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Article: Acute-on-chronic liver failure in chronic hepatitis B

TitleAcute-on-chronic liver failure in chronic hepatitis B
Authors
KeywordsAcute-On-Chronic Liver Failure
Hepatitis B
Hepatitis B Virus Dna
Liver Failure
Model Of End-Stage Liver Disease
Survival
Issue Date2012
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 2012, v. 27 n. 4, p. 662-669 How to Cite?
AbstractAcute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) is most commonly caused by acute severe exacerbation of CHB. The pathophysiology of ACLF in CHB is still poorly understood. Despite the identification of important predisposing factors and prognostic markers, ACLF in CHB remains a disease associated with high mortality. The majority of studies using nucleoside analog therapy did not show any significant improvement in survival, although larger prospective studies are needed. Liver transplantation is the definitive treatment for ACLF in CHB. The challenge ahead would be prognosticating cases with favorable or unfavorable outcomes in order to streamline patients for early transplantation or for medical therapy. © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/163470
ISSN
2014 Impact Factor: 3.504
2014 SCImago Journal Rankings: 1.128
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSeto, WKen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorYuen, MFen_HK
dc.date.accessioned2012-09-05T05:31:45Z-
dc.date.available2012-09-05T05:31:45Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2012, v. 27 n. 4, p. 662-669en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163470-
dc.description.abstractAcute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) is most commonly caused by acute severe exacerbation of CHB. The pathophysiology of ACLF in CHB is still poorly understood. Despite the identification of important predisposing factors and prognostic markers, ACLF in CHB remains a disease associated with high mortality. The majority of studies using nucleoside analog therapy did not show any significant improvement in survival, although larger prospective studies are needed. Liver transplantation is the definitive treatment for ACLF in CHB. The challenge ahead would be prognosticating cases with favorable or unfavorable outcomes in order to streamline patients for early transplantation or for medical therapy. © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.subjectAcute-On-Chronic Liver Failureen_US
dc.subjectHepatitis Ben_US
dc.subjectHepatitis B Virus Dnaen_US
dc.subjectLiver Failureen_US
dc.subjectModel Of End-Stage Liver Diseaseen_US
dc.subjectSurvivalen_US
dc.subject.meshDisease Progressionen_HK
dc.subject.meshEnd Stage Liver Disease - etiology - therapyen_HK
dc.subject.meshHepatitis B, Chronic - complications - virologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Failure, Acute - etiology - therapyen_HK
dc.subject.meshPrognosisen_HK
dc.titleAcute-on-chronic liver failure in chronic hepatitis Ben_HK
dc.typeArticleen_HK
dc.identifier.emailSeto, WK: wkseto2@hku.hken_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailYuen, MF: mfyuen@hku.hken_HK
dc.identifier.authoritySeto, WK=rp01659en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1111/j.1440-1746.2011.06971.xen_HK
dc.identifier.pmid22098452en_HK
dc.identifier.scopuseid_2-s2.0-84858805271en_HK
dc.identifier.hkuros210697-
dc.identifier.hkuros208907-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84858805271&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue4en_HK
dc.identifier.spage662en_HK
dc.identifier.epage669en_HK
dc.identifier.isiWOS:000301924800008-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridSeto, WK=23390675900en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK

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