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Article: Autoantibodies and resident renal cells in the pathogenesis of lupus nephritis: Getting to know the unknown

TitleAutoantibodies and resident renal cells in the pathogenesis of lupus nephritis: Getting to know the unknown
Authors
Issue Date2012
PublisherTaylor & Francis Ltd. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/17402522.asp
Citation
Clinical And Developmental Immunology, 2012, v. 2012 How to Cite?
AbstractSystemic lupus erythematosus is characterized by a breakdown of self-tolerance and production of autoantibodies. Kidney involvement (i.e., lupus nephritis) is both common and severe and can result in permanent damage within the glomerular, vascular, and tubulo-interstitial compartments of the kidney, leading to acute or chronic renal failure. Accumulating evidence shows that anti-dsDNA antibodies play a critical role in the pathogenesis of lupus nephritis through their binding to cell surface proteins of resident kidney cells, thereby triggering the downstream activation of signaling pathways and the release of mediators of inflammation and fibrosis. This paper describes the mechanisms through which autoantibodies interact with resident renal cells and how this interaction plays a part in disease pathogenesis that ultimately leads to structural and functional alterations in lupus nephritis. Copyright © 2012 Susan Yung and Tak Mao Chan.
Persistent Identifierhttp://hdl.handle.net/10722/163512
ISSN
2015 Impact Factor: 3.603
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYung, Sen_US
dc.contributor.authorChan, TMen_US
dc.date.accessioned2012-09-05T05:32:51Z-
dc.date.available2012-09-05T05:32:51Z-
dc.date.issued2012en_US
dc.identifier.citationClinical And Developmental Immunology, 2012, v. 2012en_US
dc.identifier.issn1740-2522en_US
dc.identifier.urihttp://hdl.handle.net/10722/163512-
dc.description.abstractSystemic lupus erythematosus is characterized by a breakdown of self-tolerance and production of autoantibodies. Kidney involvement (i.e., lupus nephritis) is both common and severe and can result in permanent damage within the glomerular, vascular, and tubulo-interstitial compartments of the kidney, leading to acute or chronic renal failure. Accumulating evidence shows that anti-dsDNA antibodies play a critical role in the pathogenesis of lupus nephritis through their binding to cell surface proteins of resident kidney cells, thereby triggering the downstream activation of signaling pathways and the release of mediators of inflammation and fibrosis. This paper describes the mechanisms through which autoantibodies interact with resident renal cells and how this interaction plays a part in disease pathogenesis that ultimately leads to structural and functional alterations in lupus nephritis. Copyright © 2012 Susan Yung and Tak Mao Chan.en_US
dc.languageengen_US
dc.publisherTaylor & Francis Ltd. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/17402522.aspen_US
dc.relation.ispartofClinical and Developmental Immunologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleAutoantibodies and resident renal cells in the pathogenesis of lupus nephritis: Getting to know the unknownen_US
dc.typeArticleen_US
dc.identifier.emailYung, S:ssyyung@hku.hken_US
dc.identifier.emailChan, TM:dtmchan@hku.hken_US
dc.identifier.authorityYung, S=rp00455en_US
dc.identifier.authorityChan, TM=rp00394en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2012/139365en_US
dc.identifier.pmid22761629-
dc.identifier.scopuseid_2-s2.0-84863664311en_US
dc.identifier.hkuros204917-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863664311&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2012en_US
dc.identifier.isiWOS:000305641200001-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYung, S=22636568800en_US
dc.identifier.scopusauthoridChan, TM=7402687700en_US

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