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Article: Prevalence of albuminuria and cardiovascular risk profile in a referred cohort of patients with type 2 diabetes: An Asian perspective

TitlePrevalence of albuminuria and cardiovascular risk profile in a referred cohort of patients with type 2 diabetes: An Asian perspective
Authors
Issue Date2008
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/dia
Citation
Diabetes Technology And Therapeutics, 2008, v. 10 n. 5, p. 397-403 How to Cite?
AbstractBackground: Microalbuminuria (MA) is a risk marker for diabetic nephropathy and cardiovascular (CV) disease (CVD) in patients with diabetes. This study aimed to describe the prevalence of albuminuria, CV risk factors, and treatments for renal and CV protection in an Asian population with type 2 diabetes. Methods: This cross-sectional study conducted in eight Asian countries enrolled normotensive/hypertensive adults with type 2 diabetes without known proteinuria and/or non-diabetic kidney disease. Exclusion criteria were type 1 diabetes, menstruation, pregnancy, and acute fever. A single random urinary albumin/creatinine test was carried out in all patients. Results: Of 8,561 patients, 14% had diabetic retinopathy, and 17% and 21% had history of CV disease and smoking, respectively. Normoalbuminuria was seen in 44%, MA in 44%, and macroalbuminuria in 12%. Target glycosylated hemoglobin (HbA1c) (<7%) was reached in only 37% of 3,834 patients with available values. Diabetes was managed by diet alone in 6%, while others received oral hypoglycemic drugs and/or insulin. In total, 75% did not reach target blood pressure (BP) of ≤130/80 mm Hg. Antihypertensive drugs were prescribed to 52%, with the number of drugs increasing as the level of systolic BP increased. Drugs blocking the renin-angiotensin system were most commonly prescribed, followed by calcium channel blockers. Lipid-lowering drugs and anticoagulant/antiplatelet agents were used in about 30% and 25% of patients, respectively. Conclusions: Asian patients with type 2 diabetes had a high prevalence of MA and reduced kidney function. Furthermore, BP and HbA1c control was only achieved in a minority of patients. Aggressive risk management by administration of reno- and cardioprotective treatments is urgently needed. © 2008 Mary Ann Liebert, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/163196
ISSN
2015 Impact Factor: 2.198
2015 SCImago Journal Rankings: 1.144
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPan, CYen_US
dc.contributor.authorHo, LTen_US
dc.contributor.authorSoegondo, Sen_US
dc.contributor.authorProdjosudjadi, Wen_US
dc.contributor.authorSuwanwalaikorn, Sen_US
dc.contributor.authorLim, SCen_US
dc.contributor.authorChan, TMen_US
dc.contributor.authorChow, KWSen_US
dc.contributor.authorThoenes, Men_US
dc.contributor.authorChoi, DSen_US
dc.date.accessioned2012-09-05T05:28:37Z-
dc.date.available2012-09-05T05:28:37Z-
dc.date.issued2008en_US
dc.identifier.citationDiabetes Technology And Therapeutics, 2008, v. 10 n. 5, p. 397-403en_US
dc.identifier.issn1520-9156en_US
dc.identifier.urihttp://hdl.handle.net/10722/163196-
dc.description.abstractBackground: Microalbuminuria (MA) is a risk marker for diabetic nephropathy and cardiovascular (CV) disease (CVD) in patients with diabetes. This study aimed to describe the prevalence of albuminuria, CV risk factors, and treatments for renal and CV protection in an Asian population with type 2 diabetes. Methods: This cross-sectional study conducted in eight Asian countries enrolled normotensive/hypertensive adults with type 2 diabetes without known proteinuria and/or non-diabetic kidney disease. Exclusion criteria were type 1 diabetes, menstruation, pregnancy, and acute fever. A single random urinary albumin/creatinine test was carried out in all patients. Results: Of 8,561 patients, 14% had diabetic retinopathy, and 17% and 21% had history of CV disease and smoking, respectively. Normoalbuminuria was seen in 44%, MA in 44%, and macroalbuminuria in 12%. Target glycosylated hemoglobin (HbA1c) (<7%) was reached in only 37% of 3,834 patients with available values. Diabetes was managed by diet alone in 6%, while others received oral hypoglycemic drugs and/or insulin. In total, 75% did not reach target blood pressure (BP) of ≤130/80 mm Hg. Antihypertensive drugs were prescribed to 52%, with the number of drugs increasing as the level of systolic BP increased. Drugs blocking the renin-angiotensin system were most commonly prescribed, followed by calcium channel blockers. Lipid-lowering drugs and anticoagulant/antiplatelet agents were used in about 30% and 25% of patients, respectively. Conclusions: Asian patients with type 2 diabetes had a high prevalence of MA and reduced kidney function. Furthermore, BP and HbA1c control was only achieved in a minority of patients. Aggressive risk management by administration of reno- and cardioprotective treatments is urgently needed. © 2008 Mary Ann Liebert, Inc.en_US
dc.languageengen_US
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/diaen_US
dc.relation.ispartofDiabetes Technology and Therapeuticsen_US
dc.rightsThis is a copy of an article published in the Diabetes Technology & Therapeutics © 2008 copyright Mary Ann Liebert, Inc.; Diabetes Technology & Therapeutics is available online at: http://www.liebertonline.com-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAlbuminuria - Epidemiology - Ethnology - Physiopathology - Urineen_US
dc.subject.meshAsia - Epidemiologyen_US
dc.subject.meshBlood Pressure - Physiologyen_US
dc.subject.meshCardiovascular Diseases - Epidemiology - Ethnology - Physiopathology - Urineen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshCreatinine - Urineen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDiabetes Mellitus, Type 2 - Complications - Ethnology - Physiopathology - Urineen_US
dc.subject.meshDiabetic Nephropathies - Epidemiology - Ethnology - Physiopathology - Urineen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemoglobin A, Glycosylated - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshInternational Cooperationen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRisk Factorsen_US
dc.titlePrevalence of albuminuria and cardiovascular risk profile in a referred cohort of patients with type 2 diabetes: An Asian perspectiveen_US
dc.typeArticleen_US
dc.identifier.emailChan, TM:dtmchan@hku.hken_US
dc.identifier.authorityChan, TM=rp00394en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1089/dia.2007.0296en_US
dc.identifier.pmid18715217-
dc.identifier.scopuseid_2-s2.0-50049120570en_US
dc.identifier.hkuros162912-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-50049120570&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue5en_US
dc.identifier.spage397en_US
dc.identifier.epage403en_US
dc.identifier.isiWOS:000259177600010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridPan, CY=7403224625en_US
dc.identifier.scopusauthoridHo, LT=35195859600en_US
dc.identifier.scopusauthoridSoegondo, S=15056872600en_US
dc.identifier.scopusauthoridProdjosudjadi, W=6603254085en_US
dc.identifier.scopusauthoridSuwanwalaikorn, S=6506935197en_US
dc.identifier.scopusauthoridLim, SC=7404081443en_US
dc.identifier.scopusauthoridChan, TM=7402687700en_US
dc.identifier.scopusauthoridChow, KWS=24721202400en_US
dc.identifier.scopusauthoridThoenes, M=22636395600en_US
dc.identifier.scopusauthoridChoi, DS=7401643558en_US
dc.identifier.citeulike3702164-

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