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Article: Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion

TitleDifference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion
Authors
Issue Date2007
Citation
Journal of Viral Hepatitis, 2007, v. 14 n. 4, p. 269-275 How to Cite?
AbstractThe underlying mechanisms for earlier hepatitis B e antigen (HBeAg) seroconversion in patients with chronic hepatitis B virus (HBV) genotype B when compared with genotype C are unknown. We aimed to determine whether there were any differences in the T helper (Th) responses during hepatitis flares in HBeAg-positive patients with genotypes B and C. Proliferative response measured by 3H-thymidine uptake and Th responses measured by Enzyme-Linked Immunosorbent Spot assays for interleukin (IL)-2, interferon-gamma (IFN-γ), IL-4, IL-5 and IL-10 were performed in 10 patients with genotype B and 10 with genotype C with hepatitis flares. HBV genotypes, core promoter, precore mutations, sequence of HBV core region and HBV DNA levels were determined. There was no difference in the HBV DNA levels during hepatitis flares between patients with genotypes B and C. Patients with genotype B had a significantly higher number of IFN-γ producing cells [with hepatitis B core antigen (HBcAg) stimulation] and lower number of IL-10 producing cells (with HBcAg and HBeAg stimulation) compared with patients with genotype C (P = 0.011, =0.043, <0.001 respectively). There was a trend (P = 0.058) that patients with genotype B had a higher cumulative rate of HBeAg seroconversion. Patients with precore mutants also had a significantly higher number of IFN-γ producing cells (with HBcAg stimulation) and lower number of IL-10 producing cells (with HBeAg stimulation) compared to patients without precore mutant (P = 0.038, =0.016 respectively). HBV genotype B induces a greater Th1 and lesser Th2 response than genotype C. This provides immunologic evidence for the higher chance of HBeAg seroconversion in patients with genotype B. © 2007 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/163069
ISSN
2015 Impact Factor: 4.179
2015 SCImago Journal Rankings: 1.815
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, MFen_US
dc.contributor.authorWong, DKHen_US
dc.contributor.authorZheng, Ben_US
dc.contributor.authorChan, CCSen_US
dc.contributor.authorYuen, JCHen_US
dc.contributor.authorWong, BCYen_US
dc.contributor.authorLai, CLen_US
dc.date.accessioned2012-09-05T05:27:11Z-
dc.date.available2012-09-05T05:27:11Z-
dc.date.issued2007en_US
dc.identifier.citationJournal of Viral Hepatitis, 2007, v. 14 n. 4, p. 269-275en_US
dc.identifier.issn1352-0504en_US
dc.identifier.urihttp://hdl.handle.net/10722/163069-
dc.description.abstractThe underlying mechanisms for earlier hepatitis B e antigen (HBeAg) seroconversion in patients with chronic hepatitis B virus (HBV) genotype B when compared with genotype C are unknown. We aimed to determine whether there were any differences in the T helper (Th) responses during hepatitis flares in HBeAg-positive patients with genotypes B and C. Proliferative response measured by 3H-thymidine uptake and Th responses measured by Enzyme-Linked Immunosorbent Spot assays for interleukin (IL)-2, interferon-gamma (IFN-γ), IL-4, IL-5 and IL-10 were performed in 10 patients with genotype B and 10 with genotype C with hepatitis flares. HBV genotypes, core promoter, precore mutations, sequence of HBV core region and HBV DNA levels were determined. There was no difference in the HBV DNA levels during hepatitis flares between patients with genotypes B and C. Patients with genotype B had a significantly higher number of IFN-γ producing cells [with hepatitis B core antigen (HBcAg) stimulation] and lower number of IL-10 producing cells (with HBcAg and HBeAg stimulation) compared with patients with genotype C (P = 0.011, =0.043, <0.001 respectively). There was a trend (P = 0.058) that patients with genotype B had a higher cumulative rate of HBeAg seroconversion. Patients with precore mutants also had a significantly higher number of IFN-γ producing cells (with HBcAg stimulation) and lower number of IL-10 producing cells (with HBeAg stimulation) compared to patients without precore mutant (P = 0.038, =0.016 respectively). HBV genotype B induces a greater Th1 and lesser Th2 response than genotype C. This provides immunologic evidence for the higher chance of HBeAg seroconversion in patients with genotype B. © 2007 The Authors.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Viral Hepatitisen_US
dc.rightsJournal of Viral Hepatitis. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHepatitis B Core Antigens - Genetics - Immunologyen_US
dc.subject.meshHepatitis B E Antigens - Biosynthesis - Genetics - Immunologyen_US
dc.subject.meshHepatitis B Virus - Genetics - Immunologyen_US
dc.subject.meshHepatitis B, Chronic - Genetics - Immunology - Virologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInterferon-Gamma - Biosynthesis - Immunologyen_US
dc.subject.meshInterleukin-10 - Immunologyen_US
dc.subject.meshInterleukin-2 - Immunologyen_US
dc.subject.meshInterleukin-4 - Immunologyen_US
dc.subject.meshInterleukin-5 - Immunologyen_US
dc.subject.meshLymphocyte Activationen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMutationen_US
dc.subject.meshPromoter Regions, Geneticen_US
dc.subject.meshTh1 Cells - Immunologyen_US
dc.subject.meshTh2 Cells - Immunologyen_US
dc.titleDifference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversionen_US
dc.typeArticleen_US
dc.identifier.emailYuen, MF: mfyuen@hkucc.hku.hken_US
dc.identifier.emailWong, DKH: danywong@hku.hken_US
dc.identifier.emailZheng, B: bzheng@hkucc.hku.hken_US
dc.identifier.emailYuen, JCH: jchyuen@HKUCC.hku.hken_US
dc.identifier.emailWong, BCY: bcywong@hku.hken_US
dc.identifier.emailLai, CL: hrmelcl@hku.hk-
dc.identifier.authorityYuen, MF=rp00479en_US
dc.identifier.authorityWong, DKH=rp00492en_US
dc.identifier.authorityZheng, B=rp00353en_US
dc.identifier.authorityWong, BCY=rp00429en_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2893.2006.00799.xen_US
dc.identifier.pmid17381719-
dc.identifier.scopuseid_2-s2.0-33947432473en_US
dc.identifier.hkuros130666-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33947432473&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue4en_US
dc.identifier.spage269en_US
dc.identifier.epage275en_US
dc.identifier.isiWOS:000245983200007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYuen, MF=7102031955en_US
dc.identifier.scopusauthoridWong, DKH=7401535819en_US
dc.identifier.scopusauthoridZheng, BJ=7201780588en_US
dc.identifier.scopusauthoridChan, CCS=16021156900en_US
dc.identifier.scopusauthoridYuen, JCH=7102620480en_US
dc.identifier.scopusauthoridWong, BCY=7402023340en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.citeulike1185046-

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