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- Scopus: eid_2-s2.0-35748974230
- PMID: 17556288
- WOS: WOS:000257889500020
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Conference Paper: Mesothelial cells
Title | Mesothelial cells |
---|---|
Authors | |
Keywords | Mesothelial cells Omentum Peritoneum Proliferation Senescence |
Issue Date | 2007 |
Publisher | Multimed, Inc. The Journal's web site is located at http://pdiconnect.com |
Citation | The 11th Congress of the International Society of Peritoneal Dialysis, Hong Kong, 25–29 August 2006. In Peritoneal Dialysis International, 2007, v. 27 suppl. 2, p. S110-S115 How to Cite? |
Abstract | Background: The introduction of peritoneal dialysis (PD) as a modality of renal replacement therapy has provoked much interest in the biology of the peritoneal mesothelial cell. Mesothelial cells isolated from omental tissue have immunohistochemical markers that are identical to those of mesothelial stem cells, and omental mesothelial cells can be cultivated in vitro to study changes to their biologic functions in the setting of PD. Method: The present article describes the structure and function of mesothelial cells in the normal peritoneum and details the morphologic changes that occur after the introduction of PD. Furthermore, this article reviews the literature of mesothelial cell culture and the limitations of in vitro studies. Results: The mesothelium is now considered to be a dynamic membrane that plays a pivotal role in the homeostasis of the peritoneal cavity, contributing to the control of fluid and solute transport, inflammation, and wound healing. These functional properties of the mesothelium are compromised in the setting of PD. Cultures of peritoneal mesothelial cells from omental tissue provide a relevant in vitro model that allows researchers to assess specific molecular pathways of disease in a distinct population of cells. Structural and functional attributes of mesothelial cells are discussed in relation to long-term culture, proliferation potential, age of tissue donor, use of human or animal in vitro models, and how the foregoing factors may influence in vitro data. Conclusions: The ability to propagate mesothelial cells in culture has resulted, over the past two decades, in an explosion of mesothelial cell research pertaining to PD and peritoneal disorders. Independent researchers have highlighted the potential use of mesothelial cells as targets for gene therapy or transplantation in the search to provide therapeutic strategies for the preservation of the mesothelium during chemical or bacterial injury. Copyright © 2007 International Society for Peritoneal Dialysis. Printed in Canada. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/163567 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.933 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yung, S | en_US |
dc.contributor.author | Chan, TM | en_US |
dc.date.accessioned | 2012-09-05T05:37:26Z | - |
dc.date.available | 2012-09-05T05:37:26Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | The 11th Congress of the International Society of Peritoneal Dialysis, Hong Kong, 25–29 August 2006. In Peritoneal Dialysis International, 2007, v. 27 suppl. 2, p. S110-S115 | en_US |
dc.identifier.issn | 0896-8608 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/163567 | - |
dc.description.abstract | Background: The introduction of peritoneal dialysis (PD) as a modality of renal replacement therapy has provoked much interest in the biology of the peritoneal mesothelial cell. Mesothelial cells isolated from omental tissue have immunohistochemical markers that are identical to those of mesothelial stem cells, and omental mesothelial cells can be cultivated in vitro to study changes to their biologic functions in the setting of PD. Method: The present article describes the structure and function of mesothelial cells in the normal peritoneum and details the morphologic changes that occur after the introduction of PD. Furthermore, this article reviews the literature of mesothelial cell culture and the limitations of in vitro studies. Results: The mesothelium is now considered to be a dynamic membrane that plays a pivotal role in the homeostasis of the peritoneal cavity, contributing to the control of fluid and solute transport, inflammation, and wound healing. These functional properties of the mesothelium are compromised in the setting of PD. Cultures of peritoneal mesothelial cells from omental tissue provide a relevant in vitro model that allows researchers to assess specific molecular pathways of disease in a distinct population of cells. Structural and functional attributes of mesothelial cells are discussed in relation to long-term culture, proliferation potential, age of tissue donor, use of human or animal in vitro models, and how the foregoing factors may influence in vitro data. Conclusions: The ability to propagate mesothelial cells in culture has resulted, over the past two decades, in an explosion of mesothelial cell research pertaining to PD and peritoneal disorders. Independent researchers have highlighted the potential use of mesothelial cells as targets for gene therapy or transplantation in the search to provide therapeutic strategies for the preservation of the mesothelium during chemical or bacterial injury. Copyright © 2007 International Society for Peritoneal Dialysis. Printed in Canada. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Multimed, Inc. The Journal's web site is located at http://pdiconnect.com | en_US |
dc.relation.ispartof | Peritoneal Dialysis International | en_US |
dc.subject | Mesothelial cells | - |
dc.subject | Omentum | - |
dc.subject | Peritoneum | - |
dc.subject | Proliferation | - |
dc.subject | Senescence | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cell Culture Techniques | en_US |
dc.subject.mesh | Cell Differentiation | en_US |
dc.subject.mesh | Epithelial Cells - Physiology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Kidney Failure, Chronic - Pathology - Therapy | en_US |
dc.subject.mesh | Peritoneal Dialysis | en_US |
dc.subject.mesh | Peritoneum - Cytology | en_US |
dc.title | Mesothelial cells | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Yung, S:ssyyung@hku.hk | en_US |
dc.identifier.email | Chan, TM:dtmchan@hku.hk | en_US |
dc.identifier.authority | Yung, S=rp00455 | en_US |
dc.identifier.authority | Chan, TM=rp00394 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 17556288 | - |
dc.identifier.scopus | eid_2-s2.0-35748974230 | en_US |
dc.identifier.hkuros | 121658 | - |
dc.identifier.hkuros | 130443 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-35748974230&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | suppl. 2 | en_US |
dc.identifier.spage | S110 | en_US |
dc.identifier.epage | S115 | en_US |
dc.identifier.isi | WOS:000257889500020 | - |
dc.publisher.place | Canada | en_US |
dc.description.other | The 11th Congress of the International Society of Peritoneal Dialysis, Hong Kong, 25–29 August 2006. In Peritoneal Dialysis International, 2007, v. 27 SUPPL. 2, p. S110-S115 | - |
dc.identifier.scopusauthorid | Yung, S=22636568800 | en_US |
dc.identifier.scopusauthorid | Chan, TM=7402687700 | en_US |
dc.customcontrol.immutable | jt 130827 | - |
dc.identifier.issnl | 0896-8608 | - |