneal Dialysis International, 2007, v. 27 SUPPL. 2, p. S110-S115-
dc.identifier.scopusauthoridYung, S=22636568800en_US
dc.identifier.scopusauthoridChan, TM=7402687700en_US
dc.customcontrol.immutablejt 130827-

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