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Article: Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region

TitleNomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region
Authors
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
Hepatology, 2001, v. 33 n. 3, p. 751-757 How to Cite?
AbstractThere is currently no universally accepted numbering convention for the antiviral drug-related resistance mutations in the reverse transcriptase (rt) domain of the human hepatitis B virus (HBV) polymerase. The published inconsistencies have resulted from different HBV genotypes. A standardized numbering system for HBV polymerase is proposed. The new system is based on functional observations of HBV surface gene proteins (preS1, preS2, and HBsAg) and on the current convention used for human immunodeficiency virus type 1 (HIV-1) polymerase proteins (protease, rt, and integrase), in which the amino acid numbering restarts at the first codon position of each domain. The HBV polymerase protein can be divided into 4 domains (terminal protein, spacer, rt, ribonuclease H) and each of these can be numbered separately. In this proposal, the HBV rt domain starts with the highly conserved EDWGPCDEHG motif, contains 344 amino acids, and the lamivudine-related resistance mutations are found at amino acid rtL180M (previously amino acid 528, 526, 515, or 525) and rtM204V/I (previously 552, 550, 539, or 549). The new consensus rt domain numbering system is genotype independent and allows investigators to number any previously and newly discovered antiviral-related amino acid change in a standardized manner.
Persistent Identifierhttp://hdl.handle.net/10722/162826
ISSN
2015 Impact Factor: 11.711
2015 SCImago Journal Rankings: 4.752
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorStuyver, LJen_US
dc.contributor.authorLocarnini, SAen_US
dc.contributor.authorLok, Aen_US
dc.contributor.authorRichman, DDen_US
dc.contributor.authorCarman, WFen_US
dc.contributor.authorDienstag, JLen_US
dc.contributor.authorSchinazi, RFen_US
dc.contributor.authorBartholomeusz, Aen_US
dc.contributor.authorDi Bisceglie, Aen_US
dc.contributor.authorDe Man, RAen_US
dc.contributor.authorDusheiko, Gen_US
dc.contributor.authorFurman, PAen_US
dc.contributor.authorLa Colla, Pen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorLau, JYNen_US
dc.contributor.authorManns, MPen_US
dc.contributor.authorNiesters, HGMen_US
dc.contributor.authorOmata, Men_US
dc.contributor.authorOnoNita, SKen_US
dc.contributor.authorOtto, MJen_US
dc.contributor.authorPillay, Den_US
dc.contributor.authorPoynard, Ten_US
dc.contributor.authorSommadossi, JPen_US
dc.contributor.authorShouval, Den_US
dc.contributor.authorSoriano, Ven_US
dc.contributor.authorThomas, Hen_US
dc.contributor.authorWill, Hen_US
dc.contributor.authorZoulim, Fen_US
dc.date.accessioned2012-09-05T05:24:00Z-
dc.date.available2012-09-05T05:24:00Z-
dc.date.issued2001en_US
dc.identifier.citationHepatology, 2001, v. 33 n. 3, p. 751-757en_US
dc.identifier.issn0270-9139en_US
dc.identifier.urihttp://hdl.handle.net/10722/162826-
dc.description.abstractThere is currently no universally accepted numbering convention for the antiviral drug-related resistance mutations in the reverse transcriptase (rt) domain of the human hepatitis B virus (HBV) polymerase. The published inconsistencies have resulted from different HBV genotypes. A standardized numbering system for HBV polymerase is proposed. The new system is based on functional observations of HBV surface gene proteins (preS1, preS2, and HBsAg) and on the current convention used for human immunodeficiency virus type 1 (HIV-1) polymerase proteins (protease, rt, and integrase), in which the amino acid numbering restarts at the first codon position of each domain. The HBV polymerase protein can be divided into 4 domains (terminal protein, spacer, rt, ribonuclease H) and each of these can be numbered separately. In this proposal, the HBV rt domain starts with the highly conserved EDWGPCDEHG motif, contains 344 amino acids, and the lamivudine-related resistance mutations are found at amino acid rtL180M (previously amino acid 528, 526, 515, or 525) and rtM204V/I (previously 552, 550, 539, or 549). The new consensus rt domain numbering system is genotype independent and allows investigators to number any previously and newly discovered antiviral-related amino acid change in a standardized manner.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/en_US
dc.relation.ispartofHepatologyen_US
dc.subject.meshAmino Acid Sequence - Geneticsen_US
dc.subject.meshAntiviral Agents - Pharmacologyen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshGene Products, Pol - Geneticsen_US
dc.subject.meshGenomeen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHepatitis B Virus - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshMutationen_US
dc.subject.meshTerminology As Topicen_US
dc.titleNomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase regionen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1053/jhep.2001.22166en_US
dc.identifier.pmid11230757-
dc.identifier.scopuseid_2-s2.0-17744375593en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17744375593&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue3en_US
dc.identifier.spage751en_US
dc.identifier.epage757en_US
dc.identifier.isiWOS:000167274200032-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridStuyver, LJ=7004164328en_US
dc.identifier.scopusauthoridLocarnini, SA=35953095500en_US
dc.identifier.scopusauthoridLok, A=35379868500en_US
dc.identifier.scopusauthoridRichman, DD=7202383409en_US
dc.identifier.scopusauthoridCarman, WF=7004473265en_US
dc.identifier.scopusauthoridDienstag, JL=24498972800en_US
dc.identifier.scopusauthoridSchinazi, RF=36049673200en_US
dc.identifier.scopusauthoridBartholomeusz, A=6701915061en_US
dc.identifier.scopusauthoridDi Bisceglie, A=7101900804en_US
dc.identifier.scopusauthoridDe Man, RA=7006113112en_US
dc.identifier.scopusauthoridDusheiko, G=7006885162en_US
dc.identifier.scopusauthoridFurman, PA=7005100858en_US
dc.identifier.scopusauthoridLa Colla, P=26643125000en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridLau, JYN=7402446047en_US
dc.identifier.scopusauthoridManns, MP=7202889076en_US
dc.identifier.scopusauthoridNiesters, HGM=7006807127en_US
dc.identifier.scopusauthoridOmata, M=36043368300en_US
dc.identifier.scopusauthoridOnoNita, SK=6603074265en_US
dc.identifier.scopusauthoridOtto, MJ=7201539762en_US
dc.identifier.scopusauthoridPillay, D=7101945946en_US
dc.identifier.scopusauthoridPoynard, T=7103155394en_US
dc.identifier.scopusauthoridSommadossi, JP=7006710590en_US
dc.identifier.scopusauthoridShouval, D=7006175997en_US
dc.identifier.scopusauthoridSoriano, V=7201761180en_US
dc.identifier.scopusauthoridThomas, H=7403743110en_US
dc.identifier.scopusauthoridWill, H=7102294104en_US
dc.identifier.scopusauthoridZoulim, F=7006912131en_US

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