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Conference Paper: The natural history of chronic hepatitis B

TitleThe natural history of chronic hepatitis B
Authors
Issue Date2007
Citation
Journal Of Viral Hepatitis, 2007, v. 14 SUPPL. 1, p. 6-10 How to Cite?
AbstractThe natural history of chronic hepatitis B is dependent on the age of acquiring the hepatitis B infection. Those who are infected at adolescence or adulthood (including most of the Caucasians) tend to have stable disease after hepatitis B e antigen seroconversion with normal serum alanine aminotransaminase (ALT) and hepatitis B virus (HBV) DNA levels <105 copies/mL (20 000 IU/mL). In contrast, those who are infected at birth or early childhood (including the majority of the world's hepatitis B carriers, i.e. Asians) have a prolonged immune tolerance phase followed by a prolonged immune clearance phase. A proportion of these patients have progressive disease after HBeAg seroconversion with HBV DNA <104 copies/mL (<2000 IU/mL) and ALT between 0.5 and 2× upper limit of normal. Core promoter mutations may play a part in the development of cirrhosis-related complications. However, continuing viral replication, even at a relatively low level of <10 4 copies/mL (<2000 IU/mL), is probably the most important factor for the development of complications. © 2007 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/163566
ISSN
2015 Impact Factor: 4.179
2015 SCImago Journal Rankings: 1.815
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, CLen_US
dc.contributor.authorYuen, MFen_US
dc.date.accessioned2012-09-05T05:37:26Z-
dc.date.available2012-09-05T05:37:26Z-
dc.date.issued2007en_US
dc.identifier.citationJournal Of Viral Hepatitis, 2007, v. 14 SUPPL. 1, p. 6-10en_US
dc.identifier.issn1352-0504en_US
dc.identifier.urihttp://hdl.handle.net/10722/163566-
dc.description.abstractThe natural history of chronic hepatitis B is dependent on the age of acquiring the hepatitis B infection. Those who are infected at adolescence or adulthood (including most of the Caucasians) tend to have stable disease after hepatitis B e antigen seroconversion with normal serum alanine aminotransaminase (ALT) and hepatitis B virus (HBV) DNA levels <105 copies/mL (20 000 IU/mL). In contrast, those who are infected at birth or early childhood (including the majority of the world's hepatitis B carriers, i.e. Asians) have a prolonged immune tolerance phase followed by a prolonged immune clearance phase. A proportion of these patients have progressive disease after HBeAg seroconversion with HBV DNA <104 copies/mL (<2000 IU/mL) and ALT between 0.5 and 2× upper limit of normal. Core promoter mutations may play a part in the development of cirrhosis-related complications. However, continuing viral replication, even at a relatively low level of <10 4 copies/mL (<2000 IU/mL), is probably the most important factor for the development of complications. © 2007 The Authors.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Viral Hepatitisen_US
dc.rightsJournal of Viral Hepatitis. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAge Factorsen_US
dc.subject.meshHepatitis B Antibodies - Immunologyen_US
dc.subject.meshHepatitis B E Antigens - Immunologyen_US
dc.subject.meshHepatitis B, Chronic - Immunology - Pathology - Virologyen_US
dc.subject.meshHumansen_US
dc.titleThe natural history of chronic hepatitis Ben_US
dc.typeConference_Paperen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.identifier.authorityYuen, MF=rp00479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2893.2007.00909.xen_US
dc.identifier.doi10.1046/j.1365-2893.2003.00453.x-i1-
dc.identifier.pmid17958636-
dc.identifier.scopuseid_2-s2.0-35448983168en_US
dc.identifier.hkuros149098-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35448983168&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issueSUPPL. 1en_US
dc.identifier.spage6en_US
dc.identifier.epage10en_US
dc.identifier.isiWOS:000250824700003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridYuen, MF=7102031955en_US
dc.identifier.citeulike1569857-

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