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Conference Paper: Vasoactive intestinal peptide in the hypothalamus and pituitary

TitleVasoactive intestinal peptide in the hypothalamus and pituitary
Authors
Issue Date1991
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEN
Citation
Neuroendocrinology, 1991, v. 53 SUPPL. 1, p. 45-51 How to Cite?
AbstractData are presented to show that vasoactive intestinal peptide (VIP) is synthesized and secreted by the hypothalamus and anterior pituitary and that it participates in the regulation of pituitary functions. Immunoreactive VIP in the hypothalamus and pituitary is increased following estrogen treatment and adrenalectomy and is reduced in hyperprolactinemic states. The level of VIP mRNA in the hypothalamus is increased during lactation and sexual maturation, while that in the anterior pituitary shows a sexual dimorphism and is increased with estrogen treatment and hypothyroidism. All these findings suggest a physiological regulation of hypothalamic and pituitary VIP gene expression in relation to its potential role as a neuroendocrine hormone. Furthermore, VIP stimulates prolactin (PRL) release at concentrations attainable in the hypophyseal-portal blood. Passive immunoneutralization studies with anti-VIP antisera suggest that endogenous VIP acts as multiple loci in the hypothalamic-pituitary axis to regulate PRL secretion, interacting possibly with other regulators of PRL secretion such as estrogen, serotonin, cholecystokinin, prostaglandins, galanin and oxytocin. Regarding other pituitary functions, although VIP has been shown to release growth hormone, ACTH, and vasopressin in vivo and in vitro, the physiological significance of these findings remains to be determined.
Persistent Identifierhttp://hdl.handle.net/10722/163529
ISSN
2015 Impact Factor: 2.583
2015 SCImago Journal Rankings: 1.479
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, KSLen_US
dc.date.accessioned2012-09-05T05:37:05Z-
dc.date.available2012-09-05T05:37:05Z-
dc.date.issued1991en_US
dc.identifier.citationNeuroendocrinology, 1991, v. 53 SUPPL. 1, p. 45-51en_US
dc.identifier.issn0028-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/163529-
dc.description.abstractData are presented to show that vasoactive intestinal peptide (VIP) is synthesized and secreted by the hypothalamus and anterior pituitary and that it participates in the regulation of pituitary functions. Immunoreactive VIP in the hypothalamus and pituitary is increased following estrogen treatment and adrenalectomy and is reduced in hyperprolactinemic states. The level of VIP mRNA in the hypothalamus is increased during lactation and sexual maturation, while that in the anterior pituitary shows a sexual dimorphism and is increased with estrogen treatment and hypothyroidism. All these findings suggest a physiological regulation of hypothalamic and pituitary VIP gene expression in relation to its potential role as a neuroendocrine hormone. Furthermore, VIP stimulates prolactin (PRL) release at concentrations attainable in the hypophyseal-portal blood. Passive immunoneutralization studies with anti-VIP antisera suggest that endogenous VIP acts as multiple loci in the hypothalamic-pituitary axis to regulate PRL secretion, interacting possibly with other regulators of PRL secretion such as estrogen, serotonin, cholecystokinin, prostaglandins, galanin and oxytocin. Regarding other pituitary functions, although VIP has been shown to release growth hormone, ACTH, and vasopressin in vivo and in vitro, the physiological significance of these findings remains to be determined.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NENen_US
dc.relation.ispartofNeuroendocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshHumansen_US
dc.subject.meshHypothalamus - Chemistry - Physiologyen_US
dc.subject.meshPituitary Gland - Chemistry - Physiologyen_US
dc.subject.meshPituitary Hormones - Secretionen_US
dc.subject.meshProlactin - Secretionen_US
dc.subject.meshVasoactive Intestinal Peptide - Analysis - Physiologyen_US
dc.titleVasoactive intestinal peptide in the hypothalamus and pituitaryen_US
dc.typeConference_Paperen_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000125795-
dc.identifier.pmid1901391-
dc.identifier.scopuseid_2-s2.0-0025957286en_US
dc.identifier.volume53en_US
dc.identifier.issueSUPPL. 1en_US
dc.identifier.spage45en_US
dc.identifier.epage51en_US
dc.identifier.isiWOS:A1991EY58700009-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridLam, KSL=8082870600en_US

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