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Article: Hypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilation
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TitleHypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilation
 
AuthorsTan, KCB1
Xu, A1
Chow, WS1
Lam, MCW1
Ai, VHG2
Tam, SCF2
Lam, KSL1
 
Issue Date2004
 
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
 
CitationJournal Of Clinical Endocrinology And Metabolism, 2004, v. 89 n. 2, p. 765-769 [How to Cite?]
DOI: http://dx.doi.org/10.1210/jc.2003-031012
 
AbstractAdiponectin may have an antiatherogenic effect by reducing endothelial activation. We hypothesized that plasma adiponectin levels were correlated with endothelial function. Plasma adiponectin level was determined by an in-house RIA assay using a rabbit polyclonal antibody in 73 type 2 diabetic patients and 73 controls. Endothelium-dependent and independent vasodilation of the brachial artery was measured by high-resolution vascular ultrasound. Plasma adiponectin level was lower in diabetic patients than in controls (4.73 ± 1.96 vs. 7.69 ± 2.80 μg/ml, respectively; P < 0.001), and they also had impaired endothelium-dependent (5.6 ± 3.6 vs. 8.6 ± 4.5%, respectively; P < 0.001) and -independent vasodilation (13.3 ± 4.9 vs. 16.5 ± 5.6%, respectively; P < 0.001). Plasma adiponectin correlated with endothelium-dependent vasodilation in controls (P = 0.02) and diabetic patients (P = 0.04). On general linear-model univariate analysis, brachial artery diameter, the presence of diabetes, plasma adiponectin, and high-density lipoprotein were significant independent determinants of endothelium-dependent vasodilation. In vitro experiments showed that endothelial cells expressed adiponectin receptors, and adiponectin increased nitric oxide production in human aortic endothelial cells. In conclusion, low plasma adiponectin level is associated with impaired endothelium-dependent vasodilation, and the association is independent of diabetes mellitus. Adiponectin may act as a link between adipose tissue and the vasculature.
 
ISSN0021-972X
2012 Impact Factor: 6.43
2012 SCImago Journal Rankings: 2.555
 
DOIhttp://dx.doi.org/10.1210/jc.2003-031012
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTan, KCB
 
dc.contributor.authorXu, A
 
dc.contributor.authorChow, WS
 
dc.contributor.authorLam, MCW
 
dc.contributor.authorAi, VHG
 
dc.contributor.authorTam, SCF
 
dc.contributor.authorLam, KSL
 
dc.date.accessioned2012-09-05T05:23:34Z
 
dc.date.available2012-09-05T05:23:34Z
 
dc.date.issued2004
 
dc.description.abstractAdiponectin may have an antiatherogenic effect by reducing endothelial activation. We hypothesized that plasma adiponectin levels were correlated with endothelial function. Plasma adiponectin level was determined by an in-house RIA assay using a rabbit polyclonal antibody in 73 type 2 diabetic patients and 73 controls. Endothelium-dependent and independent vasodilation of the brachial artery was measured by high-resolution vascular ultrasound. Plasma adiponectin level was lower in diabetic patients than in controls (4.73 ± 1.96 vs. 7.69 ± 2.80 μg/ml, respectively; P < 0.001), and they also had impaired endothelium-dependent (5.6 ± 3.6 vs. 8.6 ± 4.5%, respectively; P < 0.001) and -independent vasodilation (13.3 ± 4.9 vs. 16.5 ± 5.6%, respectively; P < 0.001). Plasma adiponectin correlated with endothelium-dependent vasodilation in controls (P = 0.02) and diabetic patients (P = 0.04). On general linear-model univariate analysis, brachial artery diameter, the presence of diabetes, plasma adiponectin, and high-density lipoprotein were significant independent determinants of endothelium-dependent vasodilation. In vitro experiments showed that endothelial cells expressed adiponectin receptors, and adiponectin increased nitric oxide production in human aortic endothelial cells. In conclusion, low plasma adiponectin level is associated with impaired endothelium-dependent vasodilation, and the association is independent of diabetes mellitus. Adiponectin may act as a link between adipose tissue and the vasculature.
 
dc.description.natureLink_to_OA_fulltext
 
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 2004, v. 89 n. 2, p. 765-769 [How to Cite?]
DOI: http://dx.doi.org/10.1210/jc.2003-031012
 
dc.identifier.doihttp://dx.doi.org/10.1210/jc.2003-031012
 
dc.identifier.epage769
 
dc.identifier.hkuros98228
 
dc.identifier.issn0021-972X
2012 Impact Factor: 6.43
2012 SCImago Journal Rankings: 2.555
 
dc.identifier.issue2
 
dc.identifier.pmid14764794
 
dc.identifier.scopuseid_2-s2.0-1442327754
 
dc.identifier.spage765
 
dc.identifier.urihttp://hdl.handle.net/10722/162791
 
dc.identifier.volume89
 
dc.languageeng
 
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolism
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdiponectin
 
dc.subject.meshAorta - Cytology - Metabolism
 
dc.subject.meshBrachial Artery - Physiopathology
 
dc.subject.meshCase-Control Studies
 
dc.subject.meshCells, Cultured
 
dc.subject.meshDiabetes Mellitus, Type 2 - Blood - Physiopathology - Ultrasonography
 
dc.subject.meshEndothelium, Vascular - Cytology - Physiopathology - Ultrasonography
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshIntercellular Signaling Peptides And Proteins
 
dc.subject.meshLipoproteins, Hdl - Blood
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNitric Oxide - Biosynthesis
 
dc.subject.meshProteins - Metabolism - Pharmacology
 
dc.subject.meshReceptors, Cell Surface - Metabolism
 
dc.subject.meshVasodilation
 
dc.titleHypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilation
 
dc.typeArticle
 
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<contributor.author>Lam, MCW</contributor.author>
<contributor.author>Ai, VHG</contributor.author>
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<contributor.author>Lam, KSL</contributor.author>
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<description.abstract>Adiponectin may have an antiatherogenic effect by reducing endothelial activation. We hypothesized that plasma adiponectin levels were correlated with endothelial function. Plasma adiponectin level was determined by an in-house RIA assay using a rabbit polyclonal antibody in 73 type 2 diabetic patients and 73 controls. Endothelium-dependent and independent vasodilation of the brachial artery was measured by high-resolution vascular ultrasound. Plasma adiponectin level was lower in diabetic patients than in controls (4.73 &#177; 1.96 vs. 7.69 &#177; 2.80 &#956;g/ml, respectively; P &lt; 0.001), and they also had impaired endothelium-dependent (5.6 &#177; 3.6 vs. 8.6 &#177; 4.5%, respectively; P &lt; 0.001) and -independent vasodilation (13.3 &#177; 4.9 vs. 16.5 &#177; 5.6%, respectively; P &lt; 0.001). Plasma adiponectin correlated with endothelium-dependent vasodilation in controls (P = 0.02) and diabetic patients (P = 0.04). On general linear-model univariate analysis, brachial artery diameter, the presence of diabetes, plasma adiponectin, and high-density lipoprotein were significant independent determinants of endothelium-dependent vasodilation. In vitro experiments showed that endothelial cells expressed adiponectin receptors, and adiponectin increased nitric oxide production in human aortic endothelial cells. In conclusion, low plasma adiponectin level is associated with impaired endothelium-dependent vasodilation, and the association is independent of diabetes mellitus. Adiponectin may act as a link between adipose tissue and the vasculature.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong