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Article: Hepatitis B virus genotypes: natural history and implications for treatment.

TitleHepatitis B virus genotypes: natural history and implications for treatment.
Authors
Issue Date2007
PublisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/egh
Citation
Expert Review Of Gastroenterology & Hepatology, 2007, v. 1 n. 2, p. 321-328 How to Cite?
AbstractThere are eight different genotypes named A-H. Genotypes have distinct geographic distribution in different regions of the world. There exists a difference in the disease profile between different genotypes. Genotype A compared with D, and B compared with C have earlier hepatitis B e-antigen seroconversion and less severe liver disease. However, genotypes are closely linked with core promoter and precore mutations. This may have a confounding effect on the association of genotypes with disease progression. Patients with genotype A compared with D and B compared with C have a better treatment response to IFN-alpha. However, there are no differences in the treatment response and rate of emergence of drug-resistant hepatitis B virus between different genotypes to nucleoside/nucleotide analog therapy.
Persistent Identifierhttp://hdl.handle.net/10722/163233
ISSN
2015 SCImago Journal Rankings: 0.872

 

DC FieldValueLanguage
dc.contributor.authorYuen, MFen_US
dc.contributor.authorLai, CLen_US
dc.date.accessioned2012-09-05T05:29:00Z-
dc.date.available2012-09-05T05:29:00Z-
dc.date.issued2007en_US
dc.identifier.citationExpert Review Of Gastroenterology & Hepatology, 2007, v. 1 n. 2, p. 321-328en_US
dc.identifier.issn1747-4132en_US
dc.identifier.urihttp://hdl.handle.net/10722/163233-
dc.description.abstractThere are eight different genotypes named A-H. Genotypes have distinct geographic distribution in different regions of the world. There exists a difference in the disease profile between different genotypes. Genotype A compared with D, and B compared with C have earlier hepatitis B e-antigen seroconversion and less severe liver disease. However, genotypes are closely linked with core promoter and precore mutations. This may have a confounding effect on the association of genotypes with disease progression. Patients with genotype A compared with D and B compared with C have a better treatment response to IFN-alpha. However, there are no differences in the treatment response and rate of emergence of drug-resistant hepatitis B virus between different genotypes to nucleoside/nucleotide analog therapy.en_US
dc.languageengen_US
dc.publisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/egh-
dc.relation.ispartofExpert review of gastroenterology & hepatologyen_US
dc.subject.meshAntiviral Agents - Therapeutic Useen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHepatitis B - Drug Therapy - Virologyen_US
dc.subject.meshHepatitis B Virus - Drug Effects - Geneticsen_US
dc.subject.meshHumansen_US
dc.titleHepatitis B virus genotypes: natural history and implications for treatment.en_US
dc.typeArticleen_US
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityYuen, MF=rp00479en_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1586/17474124.1.2.321-
dc.identifier.pmid19072424-
dc.identifier.scopuseid_2-s2.0-61549105670en_US
dc.identifier.hkuros149093-
dc.identifier.volume1en_US
dc.identifier.issue2en_US
dc.identifier.spage321en_US
dc.identifier.epage328en_US
dc.publisher.placeUnited Kingdom-
dc.identifier.scopusauthoridYuen, MF=7102031955en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US

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