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Article: Protective roles of adiponectin in obesityrelated fatty liver diseases: Mechanisms and therapeutic implications | Adiponectina e seu papel na proteção contra a doença hepática gordurosa na obesidade: Mecanismos e implicações terapêuticas

TitleProtective roles of adiponectin in obesityrelated fatty liver diseases: Mechanisms and therapeutic implications | Adiponectina e seu papel na proteção contra a doença hepática gordurosa na obesidade: Mecanismos e implicações terapêuticas
Authors
KeywordsAdiponectin
Hepatic steatosis
Insulin resistance
NASH
Issue Date2009
Citation
Arquivos Brasileiros De Endocrinologia E Metabologia, 2009, v. 53 n. 2, p. 201-212 How to Cite?
AbstractAdiponectin is an insulin-sensitizing adipokine possessing multiple beneficial effects on obesity-related medical complications. This adipokine is secreted from adipocytes into the circulation as three oligomeric isoforms, including trimer, hexamer and the high molecular weight (HMW) oligomeric complex. Each oligomeric isoform of adiponectin possesses distinct biological properties and activates different signaling pathways in various target tissues. The hepato-protective activities have been demonstrated by many clinical and experimental studies. The decreased level of serum adiponectin represents an independent risk factor for nonalcoholic fatty liver disease (NAFLD) and liver dysfunctions in humans. In animals, elevation of circulating adiponectin by either pharmacological or genetic approaches leads to a significant alleviation of hepatomegaly, steatosis and necro-inflammation associated with various liver diseases. In adiponectin knockout mice, there is a pre-existing condition of hepatic steatosis and mitochondria dysfunction, which might contribute to the increased vulnerabilities of these mice to the secondary liver injuries induced by obesity and other conditions. This review aims to summarize recent advances on delination of the structural, molecular and cellular mechanisms underlying the hepato-protective properties of adiponectin.
Persistent Identifierhttp://hdl.handle.net/10722/163256
ISSN
2015 Impact Factor: 1.028
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Yen_HK
dc.contributor.authorMingyan, Zen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorXu, Aen_HK
dc.date.accessioned2012-09-05T05:29:13Z-
dc.date.available2012-09-05T05:29:13Z-
dc.date.issued2009en_HK
dc.identifier.citationArquivos Brasileiros De Endocrinologia E Metabologia, 2009, v. 53 n. 2, p. 201-212en_HK
dc.identifier.issn0004-2730en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163256-
dc.description.abstractAdiponectin is an insulin-sensitizing adipokine possessing multiple beneficial effects on obesity-related medical complications. This adipokine is secreted from adipocytes into the circulation as three oligomeric isoforms, including trimer, hexamer and the high molecular weight (HMW) oligomeric complex. Each oligomeric isoform of adiponectin possesses distinct biological properties and activates different signaling pathways in various target tissues. The hepato-protective activities have been demonstrated by many clinical and experimental studies. The decreased level of serum adiponectin represents an independent risk factor for nonalcoholic fatty liver disease (NAFLD) and liver dysfunctions in humans. In animals, elevation of circulating adiponectin by either pharmacological or genetic approaches leads to a significant alleviation of hepatomegaly, steatosis and necro-inflammation associated with various liver diseases. In adiponectin knockout mice, there is a pre-existing condition of hepatic steatosis and mitochondria dysfunction, which might contribute to the increased vulnerabilities of these mice to the secondary liver injuries induced by obesity and other conditions. This review aims to summarize recent advances on delination of the structural, molecular and cellular mechanisms underlying the hepato-protective properties of adiponectin.en_HK
dc.languageengen_US
dc.relation.ispartofArquivos Brasileiros de Endocrinologia e Metabologiaen_HK
dc.subjectAdiponectinen_HK
dc.subjectHepatic steatosisen_HK
dc.subjectInsulin resistanceen_HK
dc.subjectNASHen_HK
dc.subject.meshAdiponectin - Physiologyen_US
dc.subject.meshAdipose Tissue - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCardiovascular Diseases - Etiologyen_US
dc.subject.meshFatty Liver - Etiology - Physiopathology - Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin Resistance - Physiologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Knockouten_US
dc.subject.meshObesity - Complications - Metabolismen_US
dc.titleProtective roles of adiponectin in obesityrelated fatty liver diseases: Mechanisms and therapeutic implications | Adiponectina e seu papel na proteção contra a doença hepática gordurosa na obesidade: Mecanismos e implicações terapêuticasen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, Y: yuwanghk@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.authorityWang, Y=rp00239en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1590/S0004-27302009000200012-
dc.identifier.pmid19466213en_HK
dc.identifier.scopuseid_2-s2.0-67649411827en_HK
dc.identifier.hkuros156259-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67649411827&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue2en_HK
dc.identifier.spage201en_HK
dc.identifier.epage212en_HK
dc.identifier.isiWOS:000265288400012-
dc.identifier.scopusauthoridWang, Y=34973733700en_HK
dc.identifier.scopusauthoridMingyan, Z=36712192500en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK

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