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Article: Peritoneal mesothelial cell culture and biology

TitlePeritoneal mesothelial cell culture and biology
Authors
Issue Date2006
PublisherMultimed, Inc. The Journal's web site is located at http://pdiconnect.com
Citation
Peritoneal Dialysis International, 2006, v. 26 n. 2, p. 162-173 How to Cite?
Abstract
The peritoneal mesothelium is composed of an extensive monolayer of mesothelial cells that lines the body's serous cavity and internal organs and was previously thought to act principally as a protective nonadhesive lubricating surface to facilitate intracoelomic movement. With the introduction of peritoneal dialysis over three decades ago, there has been much interest in the cell biology of peritoneal mesothelial cells. Independent studies have highlighted specific properties of the peritoneal mesothelial cell, including antigen presentation, regenerative properties, clearance of fibrin; synthesis of cytokines, growth factors, and matrix proteins; and secretion of lubricants to protect the tissue from abrasion, adhesion, infection, and tumor dissemination. It is now evident that the mesothelium is not merely a passive membrane but, rather, a dynamic membrane that contributes substantially to the structural, functional, and homeostatic properties of the pentoneum. Since peritoneal mesothelial cells in culture possess immunohistochemical markers identical to mesothelial stem cells, the culture of mesothelial cells offers researchers an essential tool to assess their morphologic, structural, and functional properties. This review will discuss current procedures to isolate peritoneal mesothelial cells from human omental specimens, animal sources, and spent dialysate. Furthermore, the functional and morphologic properties of mesothelial cells are discussed, together with the potential use of mesothelial cell culture in research and clinical applications. Copyright © 2006 International Society for Peritoneal Dialysis.
Persistent Identifierhttp://hdl.handle.net/10722/163010
ISSN
2013 Impact Factor: 2.199
2013 SCImago Journal Rankings: 1.189
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYung, Sen_US
dc.contributor.authorLi, FKen_US
dc.contributor.authorChan, TMen_US
dc.date.accessioned2012-09-05T05:26:30Z-
dc.date.available2012-09-05T05:26:30Z-
dc.date.issued2006en_US
dc.identifier.citationPeritoneal Dialysis International, 2006, v. 26 n. 2, p. 162-173en_US
dc.identifier.issn0896-8608en_US
dc.identifier.urihttp://hdl.handle.net/10722/163010-
dc.description.abstractThe peritoneal mesothelium is composed of an extensive monolayer of mesothelial cells that lines the body's serous cavity and internal organs and was previously thought to act principally as a protective nonadhesive lubricating surface to facilitate intracoelomic movement. With the introduction of peritoneal dialysis over three decades ago, there has been much interest in the cell biology of peritoneal mesothelial cells. Independent studies have highlighted specific properties of the peritoneal mesothelial cell, including antigen presentation, regenerative properties, clearance of fibrin; synthesis of cytokines, growth factors, and matrix proteins; and secretion of lubricants to protect the tissue from abrasion, adhesion, infection, and tumor dissemination. It is now evident that the mesothelium is not merely a passive membrane but, rather, a dynamic membrane that contributes substantially to the structural, functional, and homeostatic properties of the pentoneum. Since peritoneal mesothelial cells in culture possess immunohistochemical markers identical to mesothelial stem cells, the culture of mesothelial cells offers researchers an essential tool to assess their morphologic, structural, and functional properties. This review will discuss current procedures to isolate peritoneal mesothelial cells from human omental specimens, animal sources, and spent dialysate. Furthermore, the functional and morphologic properties of mesothelial cells are discussed, together with the potential use of mesothelial cell culture in research and clinical applications. Copyright © 2006 International Society for Peritoneal Dialysis.en_US
dc.languageengen_US
dc.publisherMultimed, Inc. The Journal's web site is located at http://pdiconnect.comen_US
dc.relation.ispartofPeritoneal Dialysis Internationalen_US
dc.subject.meshCell Culture Techniques - Methodsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshEpithelial Cells - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshPeritoneum - Cytologyen_US
dc.titlePeritoneal mesothelial cell culture and biologyen_US
dc.typeArticleen_US
dc.identifier.emailYung, S:ssyyung@hku.hken_US
dc.identifier.emailChan, TM:dtmchan@hku.hken_US
dc.identifier.authorityYung, S=rp00455en_US
dc.identifier.authorityChan, TM=rp00394en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16623418en_US
dc.identifier.scopuseid_2-s2.0-33747135979en_US
dc.identifier.hkuros117899-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747135979&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume26en_US
dc.identifier.issue2en_US
dc.identifier.spage162en_US
dc.identifier.epage173en_US
dc.identifier.isiWOS:000237003600007-
dc.publisher.placeCanadaen_US
dc.identifier.scopusauthoridYung, S=22636568800en_US
dc.identifier.scopusauthoridLi, FK=8219093900en_US
dc.identifier.scopusauthoridChan, TM=7402687700en_US

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