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- Publisher Website: 10.1111/j.1440-1746.2011.06971.x
- Scopus: eid_2-s2.0-84858805271
- PMID: 22098452
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Article: Acute-on-chronic liver failure in chronic hepatitis B
Title | Acute-on-chronic liver failure in chronic hepatitis B |
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Authors | |
Keywords | Acute-On-Chronic Liver Failure Hepatitis B Hepatitis B Virus Dna Liver Failure Model Of End-Stage Liver Disease Survival |
Issue Date | 2012 |
Publisher | Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH |
Citation | Journal Of Gastroenterology And Hepatology, 2012, v. 27 n. 4, p. 662-669 How to Cite? |
Abstract | Acute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) is most commonly caused by acute severe exacerbation of CHB. The pathophysiology of ACLF in CHB is still poorly understood. Despite the identification of important predisposing factors and prognostic markers, ACLF in CHB remains a disease associated with high mortality. The majority of studies using nucleoside analog therapy did not show any significant improvement in survival, although larger prospective studies are needed. Liver transplantation is the definitive treatment for ACLF in CHB. The challenge ahead would be prognosticating cases with favorable or unfavorable outcomes in order to streamline patients for early transplantation or for medical therapy. © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/163470 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.179 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seto, WK | en_HK |
dc.contributor.author | Lai, CL | en_HK |
dc.contributor.author | Yuen, MF | en_HK |
dc.date.accessioned | 2012-09-05T05:31:45Z | - |
dc.date.available | 2012-09-05T05:31:45Z | - |
dc.date.issued | 2012 | en_HK |
dc.identifier.citation | Journal Of Gastroenterology And Hepatology, 2012, v. 27 n. 4, p. 662-669 | en_HK |
dc.identifier.issn | 0815-9319 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/163470 | - |
dc.description.abstract | Acute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) is most commonly caused by acute severe exacerbation of CHB. The pathophysiology of ACLF in CHB is still poorly understood. Despite the identification of important predisposing factors and prognostic markers, ACLF in CHB remains a disease associated with high mortality. The majority of studies using nucleoside analog therapy did not show any significant improvement in survival, although larger prospective studies are needed. Liver transplantation is the definitive treatment for ACLF in CHB. The challenge ahead would be prognosticating cases with favorable or unfavorable outcomes in order to streamline patients for early transplantation or for medical therapy. © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. | en_HK |
dc.language | eng | en_US |
dc.publisher | Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH | en_HK |
dc.relation.ispartof | Journal of Gastroenterology and Hepatology | en_HK |
dc.subject | Acute-On-Chronic Liver Failure | en_US |
dc.subject | Hepatitis B | en_US |
dc.subject | Hepatitis B Virus Dna | en_US |
dc.subject | Liver Failure | en_US |
dc.subject | Model Of End-Stage Liver Disease | en_US |
dc.subject | Survival | en_US |
dc.subject.mesh | Disease Progression | en_HK |
dc.subject.mesh | End Stage Liver Disease - etiology - therapy | en_HK |
dc.subject.mesh | Hepatitis B, Chronic - complications - virology | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Liver Failure, Acute - etiology - therapy | en_HK |
dc.subject.mesh | Prognosis | en_HK |
dc.title | Acute-on-chronic liver failure in chronic hepatitis B | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Seto, WK: wkseto2@hku.hk | en_HK |
dc.identifier.email | Lai, CL: hrmelcl@hku.hk | en_HK |
dc.identifier.email | Yuen, MF: mfyuen@hku.hk | en_HK |
dc.identifier.authority | Seto, WK=rp01659 | en_HK |
dc.identifier.authority | Lai, CL=rp00314 | en_HK |
dc.identifier.authority | Yuen, MF=rp00479 | en_HK |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1440-1746.2011.06971.x | en_HK |
dc.identifier.pmid | 22098452 | - |
dc.identifier.scopus | eid_2-s2.0-84858805271 | en_HK |
dc.identifier.hkuros | 210697 | - |
dc.identifier.hkuros | 208907 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84858805271&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 27 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 662 | en_HK |
dc.identifier.epage | 669 | en_HK |
dc.identifier.isi | WOS:000301924800008 | - |
dc.publisher.place | Australia | en_HK |
dc.identifier.scopusauthorid | Seto, WK=23390675900 | en_HK |
dc.identifier.scopusauthorid | Lai, CL=7403086396 | en_HK |
dc.identifier.scopusauthorid | Yuen, MF=7102031955 | en_HK |
dc.identifier.issnl | 0815-9319 | - |