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Article: Diabetic nephropathy is associated with the 5′-end dinucleotide repeat polymorphism of the aldose reductase gene in Chinese subjects with Type 2 diabetes

TitleDiabetic nephropathy is associated with the 5′-end dinucleotide repeat polymorphism of the aldose reductase gene in Chinese subjects with Type 2 diabetes
Authors
KeywordsAldose reductase
Chinese
Gene
Nephropathy
Polymorphism
Type 2 diabetes
Issue Date2002
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DME
Citation
Diabetic Medicine, 2002, v. 19 n. 2, p. 113-118 How to Cite?
AbstractAims: We investigated whether the promoter dinucleotide repeat polymorphism of the aldose reductase gene (5′-ALR2), implicated in the development of nephropathy in Type 1 diabetes, was associated with diabetic nephropathy in Type 2 diabetes. Methods: In 265 Southern Chinese with Type 2 diabetes the 5′-ALR2 polymorphism was identified in genomic DNA using polymerase chain reaction and automated fluorescent scanning. They were classified as normoalbuminuric (n = 128), microalbuminuric (n = 85) or albuminuric (n = 52) according to the mean albumin excretion rate of two 12-h overnight collections. Results: The 5′-ALR2 allele and genotype distributions differed significantly among the three groups of patients (P < 0.003 and P < 0.01, respectively). Normoalbuminuric patients had the lowest Z - 2 allele frequency: 17.6% vs. 28.2% and 23.1% for microalbuminuric and albuminuric patients, respectively, and the highest Z + 2 allele frequency: 36.7% vs. 21.2% and 23.1% in microalbuminuric and albuminuric patients, respectively. They also had the lowest Z - 2/X genotype frequency (X = any allele other than Z + 2): 18.8% vs. 36.5% in microalbuminuric (P < 0.01) and 38.5% in albuminuric patients (P < 0.02), respectively, but the highest Z + 2/Y genotype frequency (Y = any allele other than Z - 2): 50.7% vs. 27.0% and 34.6% in microalbuminuric (P < 0.001) and albuminuric patients, respectively. In a multiple logistic regression model, the Z - 2/X genotype (odds ratio 3.10; P < 0.025) was an independent risk factor of diabetic nephropathy, microalbuminuria or albuminuria, together with age, mean arterial pressure and body mass index. Conclusions: The 5′-ALR2 dinucleotide repeat polymorphism is associated with the development of diabetic nephropathy in Southern Chinese with Type 2 diabetes.
Persistent Identifierhttp://hdl.handle.net/10722/162577
ISSN
2015 Impact Factor: 3.152
2015 SCImago Journal Rankings: 1.654
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, YFen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorChung, SSMen_HK
dc.contributor.authorKo, BCBen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2012-09-05T05:21:21Z-
dc.date.available2012-09-05T05:21:21Z-
dc.date.issued2002en_HK
dc.identifier.citationDiabetic Medicine, 2002, v. 19 n. 2, p. 113-118en_HK
dc.identifier.issn0742-3071en_HK
dc.identifier.urihttp://hdl.handle.net/10722/162577-
dc.description.abstractAims: We investigated whether the promoter dinucleotide repeat polymorphism of the aldose reductase gene (5′-ALR2), implicated in the development of nephropathy in Type 1 diabetes, was associated with diabetic nephropathy in Type 2 diabetes. Methods: In 265 Southern Chinese with Type 2 diabetes the 5′-ALR2 polymorphism was identified in genomic DNA using polymerase chain reaction and automated fluorescent scanning. They were classified as normoalbuminuric (n = 128), microalbuminuric (n = 85) or albuminuric (n = 52) according to the mean albumin excretion rate of two 12-h overnight collections. Results: The 5′-ALR2 allele and genotype distributions differed significantly among the three groups of patients (P < 0.003 and P < 0.01, respectively). Normoalbuminuric patients had the lowest Z - 2 allele frequency: 17.6% vs. 28.2% and 23.1% for microalbuminuric and albuminuric patients, respectively, and the highest Z + 2 allele frequency: 36.7% vs. 21.2% and 23.1% in microalbuminuric and albuminuric patients, respectively. They also had the lowest Z - 2/X genotype frequency (X = any allele other than Z + 2): 18.8% vs. 36.5% in microalbuminuric (P < 0.01) and 38.5% in albuminuric patients (P < 0.02), respectively, but the highest Z + 2/Y genotype frequency (Y = any allele other than Z - 2): 50.7% vs. 27.0% and 34.6% in microalbuminuric (P < 0.001) and albuminuric patients, respectively. In a multiple logistic regression model, the Z - 2/X genotype (odds ratio 3.10; P < 0.025) was an independent risk factor of diabetic nephropathy, microalbuminuria or albuminuria, together with age, mean arterial pressure and body mass index. Conclusions: The 5′-ALR2 dinucleotide repeat polymorphism is associated with the development of diabetic nephropathy in Southern Chinese with Type 2 diabetes.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DMEen_HK
dc.relation.ispartofDiabetic Medicineen_HK
dc.rightsDiabetic Medicine. Copyright © Blackwell Publishing Ltd.-
dc.subjectAldose reductaseen_HK
dc.subjectChineseen_HK
dc.subjectGeneen_HK
dc.subjectNephropathyen_HK
dc.subjectPolymorphismen_HK
dc.subjectType 2 diabetesen_HK
dc.subject.mesh5' Untranslated Regions - Geneticsen_US
dc.subject.meshAlbuminuria - Geneticsen_US
dc.subject.meshAldehyde Reductase - Geneticsen_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshChinaen_US
dc.subject.meshDiabetes Mellitus, Type 2 - Geneticsen_US
dc.subject.meshDiabetic Nephropathies - Geneticsen_US
dc.subject.meshDinucleotide Repeatsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kong - Ethnologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPromoter Regions, Geneticen_US
dc.subject.meshRisk Factorsen_US
dc.titleDiabetic nephropathy is associated with the 5′-end dinucleotide repeat polymorphism of the aldose reductase gene in Chinese subjects with Type 2 diabetesen_HK
dc.typeArticleen_HK
dc.identifier.emailChung, SSM: smchung@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityChung, SSM=rp00376en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1464-5491.2002.00632.xen_HK
dc.identifier.pmid11874426-
dc.identifier.scopuseid_2-s2.0-0036125236en_HK
dc.identifier.hkuros79296-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036125236&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue2en_HK
dc.identifier.spage113en_HK
dc.identifier.epage118en_HK
dc.identifier.isiWOS:000174576300005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLiu, YF=38262263600en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridChung, SSM=14120761600en_HK
dc.identifier.scopusauthoridKo, BCB=7102833927en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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