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Article: Hyaluronan - Regulator and initiator of peritoneal inflammation and remodeling

TitleHyaluronan - Regulator and initiator of peritoneal inflammation and remodeling
Authors
Issue Date2007
PublisherWichtig Editore srl. The Journal's web site is located at http://www.artificial-organs.com
Citation
International Journal Of Artificial Organs, 2007, v. 30 n. 6, p. 477-483 How to Cite?
AbstractAlthough previously described as an inert space filler, there is now compelling evidence to underscore the importance of hyaluronan in physiologic and pathologic processes. Despite its simple structure, hyaluronan plays essential roles in embryonic development, phenotypic changes, proliferation, wound healing, inflammation and angiogenesis. Hyaluronan is a major component of the glycocalyx that forms a protective barrier around mesothelial cells, and bestows upon the peritoneal membrane a slippery non-adhesive surface preventing abrasion, infection and tumor dissemination. Hyaluronan is associated with mesothelial-to-mesenchymal transdifferentiation, recruitment of leukocytes to sites of inflammation, and mediates the reparative process after tissue injury by initiating increased synthesis of growth factors. Serum and dialysate levels of hyaluronan are increased in patients maintained on peritoneal dialysis (PD), of which the levels are further increased during episodes of peritonitis. The level of hyaluronan in PD effluents is often used as a surrogate marker for peritoneal inflammation and can predict patient survival. This review will describe the multifacet-ed roles of hyaluronan in the peritoneum and how these roles are modulated during PD. © Wichtig Editore, 2007.
Persistent Identifierhttp://hdl.handle.net/10722/163099
ISSN
2015 Impact Factor: 1.005
2015 SCImago Journal Rankings: 0.585
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYung, Sen_US
dc.contributor.authorChan, TMen_US
dc.date.accessioned2012-09-05T05:27:35Z-
dc.date.available2012-09-05T05:27:35Z-
dc.date.issued2007en_US
dc.identifier.citationInternational Journal Of Artificial Organs, 2007, v. 30 n. 6, p. 477-483en_US
dc.identifier.issn0391-3988en_US
dc.identifier.urihttp://hdl.handle.net/10722/163099-
dc.description.abstractAlthough previously described as an inert space filler, there is now compelling evidence to underscore the importance of hyaluronan in physiologic and pathologic processes. Despite its simple structure, hyaluronan plays essential roles in embryonic development, phenotypic changes, proliferation, wound healing, inflammation and angiogenesis. Hyaluronan is a major component of the glycocalyx that forms a protective barrier around mesothelial cells, and bestows upon the peritoneal membrane a slippery non-adhesive surface preventing abrasion, infection and tumor dissemination. Hyaluronan is associated with mesothelial-to-mesenchymal transdifferentiation, recruitment of leukocytes to sites of inflammation, and mediates the reparative process after tissue injury by initiating increased synthesis of growth factors. Serum and dialysate levels of hyaluronan are increased in patients maintained on peritoneal dialysis (PD), of which the levels are further increased during episodes of peritonitis. The level of hyaluronan in PD effluents is often used as a surrogate marker for peritoneal inflammation and can predict patient survival. This review will describe the multifacet-ed roles of hyaluronan in the peritoneum and how these roles are modulated during PD. © Wichtig Editore, 2007.en_US
dc.languageengen_US
dc.publisherWichtig Editore srl. The Journal's web site is located at http://www.artificial-organs.comen_US
dc.relation.ispartofInternational Journal of Artificial Organsen_US
dc.subject.meshDialysis Solutionsen_US
dc.subject.meshEpithelial Cells - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshHyaluronic Acid - Biosynthesis - Blood - Metabolismen_US
dc.subject.meshInflammation - Physiopathologyen_US
dc.subject.meshPeritoneal Dialysisen_US
dc.subject.meshPeritoneum - Metabolism - Physiopathologyen_US
dc.subject.meshPeritonitis - Blood - Etiology - Physiopathologyen_US
dc.titleHyaluronan - Regulator and initiator of peritoneal inflammation and remodelingen_US
dc.typeArticleen_US
dc.identifier.emailYung, S:ssyyung@hku.hken_US
dc.identifier.emailChan, TM:dtmchan@hku.hken_US
dc.identifier.authorityYung, S=rp00455en_US
dc.identifier.authorityChan, TM=rp00394en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid17628848-
dc.identifier.scopuseid_2-s2.0-34547872802en_US
dc.identifier.hkuros130433-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547872802&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume30en_US
dc.identifier.issue6en_US
dc.identifier.spage477en_US
dc.identifier.epage483en_US
dc.identifier.isiWOS:000248541600003-
dc.publisher.placeItalyen_US
dc.identifier.scopusauthoridYung, S=22636568800en_US
dc.identifier.scopusauthoridChan, TM=7402687700en_US

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