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Article: A randomised controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnoea

TitleA randomised controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnoea
Authors
KeywordsInsulin sensitivity
Nasal continuous positive airway pressure
Obstructive sleep apnoea
Randomised controlled trial
Issue Date2010
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
European Respiratory Journal, 2010, v. 35 n. 1, p. 138-145 How to Cite?
AbstractThe effects of treatment of obstructive sleep apnoea (OSA) on glucose metabolism have been investigated previously with conflicting results. This study evaluated the impact of nasal continuous positive airway pressure (nCPAP) treatment of OSA on insulin sensitivity. Males with moderate/severe OSA and no significant comorbidity were randomised to a therapeutic or sham nCPAP treatment group for 1 week and then reassessed. Those who received therapeutic nCPAP were further evaluated at 12 weeks. Insulin sensitivity (Kitt) was estimated by the short insulin tolerance test. Other evaluations included blood pressure, metabolic profile, urinary catecholamines and intra-abdominal fat. In total, 61 Chinese subjects were randomised. 31 subjects receiving therapeutic nCPAP showed an increase in Kitt (6.6±2.9 to 7.6±3.2 %·min -1; p50.017), while the 30 patients on sham CPAP had no significant change, and the changes in Kitt were different between the two groups (p=0.022). At 12 weeks, improvement in Kitt was seen in 20 subjects with BMI ≥25 kg·m -2 (median (interquartile range) 28.3 (26.6-31.5); p50.044), but not in the nine subjects with BMI<25 kg·m -2, or the entire group. The findings indicate that therapeutic nCPAP treatment of OSA for 1 week improved insulin sensitivity in nondiabetic males, and the improvement appeared to be maintained after 12 weeks of treatment in those with moderate obesity. Copyright©ERS Journals Ltd 2010.
Persistent Identifierhttp://hdl.handle.net/10722/163291
ISSN
2015 Impact Factor: 8.332
2015 SCImago Journal Rankings: 3.204
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, JCMen_HK
dc.contributor.authorLam, Ben_HK
dc.contributor.authorYao, TJen_HK
dc.contributor.authorLai, AYKen_HK
dc.contributor.authorOoi, CGen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorIp, MSMen_HK
dc.date.accessioned2012-09-05T05:29:43Z-
dc.date.available2012-09-05T05:29:43Z-
dc.date.issued2010en_HK
dc.identifier.citationEuropean Respiratory Journal, 2010, v. 35 n. 1, p. 138-145en_HK
dc.identifier.issn0903-1936en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163291-
dc.description.abstractThe effects of treatment of obstructive sleep apnoea (OSA) on glucose metabolism have been investigated previously with conflicting results. This study evaluated the impact of nasal continuous positive airway pressure (nCPAP) treatment of OSA on insulin sensitivity. Males with moderate/severe OSA and no significant comorbidity were randomised to a therapeutic or sham nCPAP treatment group for 1 week and then reassessed. Those who received therapeutic nCPAP were further evaluated at 12 weeks. Insulin sensitivity (Kitt) was estimated by the short insulin tolerance test. Other evaluations included blood pressure, metabolic profile, urinary catecholamines and intra-abdominal fat. In total, 61 Chinese subjects were randomised. 31 subjects receiving therapeutic nCPAP showed an increase in Kitt (6.6±2.9 to 7.6±3.2 %·min -1; p50.017), while the 30 patients on sham CPAP had no significant change, and the changes in Kitt were different between the two groups (p=0.022). At 12 weeks, improvement in Kitt was seen in 20 subjects with BMI ≥25 kg·m -2 (median (interquartile range) 28.3 (26.6-31.5); p50.044), but not in the nine subjects with BMI<25 kg·m -2, or the entire group. The findings indicate that therapeutic nCPAP treatment of OSA for 1 week improved insulin sensitivity in nondiabetic males, and the improvement appeared to be maintained after 12 weeks of treatment in those with moderate obesity. Copyright©ERS Journals Ltd 2010.en_HK
dc.languageengen_US
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.comen_HK
dc.relation.ispartofEuropean Respiratory Journalen_HK
dc.subjectInsulin sensitivityen_HK
dc.subjectNasal continuous positive airway pressureen_HK
dc.subjectObstructive sleep apnoeaen_HK
dc.subjectRandomised controlled trialen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshContinuous Positive Airway Pressureen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSleep Apnea, Obstructive - Metabolism - Therapyen_US
dc.subject.meshYoung Adulten_US
dc.titleA randomised controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnoeaen_HK
dc.typeArticleen_HK
dc.identifier.emailYao, TJ: tjyao@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.emailIp, MSM: msmip@hku.hken_HK
dc.identifier.authorityYao, TJ=rp00284en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1183/09031936.00047709en_HK
dc.identifier.pmid19608589-
dc.identifier.scopuseid_2-s2.0-75149134456en_HK
dc.identifier.hkuros159900-
dc.identifier.hkuros182549-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-75149134456&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue1en_HK
dc.identifier.spage138en_HK
dc.identifier.epage145en_HK
dc.identifier.isiWOS:000274091300022-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLam, JCM=25923453500en_HK
dc.identifier.scopusauthoridLam, B=9246012800en_HK
dc.identifier.scopusauthoridYao, TJ=7401886444en_HK
dc.identifier.scopusauthoridLai, AYK=25641477800en_HK
dc.identifier.scopusauthoridOoi, CG=7007084909en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK

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