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Article: Idiopathic inflammatory demyelinating disorders after acute transverse myelitis

TitleIdiopathic inflammatory demyelinating disorders after acute transverse myelitis
Authors
Issue Date2006
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ENE
Citation
European Journal Of Neurology, 2006, v. 13 n. 8, p. 862-868 How to Cite?
AbstractAcute transverse myelitis (ATM) is commonly para-infectious. Recurrent ATM occurs in connective tissue diseases (CTD), infective myelitis and idiopathic inflammatory demyelinating disorders (IIDD) including multiple sclerosis (MS) and neuromyelitis optica (NMO). Previous studies might include NMO and idiopathic recurrent transverse myelitis (IRTM) as MS. The aim was to study the outcome of patients after a first attack of idiopathic ATM. Idiopathic ATM patients over a 6-year period were retrospectively studied. Known causes of myelopathy were excluded. Among 32 patients studied, 20 (63%) had single ATM attack upon follow up for 39-93 months, three developed recurrent ATM related to CTD (two systemic lupus erythematosus and one anti-Ro antibody positive) and nine (28.1%) developed recurrent neuroinflammation compatible with IIDD. Among IIDD patients, three had NMO, two restricted variant of NMO, three IRTM and one classical MS. NMO, its variant and IRTM had mean spinal MRI abnormality of 3.7, 2.1 and 3.9 vertebral segments respectively while non-recurrent ATM had 1.6 vertebral segments. Four (80%) of the five patients with NMO or its variant had poor neurological prognosis versus only one (5%) of non-recurrent ATM patients. IRTM patients had advanced mean onset age, 62 years vs. 43 years for non-recurrent ATM patients. In IIDD patients presenting with ATM as first attack of neuroinflammation, NMO and its variant (56%) were most frequent, then IRTM (33%), with classical MS (11%) the rarest. As long-term treatments for NMO are different from MS, early recognition of NMO and its variant is important for prevention of serious neurological deficits. © 2006 EFNS.
Persistent Identifierhttp://hdl.handle.net/10722/163001
ISSN
2015 Impact Factor: 3.956
2015 SCImago Journal Rankings: 1.669
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KHen_US
dc.contributor.authorTsang, KLen_US
dc.contributor.authorFong, GCYen_US
dc.contributor.authorHo, SLen_US
dc.contributor.authorCheung, RTFen_US
dc.contributor.authorMak, Wen_US
dc.date.accessioned2012-09-05T05:26:24Z-
dc.date.available2012-09-05T05:26:24Z-
dc.date.issued2006en_US
dc.identifier.citationEuropean Journal Of Neurology, 2006, v. 13 n. 8, p. 862-868en_US
dc.identifier.issn1351-5101en_US
dc.identifier.urihttp://hdl.handle.net/10722/163001-
dc.description.abstractAcute transverse myelitis (ATM) is commonly para-infectious. Recurrent ATM occurs in connective tissue diseases (CTD), infective myelitis and idiopathic inflammatory demyelinating disorders (IIDD) including multiple sclerosis (MS) and neuromyelitis optica (NMO). Previous studies might include NMO and idiopathic recurrent transverse myelitis (IRTM) as MS. The aim was to study the outcome of patients after a first attack of idiopathic ATM. Idiopathic ATM patients over a 6-year period were retrospectively studied. Known causes of myelopathy were excluded. Among 32 patients studied, 20 (63%) had single ATM attack upon follow up for 39-93 months, three developed recurrent ATM related to CTD (two systemic lupus erythematosus and one anti-Ro antibody positive) and nine (28.1%) developed recurrent neuroinflammation compatible with IIDD. Among IIDD patients, three had NMO, two restricted variant of NMO, three IRTM and one classical MS. NMO, its variant and IRTM had mean spinal MRI abnormality of 3.7, 2.1 and 3.9 vertebral segments respectively while non-recurrent ATM had 1.6 vertebral segments. Four (80%) of the five patients with NMO or its variant had poor neurological prognosis versus only one (5%) of non-recurrent ATM patients. IRTM patients had advanced mean onset age, 62 years vs. 43 years for non-recurrent ATM patients. In IIDD patients presenting with ATM as first attack of neuroinflammation, NMO and its variant (56%) were most frequent, then IRTM (33%), with classical MS (11%) the rarest. As long-term treatments for NMO are different from MS, early recognition of NMO and its variant is important for prevention of serious neurological deficits. © 2006 EFNS.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ENEen_US
dc.relation.ispartofEuropean Journal of Neurologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntiviral Agents - Therapeutic Useen_US
dc.subject.meshBrain - Pathology - Virologyen_US
dc.subject.meshDemyelinating Diseases - Diagnosis - Etiology - Therapyen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyelitis, Transverse - Complications - Diagnosis - Physiopathology - Therapyen_US
dc.subject.meshRetrospective Studiesen_US
dc.titleIdiopathic inflammatory demyelinating disorders after acute transverse myelitisen_US
dc.typeArticleen_US
dc.identifier.emailHo, SL:slho@hku.hken_US
dc.identifier.emailCheung, RTF:rtcheung@hku.hken_US
dc.identifier.authorityHo, SL=rp00240en_US
dc.identifier.authorityCheung, RTF=rp00434en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1468-1331.2006.01376.xen_US
dc.identifier.pmid16879297-
dc.identifier.scopuseid_2-s2.0-33746413762en_US
dc.identifier.hkuros119375-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746413762&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume13en_US
dc.identifier.issue8en_US
dc.identifier.spage862en_US
dc.identifier.epage868en_US
dc.identifier.eissn1468-1331-
dc.identifier.isiWOS:000239188200018-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChan, KH=7406034963en_US
dc.identifier.scopusauthoridTsang, KL=7201554745en_US
dc.identifier.scopusauthoridFong, GCY=36726526600en_US
dc.identifier.scopusauthoridHo, SL=25959633500en_US
dc.identifier.scopusauthoridCheung, RTF=7202397498en_US
dc.identifier.scopusauthoridMak, W=22948344000en_US
dc.identifier.citeulike773880-

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