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Article: Acute-on-chronic liver failure in chronic hepatitis B
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TitleAcute-on-chronic liver failure in chronic hepatitis B
 
AuthorsSeto, WK1
Lai, CL1
Yuen, MF1
 
KeywordsAcute-On-Chronic Liver Failure
Hepatitis B
Hepatitis B Virus Dna
Liver Failure
Model Of End-Stage Liver Disease
Survival
 
Issue Date2012
 
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
 
CitationJournal Of Gastroenterology And Hepatology, 2012, v. 27 n. 4, p. 662-669 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1440-1746.2011.06971.x
 
AbstractAcute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) is most commonly caused by acute severe exacerbation of CHB. The pathophysiology of ACLF in CHB is still poorly understood. Despite the identification of important predisposing factors and prognostic markers, ACLF in CHB remains a disease associated with high mortality. The majority of studies using nucleoside analog therapy did not show any significant improvement in survival, although larger prospective studies are needed. Liver transplantation is the definitive treatment for ACLF in CHB. The challenge ahead would be prognosticating cases with favorable or unfavorable outcomes in order to streamline patients for early transplantation or for medical therapy. © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
 
ISSN0815-9319
2012 Impact Factor: 3.325
2012 SCImago Journal Rankings: 0.985
 
DOIhttp://dx.doi.org/10.1111/j.1440-1746.2011.06971.x
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSeto, WK
 
dc.contributor.authorLai, CL
 
dc.contributor.authorYuen, MF
 
dc.date.accessioned2012-09-05T05:31:45Z
 
dc.date.available2012-09-05T05:31:45Z
 
dc.date.issued2012
 
dc.description.abstractAcute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) is most commonly caused by acute severe exacerbation of CHB. The pathophysiology of ACLF in CHB is still poorly understood. Despite the identification of important predisposing factors and prognostic markers, ACLF in CHB remains a disease associated with high mortality. The majority of studies using nucleoside analog therapy did not show any significant improvement in survival, although larger prospective studies are needed. Liver transplantation is the definitive treatment for ACLF in CHB. The challenge ahead would be prognosticating cases with favorable or unfavorable outcomes in order to streamline patients for early transplantation or for medical therapy. © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
 
dc.description.natureLink_to_OA_fulltext
 
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2012, v. 27 n. 4, p. 662-669 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1440-1746.2011.06971.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1440-1746.2011.06971.x
 
dc.identifier.epage669
 
dc.identifier.hkuros210697
 
dc.identifier.hkuros208907
 
dc.identifier.issn0815-9319
2012 Impact Factor: 3.325
2012 SCImago Journal Rankings: 0.985
 
dc.identifier.issue4
 
dc.identifier.pmid22098452
 
dc.identifier.scopuseid_2-s2.0-84858805271
 
dc.identifier.spage662
 
dc.identifier.urihttp://hdl.handle.net/10722/163470
 
dc.identifier.volume27
 
dc.languageeng
 
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
 
dc.publisher.placeAustralia
 
dc.relation.ispartofJournal of Gastroenterology and Hepatology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshDisease Progression
 
dc.subject.meshEnd Stage Liver Disease - etiology - therapy
 
dc.subject.meshHepatitis B, Chronic - complications - virology
 
dc.subject.meshHumans
 
dc.subject.meshLiver Failure, Acute - etiology - therapy
 
dc.subject.meshPrognosis
 
dc.subjectAcute-On-Chronic Liver Failure
 
dc.subjectHepatitis B
 
dc.subjectHepatitis B Virus Dna
 
dc.subjectLiver Failure
 
dc.subjectModel Of End-Stage Liver Disease
 
dc.subjectSurvival
 
dc.titleAcute-on-chronic liver failure in chronic hepatitis B
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong