Article: Hypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilation

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TitleHypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilation
AuthorsTan, KCB1
Xu, A1
Chow, WS
Lam, MCW1
Ai, VHG2
Tam, SCF2
Lam, KSL1
Issue Date2004
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
CitationJournal Of Clinical Endocrinology And Metabolism, 2004, v. 89 n. 2, p. 765-769 [How to Cite?]
DOI: http://dx.doi.org/10.1210/jc.2003-031012
AbstractAdiponectin may have an antiatherogenic effect by reducing endothelial activation. We hypothesized that plasma adiponectin levels were correlated with endothelial function. Plasma adiponectin level was determined by an in-house RIA assay using a rabbit polyclonal antibody in 73 type 2 diabetic patients and 73 controls. Endothelium-dependent and independent vasodilation of the brachial artery was measured by high-resolution vascular ultrasound. Plasma adiponectin level was lower in diabetic patients than in controls (4.73 ± 1.96 vs. 7.69 ± 2.80 μg/ml, respectively; P < 0.001), and they also had impaired endothelium-dependent (5.6 ± 3.6 vs. 8.6 ± 4.5%, respectively; P < 0.001) and -independent vasodilation (13.3 ± 4.9 vs. 16.5 ± 5.6%, respectively; P < 0.001). Plasma adiponectin correlated with endothelium-dependent vasodilation in controls (P = 0.02) and diabetic patients (P = 0.04). On general linear-model univariate analysis, brachial artery diameter, the presence of diabetes, plasma adiponectin, and high-density lipoprotein were significant independent determinants of endothelium-dependent vasodilation. In vitro experiments showed that endothelial cells expressed adiponectin receptors, and adiponectin increased nitric oxide production in human aortic endothelial cells. In conclusion, low plasma adiponectin level is associated with impaired endothelium-dependent vasodilation, and the association is independent of diabetes mellitus. Adiponectin may act as a link between adipose tissue and the vasculature.
ISSN0021-972X
2011 Impact Factor: 5.967
2011 SCImago Journal Rankings: 0.579
DOIhttp://dx.doi.org/10.1210/jc.2003-031012
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTan, KCB
dc.contributor.authorXu, A
dc.contributor.authorChow, WS
dc.contributor.authorLam, MCW
dc.contributor.authorAi, VHG
dc.contributor.authorTam, SCF
dc.contributor.authorLam, KSL
dc.date.accessioned2012-09-05T05:23:34Z
dc.date.available2012-09-05T05:23:34Z
dc.date.issued2004
dc.description.abstractAdiponectin may have an antiatherogenic effect by reducing endothelial activation. We hypothesized that plasma adiponectin levels were correlated with endothelial function. Plasma adiponectin level was determined by an in-house RIA assay using a rabbit polyclonal antibody in 73 type 2 diabetic patients and 73 controls. Endothelium-dependent and independent vasodilation of the brachial artery was measured by high-resolution vascular ultrasound. Plasma adiponectin level was lower in diabetic patients than in controls (4.73 ± 1.96 vs. 7.69 ± 2.80 μg/ml, respectively; P < 0.001), and they also had impaired endothelium-dependent (5.6 ± 3.6 vs. 8.6 ± 4.5%, respectively; P < 0.001) and -independent vasodilation (13.3 ± 4.9 vs. 16.5 ± 5.6%, respectively; P < 0.001). Plasma adiponectin correlated with endothelium-dependent vasodilation in controls (P = 0.02) and diabetic patients (P = 0.04). On general linear-model univariate analysis, brachial artery diameter, the presence of diabetes, plasma adiponectin, and high-density lipoprotein were significant independent determinants of endothelium-dependent vasodilation. In vitro experiments showed that endothelial cells expressed adiponectin receptors, and adiponectin increased nitric oxide production in human aortic endothelial cells. In conclusion, low plasma adiponectin level is associated with impaired endothelium-dependent vasodilation, and the association is independent of diabetes mellitus. Adiponectin may act as a link between adipose tissue and the vasculature.
dc.description.natureLink_to_OA_fulltext
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 2004, v. 89 n. 2, p. 765-769 [How to Cite?]
DOI: http://dx.doi.org/10.1210/jc.2003-031012
dc.identifier.doihttp://dx.doi.org/10.1210/jc.2003-031012
dc.identifier.epage769
dc.identifier.hkuros98228
dc.identifier.issn0021-972X
2011 Impact Factor: 5.967
2011 SCImago Journal Rankings: 0.579
dc.identifier.issue2
dc.identifier.pmid14764794
dc.identifier.scopuseid_2-s2.0-1442327754
dc.identifier.spage765
dc.identifier.urihttp://hdl.handle.net/10722/162791
dc.identifier.volume89
dc.languageeng
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolism
dc.relation.referencesReferences in Scopus
dc.subject.meshAdiponectin
dc.subject.meshAorta - Cytology - Metabolism
dc.subject.meshBrachial Artery - Physiopathology
dc.subject.meshCase-Control Studies
dc.subject.meshCells, Cultured
dc.subject.meshDiabetes Mellitus, Type 2 - Blood - Physiopathology - Ultrasonography
dc.subject.meshEndothelium, Vascular - Cytology - Physiopathology - Ultrasonography
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIntercellular Signaling Peptides And Proteins
dc.subject.meshLipoproteins, Hdl - Blood
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNitric Oxide - Biosynthesis
dc.subject.meshProteins - Metabolism - Pharmacology
dc.subject.meshReceptors, Cell Surface - Metabolism
dc.subject.meshVasodilation
dc.titleHypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilation
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong