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- PMID: 20659306
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Article: Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B
Title | Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B |
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Authors | |
Keywords | hepatitis B hepatocellular carcinoma liver stiffness |
Issue Date | 2011 |
Citation | Journal Of Viral Hepatitis, 2011, v. 18 n. 10, p. 738-744 How to Cite? |
Abstract | The prognostic value of liver stiffness measurements for chronic hepatitis B (CHB) is not known. The present study aimed to investigate the use of transient elastography in predicting hepatocellular carcinoma (HCC) development and mortality in patients with CHB. Five hundred and twenty-eight patients with HBeAg-negative CHB underwent liver stiffness measurements and were prospectively followed up every 3-6 months for a median length of 35 months. The patients were divided into those with liver stiffness <10 kPa (group 1) and ≥10 kPa (group 2). Of the 528 patients, 324 (61%) were men. The median age was 42 years. Compared with group 1, group 2 had a higher percentage of men, with higher median levels of age, liver biochemistry, and viral load. At the third year of follow-up, the cumulative incidence of HCC was higher in group 2 compared with group 1 (9%vs 0%, respectively, P < 0.001). The cumulative liver-related mortality was also higher in group 2 compared to group 1 (4%vs 0%, respectively, P < 0.001). After multivariate analysis, only liver stiffness measurement (LSM) was significantly associated with HCC development and mortality. There was also a higher cumulative incidence of hepatitis flares in group 2 compared to group 1 (46%vs 14%, respectively, P = 0.001) in patients with normal ALT, with higher LSM and AST being significantly associated with subsequent flares. In HBeAg-negative CHB patients, a liver stiffness measurement of ≥10 kPa was associated with a significantly increased risk of subsequent HCC development and mortality. © 2010 Blackwell Publishing Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/163400 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 1.078 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Fung, J | en_HK |
dc.contributor.author | Lai, CL | en_HK |
dc.contributor.author | Seto, WK | en_HK |
dc.contributor.author | Wong, DKH | en_HK |
dc.contributor.author | Yuen, MF | en_HK |
dc.date.accessioned | 2012-09-05T05:30:55Z | - |
dc.date.available | 2012-09-05T05:30:55Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Journal Of Viral Hepatitis, 2011, v. 18 n. 10, p. 738-744 | en_HK |
dc.identifier.issn | 1352-0504 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/163400 | - |
dc.description.abstract | The prognostic value of liver stiffness measurements for chronic hepatitis B (CHB) is not known. The present study aimed to investigate the use of transient elastography in predicting hepatocellular carcinoma (HCC) development and mortality in patients with CHB. Five hundred and twenty-eight patients with HBeAg-negative CHB underwent liver stiffness measurements and were prospectively followed up every 3-6 months for a median length of 35 months. The patients were divided into those with liver stiffness <10 kPa (group 1) and ≥10 kPa (group 2). Of the 528 patients, 324 (61%) were men. The median age was 42 years. Compared with group 1, group 2 had a higher percentage of men, with higher median levels of age, liver biochemistry, and viral load. At the third year of follow-up, the cumulative incidence of HCC was higher in group 2 compared with group 1 (9%vs 0%, respectively, P < 0.001). The cumulative liver-related mortality was also higher in group 2 compared to group 1 (4%vs 0%, respectively, P < 0.001). After multivariate analysis, only liver stiffness measurement (LSM) was significantly associated with HCC development and mortality. There was also a higher cumulative incidence of hepatitis flares in group 2 compared to group 1 (46%vs 14%, respectively, P = 0.001) in patients with normal ALT, with higher LSM and AST being significantly associated with subsequent flares. In HBeAg-negative CHB patients, a liver stiffness measurement of ≥10 kPa was associated with a significantly increased risk of subsequent HCC development and mortality. © 2010 Blackwell Publishing Ltd. | en_HK |
dc.language | eng | en_US |
dc.relation.ispartof | Journal of Viral Hepatitis | en_HK |
dc.subject | hepatitis B | en_HK |
dc.subject | hepatocellular carcinoma | en_HK |
dc.subject | liver stiffness | en_HK |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aged, 80 And Over | en_US |
dc.subject.mesh | Carcinoma, Hepatocellular - Diagnosis - Pathology | en_US |
dc.subject.mesh | Elasticity Imaging Techniques - Methods | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Hepatitis B E Antigens - Blood | en_US |
dc.subject.mesh | Hepatitis B, Chronic - Complications - Mortality - Pathology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Liver - Pathology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Prognosis | en_US |
dc.subject.mesh | Prospective Studies | en_US |
dc.subject.mesh | Survival Analysis | en_US |
dc.subject.mesh | Young Adult | en_US |
dc.title | Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAg-negative chronic hepatitis B | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Lai, CL: hrmelcl@hku.hk | en_HK |
dc.identifier.email | Seto, WK: wkseto2@hku.hk | en_HK |
dc.identifier.email | Wong, DKH: danywong@hku.hk | en_HK |
dc.identifier.email | Yuen, MF: mfyuen@hku.hk | en_HK |
dc.identifier.authority | Lai, CL=rp00314 | en_HK |
dc.identifier.authority | Seto, WK=rp01659 | en_HK |
dc.identifier.authority | Wong, DKH=rp00492 | en_HK |
dc.identifier.authority | Yuen, MF=rp00479 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1365-2893.2010.01355.x | en_HK |
dc.identifier.pmid | 20659306 | - |
dc.identifier.scopus | eid_2-s2.0-80052856495 | en_HK |
dc.identifier.hkuros | 211235 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80052856495&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 18 | en_HK |
dc.identifier.issue | 10 | en_HK |
dc.identifier.spage | 738 | en_HK |
dc.identifier.epage | 744 | en_HK |
dc.identifier.isi | WOS:000295091500035 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Fung, J=55032286400 | en_HK |
dc.identifier.scopusauthorid | Lai, CL=7403086396 | en_HK |
dc.identifier.scopusauthorid | Seto, WK=23390675900 | en_HK |
dc.identifier.scopusauthorid | Wong, DKH=7401535819 | en_HK |
dc.identifier.scopusauthorid | Yuen, MF=7102031955 | en_HK |
dc.identifier.issnl | 1352-0504 | - |