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Article: Post-transplantation lymphoproliferative disease of natural killer cell lineage: A clinicopathological and molecular analysis

TitlePost-transplantation lymphoproliferative disease of natural killer cell lineage: A clinicopathological and molecular analysis
Authors
Issue Date2000
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2000, v. 110 n. 1, p. 197-202 How to Cite?
AbstractPost-transplantation lymphoproliferative disorders (PTLD) occur after solid organ and bone marrow transplantation. They are predominantly of B-cell and occasionally of T-cell lineage. We report a case of PTLD of natural killer (NK) cell lineage. A renal allograft recipient developed progressive pancytopenia 1 year after transplantation. Serial bone marrow biopsies showed an increasing infiltration by large granular lymphoid cells. A subsequent leukaemic phase also developed with systemic infiltration of other organs. Immunophenotyping showed that these cells were CD2+, CD3-, CD3ε+, CD56+, CD94+, CD158a- and CD158b-. In situ hybridization showed Epstein-Barr virus (EBV) infection of the neoplastic cells. Genotypical analysis showed the T-cell receptor gene in germline configuration and clonal EBV episomal integration. The overall features were consistent with NK cell lymphoma/leukaemia. The patient did not respond to cessation of immunosuppression or anti-EBV treatment. Combination chemotherapy was given, but the patient died ultimately of disseminated fungal infection. In conclusion, we have demonstrated that NK cell lymphoma is another rare type of PTLD that appears to be highly aggressive and therefore may require early chemotherapy to improve treatment outcome.
Persistent Identifierhttp://hdl.handle.net/10722/162394
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_US
dc.contributor.authorLam, CCKen_US
dc.contributor.authorChan, TMen_US
dc.date.accessioned2012-09-05T05:19:33Z-
dc.date.available2012-09-05T05:19:33Z-
dc.date.issued2000en_US
dc.identifier.citationBritish Journal Of Haematology, 2000, v. 110 n. 1, p. 197-202en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/162394-
dc.description.abstractPost-transplantation lymphoproliferative disorders (PTLD) occur after solid organ and bone marrow transplantation. They are predominantly of B-cell and occasionally of T-cell lineage. We report a case of PTLD of natural killer (NK) cell lineage. A renal allograft recipient developed progressive pancytopenia 1 year after transplantation. Serial bone marrow biopsies showed an increasing infiltration by large granular lymphoid cells. A subsequent leukaemic phase also developed with systemic infiltration of other organs. Immunophenotyping showed that these cells were CD2+, CD3-, CD3ε+, CD56+, CD94+, CD158a- and CD158b-. In situ hybridization showed Epstein-Barr virus (EBV) infection of the neoplastic cells. Genotypical analysis showed the T-cell receptor gene in germline configuration and clonal EBV episomal integration. The overall features were consistent with NK cell lymphoma/leukaemia. The patient did not respond to cessation of immunosuppression or anti-EBV treatment. Combination chemotherapy was given, but the patient died ultimately of disseminated fungal infection. In conclusion, we have demonstrated that NK cell lymphoma is another rare type of PTLD that appears to be highly aggressive and therefore may require early chemotherapy to improve treatment outcome.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAntigens, Cd - Analysisen_US
dc.subject.meshAntigens, Cd2 - Analysisen_US
dc.subject.meshAntigens, Cd3 - Analysisen_US
dc.subject.meshAntigens, Cd56 - Analysisen_US
dc.subject.meshBlotting, Southernen_US
dc.subject.meshDna, Viralen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshHerpesvirus 4, Human - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshKidney Failure, Chronic - Immunology - Surgery - Virologyen_US
dc.subject.meshKidney Transplantationen_US
dc.subject.meshKiller Cells, Natural - Immunologyen_US
dc.subject.meshLectins, C-Typeen_US
dc.subject.meshLeukemia, T-Cell - Diagnosis - Immunology - Virologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Glycoproteins - Analysisen_US
dc.subject.meshNk Cell Lectin-Like Receptor Subfamily Den_US
dc.subject.meshPostoperative Complications - Immunologyen_US
dc.subject.meshTransplantation, Homologousen_US
dc.titlePost-transplantation lymphoproliferative disease of natural killer cell lineage: A clinicopathological and molecular analysisen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.emailChan, TM:dtmchan@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.identifier.authorityChan, TM=rp00394en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1365-2141.2000.02138.xen_US
dc.identifier.pmid10930998-
dc.identifier.scopuseid_2-s2.0-0033887664en_US
dc.identifier.hkuros59699-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033887664&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume110en_US
dc.identifier.issue1en_US
dc.identifier.spage197en_US
dc.identifier.epage202en_US
dc.identifier.isiWOS:000088697500026-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.scopusauthoridLam, CCK=16947291300en_US
dc.identifier.scopusauthoridChan, TM=7402687700en_US

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