Article: Acute-on-chronic liver failure in chronic hepatitis B

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Publisher Website: 10.1111/j.1440-1746.2011.06971.x
Scopus: eid_2-s2.0-84858805271
PMID: 22098452

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Title	Acute-on-chronic liver failure in chronic hepatitis B
Authors	Seto, WK1 Lai, CL1 Yuen, MF1
Keywords	Acute-On-Chronic Liver Failure Hepatitis B Hepatitis B Virus Dna Liver Failure Model Of End-Stage Liver Disease Survival
Issue Date	2012
Publisher	Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation	Journal Of Gastroenterology And Hepatology, 2012, v. 27 n. 4, p. 662-669 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1440-1746.2011.06971.x
Abstract	Acute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) is most commonly caused by acute severe exacerbation of CHB. The pathophysiology of ACLF in CHB is still poorly understood. Despite the identification of important predisposing factors and prognostic markers, ACLF in CHB remains a disease associated with high mortality. The majority of studies using nucleoside analog therapy did not show any significant improvement in survival, although larger prospective studies are needed. Liver transplantation is the definitive treatment for ACLF in CHB. The challenge ahead would be prognosticating cases with favorable or unfavorable outcomes in order to streamline patients for early transplantation or for medical therapy. © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
ISSN	0815-9319 2011 Impact Factor: 2.865 2011 SCImago Journal Rankings: 0.208
DOI	http://dx.doi.org/10.1111/j.1440-1746.2011.06971.x
References	References in Scopus

DC Field	Value
dc.contributor.author	Seto, WK
dc.contributor.author	Lai, CL
dc.contributor.author	Yuen, MF
dc.date.accessioned	2012-09-05T05:31:45Z
dc.date.available	2012-09-05T05:31:45Z
dc.date.issued	2012
dc.description.abstract	Acute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) is most commonly caused by acute severe exacerbation of CHB. The pathophysiology of ACLF in CHB is still poorly understood. Despite the identification of important predisposing factors and prognostic markers, ACLF in CHB remains a disease associated with high mortality. The majority of studies using nucleoside analog therapy did not show any significant improvement in survival, although larger prospective studies are needed. Liver transplantation is the definitive treatment for ACLF in CHB. The challenge ahead would be prognosticating cases with favorable or unfavorable outcomes in order to streamline patients for early transplantation or for medical therapy. © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
dc.description.nature	Link_to_OA_fulltext
dc.identifier.citation	Journal Of Gastroenterology And Hepatology, 2012, v. 27 n. 4, p. 662-669 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1440-1746.2011.06971.x
dc.identifier.doi	http://dx.doi.org/10.1111/j.1440-1746.2011.06971.x
dc.identifier.epage	669
dc.identifier.hkuros	210697
dc.identifier.hkuros	208907
dc.identifier.issn	0815-9319 2011 Impact Factor: 2.865 2011 SCImago Journal Rankings: 0.208
dc.identifier.issue	4
dc.identifier.pmid	22098452
dc.identifier.scopus	eid_2-s2.0-84858805271
dc.identifier.spage	662
dc.identifier.uri	http://hdl.handle.net/10722/163470
dc.identifier.volume	27
dc.language	eng
dc.publisher	Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
dc.publisher.place	Australia
dc.relation.ispartof	Journal of Gastroenterology and Hepatology
dc.relation.references	References in Scopus
dc.subject.mesh	Disease Progression
dc.subject.mesh	End Stage Liver Disease - etiology - therapy
dc.subject.mesh	Hepatitis B, Chronic - complications - virology
dc.subject.mesh	Humans
dc.subject.mesh	Liver Failure, Acute - etiology - therapy
dc.subject.mesh	Prognosis
dc.subject	Acute-On-Chronic Liver Failure
dc.subject	Hepatitis B
dc.subject	Hepatitis B Virus Dna
dc.subject	Liver Failure
dc.subject	Model Of End-Stage Liver Disease
dc.subject	Survival
dc.title	Acute-on-chronic liver failure in chronic hepatitis B
dc.type	Article

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Author Affiliations

The University of Hong Kong