File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1586/17474124.1.2.321
- Scopus: eid_2-s2.0-61549105670
- PMID: 19072424
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Hepatitis B virus genotypes: natural history and implications for treatment.
Title | Hepatitis B virus genotypes: natural history and implications for treatment. |
---|---|
Authors | |
Issue Date | 2007 |
Publisher | Expert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/egh |
Citation | Expert Review Of Gastroenterology & Hepatology, 2007, v. 1 n. 2, p. 321-328 How to Cite? |
Abstract | There are eight different genotypes named A-H. Genotypes have distinct geographic distribution in different regions of the world. There exists a difference in the disease profile between different genotypes. Genotype A compared with D, and B compared with C have earlier hepatitis B e-antigen seroconversion and less severe liver disease. However, genotypes are closely linked with core promoter and precore mutations. This may have a confounding effect on the association of genotypes with disease progression. Patients with genotype A compared with D and B compared with C have a better treatment response to IFN-alpha. However, there are no differences in the treatment response and rate of emergence of drug-resistant hepatitis B virus between different genotypes to nucleoside/nucleotide analog therapy. |
Persistent Identifier | http://hdl.handle.net/10722/163233 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 1.090 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yuen, MF | en_US |
dc.contributor.author | Lai, CL | en_US |
dc.date.accessioned | 2012-09-05T05:29:00Z | - |
dc.date.available | 2012-09-05T05:29:00Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Expert Review Of Gastroenterology & Hepatology, 2007, v. 1 n. 2, p. 321-328 | en_US |
dc.identifier.issn | 1747-4132 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/163233 | - |
dc.description.abstract | There are eight different genotypes named A-H. Genotypes have distinct geographic distribution in different regions of the world. There exists a difference in the disease profile between different genotypes. Genotype A compared with D, and B compared with C have earlier hepatitis B e-antigen seroconversion and less severe liver disease. However, genotypes are closely linked with core promoter and precore mutations. This may have a confounding effect on the association of genotypes with disease progression. Patients with genotype A compared with D and B compared with C have a better treatment response to IFN-alpha. However, there are no differences in the treatment response and rate of emergence of drug-resistant hepatitis B virus between different genotypes to nucleoside/nucleotide analog therapy. | en_US |
dc.language | eng | en_US |
dc.publisher | Expert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/egh | - |
dc.relation.ispartof | Expert review of gastroenterology & hepatology | en_US |
dc.subject.mesh | Antiviral Agents - Therapeutic Use | en_US |
dc.subject.mesh | Genotype | en_US |
dc.subject.mesh | Hepatitis B - Drug Therapy - Virology | en_US |
dc.subject.mesh | Hepatitis B Virus - Drug Effects - Genetics | en_US |
dc.subject.mesh | Humans | en_US |
dc.title | Hepatitis B virus genotypes: natural history and implications for treatment. | en_US |
dc.type | Article | en_US |
dc.identifier.email | Yuen, MF:mfyuen@hkucc.hku.hk | en_US |
dc.identifier.email | Lai, CL:hrmelcl@hku.hk | en_US |
dc.identifier.authority | Yuen, MF=rp00479 | en_US |
dc.identifier.authority | Lai, CL=rp00314 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1586/17474124.1.2.321 | - |
dc.identifier.pmid | 19072424 | - |
dc.identifier.scopus | eid_2-s2.0-61549105670 | en_US |
dc.identifier.hkuros | 149093 | - |
dc.identifier.volume | 1 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 321 | en_US |
dc.identifier.epage | 328 | en_US |
dc.publisher.place | United Kingdom | - |
dc.identifier.scopusauthorid | Yuen, MF=7102031955 | en_US |
dc.identifier.scopusauthorid | Lai, CL=7403086396 | en_US |
dc.identifier.issnl | 1747-4124 | - |