File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Hypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilation

TitleHypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilation
Authors
Issue Date2004
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
Citation
Journal Of Clinical Endocrinology And Metabolism, 2004, v. 89 n. 2, p. 765-769 How to Cite?
Abstract
Adiponectin may have an antiatherogenic effect by reducing endothelial activation. We hypothesized that plasma adiponectin levels were correlated with endothelial function. Plasma adiponectin level was determined by an in-house RIA assay using a rabbit polyclonal antibody in 73 type 2 diabetic patients and 73 controls. Endothelium-dependent and independent vasodilation of the brachial artery was measured by high-resolution vascular ultrasound. Plasma adiponectin level was lower in diabetic patients than in controls (4.73 ± 1.96 vs. 7.69 ± 2.80 μg/ml, respectively; P < 0.001), and they also had impaired endothelium-dependent (5.6 ± 3.6 vs. 8.6 ± 4.5%, respectively; P < 0.001) and -independent vasodilation (13.3 ± 4.9 vs. 16.5 ± 5.6%, respectively; P < 0.001). Plasma adiponectin correlated with endothelium-dependent vasodilation in controls (P = 0.02) and diabetic patients (P = 0.04). On general linear-model univariate analysis, brachial artery diameter, the presence of diabetes, plasma adiponectin, and high-density lipoprotein were significant independent determinants of endothelium-dependent vasodilation. In vitro experiments showed that endothelial cells expressed adiponectin receptors, and adiponectin increased nitric oxide production in human aortic endothelial cells. In conclusion, low plasma adiponectin level is associated with impaired endothelium-dependent vasodilation, and the association is independent of diabetes mellitus. Adiponectin may act as a link between adipose tissue and the vasculature.
Persistent Identifierhttp://hdl.handle.net/10722/162791
ISSN
2013 Impact Factor: 6.310
2013 SCImago Journal Rankings: 3.169
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong
DC FieldValueLanguage
dc.contributor.authorTan, KCBen_US
dc.contributor.authorXu, Aen_US
dc.contributor.authorChow, WSen_US
dc.contributor.authorLam, MCWen_US
dc.contributor.authorAi, VHGen_US
dc.contributor.authorTam, SCFen_US
dc.contributor.authorLam, KSLen_US
dc.date.accessioned2012-09-05T05:23:34Z-
dc.date.available2012-09-05T05:23:34Z-
dc.date.issued2004en_US
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 2004, v. 89 n. 2, p. 765-769en_US
dc.identifier.issn0021-972Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/162791-
dc.description.abstractAdiponectin may have an antiatherogenic effect by reducing endothelial activation. We hypothesized that plasma adiponectin levels were correlated with endothelial function. Plasma adiponectin level was determined by an in-house RIA assay using a rabbit polyclonal antibody in 73 type 2 diabetic patients and 73 controls. Endothelium-dependent and independent vasodilation of the brachial artery was measured by high-resolution vascular ultrasound. Plasma adiponectin level was lower in diabetic patients than in controls (4.73 ± 1.96 vs. 7.69 ± 2.80 μg/ml, respectively; P < 0.001), and they also had impaired endothelium-dependent (5.6 ± 3.6 vs. 8.6 ± 4.5%, respectively; P < 0.001) and -independent vasodilation (13.3 ± 4.9 vs. 16.5 ± 5.6%, respectively; P < 0.001). Plasma adiponectin correlated with endothelium-dependent vasodilation in controls (P = 0.02) and diabetic patients (P = 0.04). On general linear-model univariate analysis, brachial artery diameter, the presence of diabetes, plasma adiponectin, and high-density lipoprotein were significant independent determinants of endothelium-dependent vasodilation. In vitro experiments showed that endothelial cells expressed adiponectin receptors, and adiponectin increased nitric oxide production in human aortic endothelial cells. In conclusion, low plasma adiponectin level is associated with impaired endothelium-dependent vasodilation, and the association is independent of diabetes mellitus. Adiponectin may act as a link between adipose tissue and the vasculature.en_US
dc.languageengen_US
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.orgen_US
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_US
dc.subject.meshAdiponectinen_US
dc.subject.meshAorta - Cytology - Metabolismen_US
dc.subject.meshBrachial Artery - Physiopathologyen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshDiabetes Mellitus, Type 2 - Blood - Physiopathology - Ultrasonographyen_US
dc.subject.meshEndothelium, Vascular - Cytology - Physiopathology - Ultrasonographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIntercellular Signaling Peptides And Proteinsen_US
dc.subject.meshLipoproteins, Hdl - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNitric Oxide - Biosynthesisen_US
dc.subject.meshProteins - Metabolism - Pharmacologyen_US
dc.subject.meshReceptors, Cell Surface - Metabolismen_US
dc.subject.meshVasodilationen_US
dc.titleHypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilationen_US
dc.typeArticleen_US
dc.identifier.emailTan, KCB:kcbtan@hku.hken_US
dc.identifier.emailXu, A:amxu@hkucc.hku.hken_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.authorityTan, KCB=rp00402en_US
dc.identifier.authorityXu, A=rp00485en_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1210/jc.2003-031012en_US
dc.identifier.pmid14764794en_US
dc.identifier.scopuseid_2-s2.0-1442327754en_US
dc.identifier.hkuros98228-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1442327754&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume89en_US
dc.identifier.issue2en_US
dc.identifier.spage765en_US
dc.identifier.epage769en_US
dc.identifier.isiWOS:000188763900050-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTan, KCB=8082703100en_US
dc.identifier.scopusauthoridXu, A=7202655409en_US
dc.identifier.scopusauthoridChow, WS=7402281153en_US
dc.identifier.scopusauthoridLam, MCW=36879143100en_US
dc.identifier.scopusauthoridAi, VHG=6603342063en_US
dc.identifier.scopusauthoridTam, SCF=7202037323en_US
dc.identifier.scopusauthoridLam, KSL=8082870600en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats