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Article: Antibodies to mannose binding lectin in patients with systemic lupus erythematosus

TitleAntibodies to mannose binding lectin in patients with systemic lupus erythematosus
Authors
KeywordsAnti-MBL antibodies
ELISA
Immune-complex
MBL deficiency
Issue Date2004
PublisherSage Publications Ltd. The Journal's web site is located at http://lup.sagepub.com
Citation
Lupus, 2004, v. 13 n. 7, p. 522-528 How to Cite?
AbstractDeficiency of mannose binding lectin (MBL), a C-type lectin with structural similarities to C1q, has been shown to predispose to the development of systemic lupus erythematosus (SLE). Some patients have low serum MBL levels which cannot be explained by either structural gene mutations or promoter polymorphisms. The objective of this study was to detect the presence of autoantibodies against MBL and to evaluate their relationship to serum MBL levels. Anti-MBL antibodies of IgM and IgG classes from consecutive SLE patients (n = 135) and healthy subjects (n = 50) were measured by an in-house ELISA. Using the 90th percentile of controls as a cutoff, more SLE patients [23.7% (32/135)] were found to have IgG anti-MBL antibodies than normal controls [10.0% (5/50)] (P = 0.04). The same trend was observed when ethnicity was taken into account by analysing Caucasians alone (n = 90). IgM anti-MBL antibodies were only found in two SLE patients (2/22, 9.1%) who had no concomitant IgG anti-MBL antibodies. Serum levels of IgG anti-MBL antibodies were found to correlate with serum MBL levels (r = 0.55, P = 0.049). However, the levels of anti-MBL antibodies did not correlate with overall disease activity. Thus the production of anti-MBL antibodies is likely to be a specific antigen-driven process. Its role in lupus pathogenesis remains to be elucidated.
Persistent Identifierhttp://hdl.handle.net/10722/163146
ISSN
2015 Impact Factor: 2.118
2015 SCImago Journal Rankings: 0.878
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMok, MYen_HK
dc.contributor.authorJack, DLen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorFong, DYTen_HK
dc.contributor.authorTurner, MWen_HK
dc.contributor.authorIsenberg, DAen_HK
dc.contributor.authorLydyard, PMen_HK
dc.date.accessioned2012-09-05T05:28:09Z-
dc.date.available2012-09-05T05:28:09Z-
dc.date.issued2004en_HK
dc.identifier.citationLupus, 2004, v. 13 n. 7, p. 522-528en_HK
dc.identifier.issn0961-2033en_HK
dc.identifier.urihttp://hdl.handle.net/10722/163146-
dc.description.abstractDeficiency of mannose binding lectin (MBL), a C-type lectin with structural similarities to C1q, has been shown to predispose to the development of systemic lupus erythematosus (SLE). Some patients have low serum MBL levels which cannot be explained by either structural gene mutations or promoter polymorphisms. The objective of this study was to detect the presence of autoantibodies against MBL and to evaluate their relationship to serum MBL levels. Anti-MBL antibodies of IgM and IgG classes from consecutive SLE patients (n = 135) and healthy subjects (n = 50) were measured by an in-house ELISA. Using the 90th percentile of controls as a cutoff, more SLE patients [23.7% (32/135)] were found to have IgG anti-MBL antibodies than normal controls [10.0% (5/50)] (P = 0.04). The same trend was observed when ethnicity was taken into account by analysing Caucasians alone (n = 90). IgM anti-MBL antibodies were only found in two SLE patients (2/22, 9.1%) who had no concomitant IgG anti-MBL antibodies. Serum levels of IgG anti-MBL antibodies were found to correlate with serum MBL levels (r = 0.55, P = 0.049). However, the levels of anti-MBL antibodies did not correlate with overall disease activity. Thus the production of anti-MBL antibodies is likely to be a specific antigen-driven process. Its role in lupus pathogenesis remains to be elucidated.en_HK
dc.languageengen_US
dc.publisherSage Publications Ltd. The Journal's web site is located at http://lup.sagepub.comen_HK
dc.relation.ispartofLupusen_HK
dc.rightsLupus. Copyright © Sage Publications Ltd.-
dc.subjectAnti-MBL antibodiesen_HK
dc.subjectELISAen_HK
dc.subjectImmune-complexen_HK
dc.subjectMBL deficiencyen_HK
dc.subject.meshAdulten_US
dc.subject.meshAutoantibodies - Blooden_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin G - Blooden_US
dc.subject.meshImmunoglobulin M - Blooden_US
dc.subject.meshLupus Erythematosus, Systemic - Blood - Immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMannose-Binding Lectins - Deficiency - Immunologyen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRegression Analysisen_US
dc.titleAntibodies to mannose binding lectin in patients with systemic lupus erythematosusen_HK
dc.typeArticleen_HK
dc.identifier.emailMok, MY: temy@hkucc.hku.hken_HK
dc.identifier.emailLau, CS: cslau@hku.hken_HK
dc.identifier.emailFong, DYT: dytfong@hku.hken_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.identifier.authorityFong, DYT=rp00253en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1191/0961203303lu1055oaen_HK
dc.identifier.pmid15352424-
dc.identifier.scopuseid_2-s2.0-4043056414en_HK
dc.identifier.hkuros92220-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4043056414&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue7en_HK
dc.identifier.spage522en_HK
dc.identifier.epage528en_HK
dc.identifier.isiWOS:000223255600008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridJack, DL=7102511491en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridFong, DYT=35261710300en_HK
dc.identifier.scopusauthoridTurner, MW=7403215582en_HK
dc.identifier.scopusauthoridIsenberg, DA=36051280800en_HK
dc.identifier.scopusauthoridLydyard, PM=7006782855en_HK

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