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Article: Anti-DNA antibodies in the pathogenesis of lupus nephritis - The emerging mechanisms

TitleAnti-DNA antibodies in the pathogenesis of lupus nephritis - The emerging mechanisms
Authors
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/autrev
Citation
Autoimmunity Reviews, 2008, v. 7 n. 4, p. 317-321 How to Cite?
AbstractLupus nephritis is a major organ manifestation of systemic lupus erythematosus (SLE) that could lead to acute or chronic renal failure. Active lupus is characterized serologically by high titres of anti-DNA antibodies. Compelling evidence suggests that anti-DNA antibodies, in addition to being an important diagnostic marker, are also actively involved in the pathogenesis of lupus nephritis through their ability to bind to cell surface antigens or components of the glomerular basement membrane either directly (cross-reactivity) or indirectly (via chromatin material). Accumulating data indicate that following cellular binding anti-DNA antibodies can be internalized, and the process is associated with induction of inflammatory cascades and alteration of cellular functions such as proliferation, viability, or morphological changes. Circulating anti-DNA antibodies represent a heterogeneous population. The nephritogenic property of sub-sets of anti-DNA antibodies stems in part from their ability to recognize intrinsic glomerular or tubular structures. However, recent data have shown that lupus nephritis could develop in some animal models in the absence of anti-DNA antibodies, suggesting that nephritogenicity is not an exclusive or unique property of these antibodies. This review will discuss the mechanisms through which anti-DNA antibodies mediate tissue injury and initiate inflammatory processes in the kidney. © 2007 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/163141
ISSN
2015 Impact Factor: 8.49
2015 SCImago Journal Rankings: 2.260
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYung, Sen_US
dc.contributor.authorChan, TMen_US
dc.date.accessioned2012-09-05T05:28:04Z-
dc.date.available2012-09-05T05:28:04Z-
dc.date.issued2008en_US
dc.identifier.citationAutoimmunity Reviews, 2008, v. 7 n. 4, p. 317-321en_US
dc.identifier.issn1568-9972en_US
dc.identifier.urihttp://hdl.handle.net/10722/163141-
dc.description.abstractLupus nephritis is a major organ manifestation of systemic lupus erythematosus (SLE) that could lead to acute or chronic renal failure. Active lupus is characterized serologically by high titres of anti-DNA antibodies. Compelling evidence suggests that anti-DNA antibodies, in addition to being an important diagnostic marker, are also actively involved in the pathogenesis of lupus nephritis through their ability to bind to cell surface antigens or components of the glomerular basement membrane either directly (cross-reactivity) or indirectly (via chromatin material). Accumulating data indicate that following cellular binding anti-DNA antibodies can be internalized, and the process is associated with induction of inflammatory cascades and alteration of cellular functions such as proliferation, viability, or morphological changes. Circulating anti-DNA antibodies represent a heterogeneous population. The nephritogenic property of sub-sets of anti-DNA antibodies stems in part from their ability to recognize intrinsic glomerular or tubular structures. However, recent data have shown that lupus nephritis could develop in some animal models in the absence of anti-DNA antibodies, suggesting that nephritogenicity is not an exclusive or unique property of these antibodies. This review will discuss the mechanisms through which anti-DNA antibodies mediate tissue injury and initiate inflammatory processes in the kidney. © 2007 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/autreven_US
dc.relation.ispartofAutoimmunity Reviewsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Antinuclear - Immunologyen_US
dc.subject.meshAntigen-Antibody Complexen_US
dc.subject.meshGlomerular Basement Membrane - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney - Immunology - Physiopathologyen_US
dc.subject.meshLupus Nephritis - Immunology - Physiopathologyen_US
dc.subject.meshRenal Insufficiency - Immunology - Physiopathologyen_US
dc.titleAnti-DNA antibodies in the pathogenesis of lupus nephritis - The emerging mechanismsen_US
dc.typeArticleen_US
dc.identifier.emailYung, S:ssyyung@hku.hken_US
dc.identifier.emailChan, TM:dtmchan@hku.hken_US
dc.identifier.authorityYung, S=rp00455en_US
dc.identifier.authorityChan, TM=rp00394en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.autrev.2007.12.001en_US
dc.identifier.pmid18295737-
dc.identifier.scopuseid_2-s2.0-39549111438en_US
dc.identifier.hkuros142660-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-39549111438&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume7en_US
dc.identifier.issue4en_US
dc.identifier.spage317en_US
dc.identifier.epage321en_US
dc.identifier.isiWOS:000254209100010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYung, S=22636568800en_US
dc.identifier.scopusauthoridChan, TM=7402687700en_US

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