Article: A randomised controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnoea
| Title | A randomised controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnoea |
|---|---|
| Authors | Lam, JCM1 Lam, B1 Yao, TJ1 Lai, AYK1 Ooi, CG1 Tam, S2 Lam, KSL1 Ip, MSM1 2 |
| Keywords | Insulin sensitivity Nasal continuous positive airway pressure Obstructive sleep apnoea Randomised controlled trial |
| Issue Date | 2010 |
| Publisher | European Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com |
| Citation | European Respiratory Journal, 2010, v. 35 n. 1, p. 138-145 [How to Cite?] DOI: http://dx.doi.org/10.1183/09031936.00047709 |
| Abstract | The effects of treatment of obstructive sleep apnoea (OSA) on glucose metabolism have been investigated previously with conflicting results. This study evaluated the impact of nasal continuous positive airway pressure (nCPAP) treatment of OSA on insulin sensitivity. Males with moderate/severe OSA and no significant comorbidity were randomised to a therapeutic or sham nCPAP treatment group for 1 week and then reassessed. Those who received therapeutic nCPAP were further evaluated at 12 weeks. Insulin sensitivity (Kitt) was estimated by the short insulin tolerance test. Other evaluations included blood pressure, metabolic profile, urinary catecholamines and intra-abdominal fat. In total, 61 Chinese subjects were randomised. 31 subjects receiving therapeutic nCPAP showed an increase in Kitt (6.6±2.9 to 7.6±3.2 %·min -1; p50.017), while the 30 patients on sham CPAP had no significant change, and the changes in Kitt were different between the two groups (p=0.022). At 12 weeks, improvement in Kitt was seen in 20 subjects with BMI ≥25 kg·m -2 (median (interquartile range) 28.3 (26.6-31.5); p50.044), but not in the nine subjects with BMI<25 kg·m -2, or the entire group. The findings indicate that therapeutic nCPAP treatment of OSA for 1 week improved insulin sensitivity in nondiabetic males, and the improvement appeared to be maintained after 12 weeks of treatment in those with moderate obesity. Copyright©ERS Journals Ltd 2010. |
| ISSN | 0903-1936 2011 Impact Factor: 5.895 2011 SCImago Journal Rankings: 0.466 |
| DOI | http://dx.doi.org/10.1183/09031936.00047709 |
| References | References in Scopus |
| dc.contributor.author | Lam, JCM |
|---|---|
| dc.contributor.author | Lam, B |
| dc.contributor.author | Yao, TJ |
| dc.contributor.author | Lai, AYK |
| dc.contributor.author | Ooi, CG |
| dc.contributor.author | Tam, S |
| dc.contributor.author | Lam, KSL |
| dc.contributor.author | Ip, MSM |
| dc.date.accessioned | 2012-09-05T05:29:43Z |
| dc.date.available | 2012-09-05T05:29:43Z |
| dc.date.issued | 2010 |
| dc.description.abstract | The effects of treatment of obstructive sleep apnoea (OSA) on glucose metabolism have been investigated previously with conflicting results. This study evaluated the impact of nasal continuous positive airway pressure (nCPAP) treatment of OSA on insulin sensitivity. Males with moderate/severe OSA and no significant comorbidity were randomised to a therapeutic or sham nCPAP treatment group for 1 week and then reassessed. Those who received therapeutic nCPAP were further evaluated at 12 weeks. Insulin sensitivity (Kitt) was estimated by the short insulin tolerance test. Other evaluations included blood pressure, metabolic profile, urinary catecholamines and intra-abdominal fat. In total, 61 Chinese subjects were randomised. 31 subjects receiving therapeutic nCPAP showed an increase in Kitt (6.6±2.9 to 7.6±3.2 %·min -1; p50.017), while the 30 patients on sham CPAP had no significant change, and the changes in Kitt were different between the two groups (p=0.022). At 12 weeks, improvement in Kitt was seen in 20 subjects with BMI ≥25 kg·m -2 (median (interquartile range) 28.3 (26.6-31.5); p50.044), but not in the nine subjects with BMI<25 kg·m -2, or the entire group. The findings indicate that therapeutic nCPAP treatment of OSA for 1 week improved insulin sensitivity in nondiabetic males, and the improvement appeared to be maintained after 12 weeks of treatment in those with moderate obesity. Copyright©ERS Journals Ltd 2010. |
| dc.description.nature | Link_to_subscribed_fulltext |
| dc.identifier.citation | European Respiratory Journal, 2010, v. 35 n. 1, p. 138-145 [How to Cite?] DOI: http://dx.doi.org/10.1183/09031936.00047709 |
| dc.identifier.doi | http://dx.doi.org/10.1183/09031936.00047709 |
| dc.identifier.epage | 145 |
| dc.identifier.issn | 0903-1936 2011 Impact Factor: 5.895 2011 SCImago Journal Rankings: 0.466 |
| dc.identifier.issue | 1 |
| dc.identifier.pmid | 19608589 |
| dc.identifier.scopus | eid_2-s2.0-75149134456 |
| dc.identifier.spage | 138 |
| dc.identifier.uri | http://hdl.handle.net/10722/163291 |
| dc.identifier.volume | 35 |
| dc.language | eng |
| dc.publisher | European Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com |
| dc.publisher.place | Switzerland |
| dc.relation.ispartof | European Respiratory Journal |
| dc.relation.references | References in Scopus |
| dc.subject.mesh | Adult |
| dc.subject.mesh | Aged |
| dc.subject.mesh | Continuous Positive Airway Pressure |
| dc.subject.mesh | Double-Blind Method |
| dc.subject.mesh | Humans |
| dc.subject.mesh | Insulin - Metabolism |
| dc.subject.mesh | Male |
| dc.subject.mesh | Middle Aged |
| dc.subject.mesh | Sleep Apnea, Obstructive - Metabolism - Therapy |
| dc.subject.mesh | Young Adult |
| dc.subject | Insulin sensitivity |
| dc.subject | Nasal continuous positive airway pressure |
| dc.subject | Obstructive sleep apnoea |
| dc.subject | Randomised controlled trial |
| dc.title | A randomised controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnoea |
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- Queen Mary Hospital Hong Kong