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- Publisher Website: 10.1046/j.1365-2893.2003.00453.x-i1
- Scopus: eid_2-s2.0-35448983168
- PMID: 17958636
- WOS: WOS:000250824700003
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Conference Paper: The natural history of chronic hepatitis B
Title | The natural history of chronic hepatitis B |
---|---|
Authors | |
Keywords | ALT Cirrhosis HBeAg serconversion HBV DNA Hepatocellular carcinoma |
Issue Date | 2007 |
Citation | Journal Of Viral Hepatitis, 2007, v. 14 SUPPL. 1, p. 6-10 How to Cite? |
Abstract | The natural history of chronic hepatitis B is dependent on the age of acquiring the hepatitis B infection. Those who are infected at adolescence or adulthood (including most of the Caucasians) tend to have stable disease after hepatitis B e antigen seroconversion with normal serum alanine aminotransaminase (ALT) and hepatitis B virus (HBV) DNA levels <105 copies/mL (20 000 IU/mL). In contrast, those who are infected at birth or early childhood (including the majority of the world's hepatitis B carriers, i.e. Asians) have a prolonged immune tolerance phase followed by a prolonged immune clearance phase. A proportion of these patients have progressive disease after HBeAg seroconversion with HBV DNA <104 copies/mL (<2000 IU/mL) and ALT between 0.5 and 2× upper limit of normal. Core promoter mutations may play a part in the development of cirrhosis-related complications. However, continuing viral replication, even at a relatively low level of <10 4 copies/mL (<2000 IU/mL), is probably the most important factor for the development of complications. © 2007 The Authors. |
Persistent Identifier | http://hdl.handle.net/10722/163566 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 1.078 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lai, CL | en_US |
dc.contributor.author | Yuen, MF | en_US |
dc.date.accessioned | 2012-09-05T05:37:26Z | - |
dc.date.available | 2012-09-05T05:37:26Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Journal Of Viral Hepatitis, 2007, v. 14 SUPPL. 1, p. 6-10 | en_US |
dc.identifier.issn | 1352-0504 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/163566 | - |
dc.description.abstract | The natural history of chronic hepatitis B is dependent on the age of acquiring the hepatitis B infection. Those who are infected at adolescence or adulthood (including most of the Caucasians) tend to have stable disease after hepatitis B e antigen seroconversion with normal serum alanine aminotransaminase (ALT) and hepatitis B virus (HBV) DNA levels <105 copies/mL (20 000 IU/mL). In contrast, those who are infected at birth or early childhood (including the majority of the world's hepatitis B carriers, i.e. Asians) have a prolonged immune tolerance phase followed by a prolonged immune clearance phase. A proportion of these patients have progressive disease after HBeAg seroconversion with HBV DNA <104 copies/mL (<2000 IU/mL) and ALT between 0.5 and 2× upper limit of normal. Core promoter mutations may play a part in the development of cirrhosis-related complications. However, continuing viral replication, even at a relatively low level of <10 4 copies/mL (<2000 IU/mL), is probably the most important factor for the development of complications. © 2007 The Authors. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Journal of Viral Hepatitis | en_US |
dc.rights | Journal of Viral Hepatitis. Copyright © Blackwell Publishing Ltd. | - |
dc.subject | ALT | - |
dc.subject | Cirrhosis | - |
dc.subject | HBeAg serconversion | - |
dc.subject | HBV DNA | - |
dc.subject | Hepatocellular carcinoma | - |
dc.subject.mesh | Age Factors | en_US |
dc.subject.mesh | Hepatitis B Antibodies - Immunology | en_US |
dc.subject.mesh | Hepatitis B E Antigens - Immunology | en_US |
dc.subject.mesh | Hepatitis B, Chronic - Immunology - Pathology - Virology | en_US |
dc.subject.mesh | Humans | en_US |
dc.title | The natural history of chronic hepatitis B | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Lai, CL:hrmelcl@hku.hk | en_US |
dc.identifier.email | Yuen, MF:mfyuen@hkucc.hku.hk | en_US |
dc.identifier.authority | Lai, CL=rp00314 | en_US |
dc.identifier.authority | Yuen, MF=rp00479 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1046/j.1365-2893.2003.00453.x-i1 | - |
dc.identifier.pmid | 17958636 | - |
dc.identifier.scopus | eid_2-s2.0-35448983168 | en_US |
dc.identifier.hkuros | 149098 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-35448983168&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | SUPPL. 1 | en_US |
dc.identifier.spage | 6 | en_US |
dc.identifier.epage | 10 | en_US |
dc.identifier.isi | WOS:000250824700003 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Lai, CL=7403086396 | en_US |
dc.identifier.scopusauthorid | Yuen, MF=7102031955 | en_US |
dc.identifier.citeulike | 1569857 | - |
dc.identifier.issnl | 1352-0504 | - |