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Article: Serum total and bioavailable testosterone levels, central obesity, and muscle strength changes with aging in healthy Chinese men

TitleSerum total and bioavailable testosterone levels, central obesity, and muscle strength changes with aging in healthy Chinese men
Authors
Issue Date2008
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGS
Citation
Journal Of The American Geriatrics Society, 2008, v. 56 n. 7, p. 1286-1291 How to Cite?
AbstractOBJECTIVES: To investigate the effects of the changes in serum bioavailable and total testosterone (TT) levels with aging on visceral body fat distribution and muscle strength in Chinese men. DESIGN: Cross-sectional study. SETTING: Ambulatory care. PARTICIPANTS: Four hundred seventy-five healthy ambulatory Chinese men (aged 18-89, body mass index (BMI) 16.4-40.0 kg/m 2). MEASUREMENTS: Morning serum total and bioavailable testosterone levels, waist circumference (WC), waist-hip ratio (WHR), and right handgrip strength. RESULTS: Mean serum TT levels fell mildly but significantly with aging (P=.02, linear trend; one-way analysis of variance (ANOVA)), whereas mean serum bioavailable testosterone (BT) levels fell greatly with aging (P<.001, linear trend, one-way ANOVA). The rates of decline in serum TT and BT levels were 0.2% and 1.14% per year, respectively. [Correction added after online publication 14-May-2008: BT levels have been corrected from 1.44% to 1.14%.] After adjustment for adiposity according to BMI, multiple linear regression analyses showed that age remained significantly related to serum TT and BT levels. Handgrip strength decreased with age (correlation coefficient (r)=-0.394, P<.001) and was greater with higher serum BT levels (r=0.239, P<.001) but not with higher TT levels. WHR, before and after adjustment for BMI, was inversely related to serum TT (r=-0.34 and -0.197 respectively, P<.001) and BT levels (r=-0.104, P<.05 and -0.161, P<.001, respectively). CONCLUSION: In Chinese men, serum BT levels decreased with aging and may contribute to central obesity and poorer muscle strength in aging men. © 2008, Copyright the Authors.
Persistent Identifierhttp://hdl.handle.net/10722/163190
ISSN
2015 Impact Factor: 3.842
2015 SCImago Journal Rankings: 2.236
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChu, LWen_US
dc.contributor.authorTam, Sen_US
dc.contributor.authorKung, AWCen_US
dc.contributor.authorLo, Sen_US
dc.contributor.authorFan, Sen_US
dc.contributor.authorWong, RLCen_US
dc.contributor.authorMorley, JEen_US
dc.contributor.authorLam, KSLen_US
dc.date.accessioned2012-09-05T05:28:34Z-
dc.date.available2012-09-05T05:28:34Z-
dc.date.issued2008en_US
dc.identifier.citationJournal Of The American Geriatrics Society, 2008, v. 56 n. 7, p. 1286-1291en_US
dc.identifier.issn0002-8614en_US
dc.identifier.urihttp://hdl.handle.net/10722/163190-
dc.description.abstractOBJECTIVES: To investigate the effects of the changes in serum bioavailable and total testosterone (TT) levels with aging on visceral body fat distribution and muscle strength in Chinese men. DESIGN: Cross-sectional study. SETTING: Ambulatory care. PARTICIPANTS: Four hundred seventy-five healthy ambulatory Chinese men (aged 18-89, body mass index (BMI) 16.4-40.0 kg/m 2). MEASUREMENTS: Morning serum total and bioavailable testosterone levels, waist circumference (WC), waist-hip ratio (WHR), and right handgrip strength. RESULTS: Mean serum TT levels fell mildly but significantly with aging (P=.02, linear trend; one-way analysis of variance (ANOVA)), whereas mean serum bioavailable testosterone (BT) levels fell greatly with aging (P<.001, linear trend, one-way ANOVA). The rates of decline in serum TT and BT levels were 0.2% and 1.14% per year, respectively. [Correction added after online publication 14-May-2008: BT levels have been corrected from 1.44% to 1.14%.] After adjustment for adiposity according to BMI, multiple linear regression analyses showed that age remained significantly related to serum TT and BT levels. Handgrip strength decreased with age (correlation coefficient (r)=-0.394, P<.001) and was greater with higher serum BT levels (r=0.239, P<.001) but not with higher TT levels. WHR, before and after adjustment for BMI, was inversely related to serum TT (r=-0.34 and -0.197 respectively, P<.001) and BT levels (r=-0.104, P<.05 and -0.161, P<.001, respectively). CONCLUSION: In Chinese men, serum BT levels decreased with aging and may contribute to central obesity and poorer muscle strength in aging men. © 2008, Copyright the Authors.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGSen_US
dc.relation.ispartofJournal of the American Geriatrics Societyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAging - Blood - Physiologyen_US
dc.subject.meshAndrogens - Blood - Metabolismen_US
dc.subject.meshBiological Availabilityen_US
dc.subject.meshBody Mass Indexen_US
dc.subject.meshChinaen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMuscle Strength - Physiologyen_US
dc.subject.meshObesity - Etiologyen_US
dc.subject.meshTestosterone - Blood - Metabolismen_US
dc.titleSerum total and bioavailable testosterone levels, central obesity, and muscle strength changes with aging in healthy Chinese menen_US
dc.typeArticleen_US
dc.identifier.emailKung, AWC:awckung@hku.hken_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.authorityKung, AWC=rp00368en_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1532-5415.2008.01746.xen_US
dc.identifier.pmid18482300-
dc.identifier.scopuseid_2-s2.0-48449087221en_US
dc.identifier.hkuros142081-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-48449087221&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume56en_US
dc.identifier.issue7en_US
dc.identifier.spage1286en_US
dc.identifier.epage1291en_US
dc.identifier.isiWOS:000258073800018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChu, LW=7202236665en_US
dc.identifier.scopusauthoridTam, S=7202037323en_US
dc.identifier.scopusauthoridKung, AWC=7102322339en_US
dc.identifier.scopusauthoridLo, S=8718876900en_US
dc.identifier.scopusauthoridFan, S=11639038000en_US
dc.identifier.scopusauthoridWong, RLC=37062742700en_US
dc.identifier.scopusauthoridMorley, JE=7403144221en_US
dc.identifier.scopusauthoridLam, KSL=8082870600en_US
dc.identifier.citeulike3076401-

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