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Article: Acute leukaemia in acromegaly patients

TitleAcute leukaemia in acromegaly patients
Authors
Issue Date2000
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2000, v. 110 n. 4, p. 871-873 How to Cite?
AbstractAcromegaly patients are known to have an increased risk of malignancies, especially colonic adenocarcinoma. This may be as a result of the growth-stimulating effect of growth hormone (GH). The clustering of leukaemia in children treated with GH has also caused concern. There have been a few reports of leukaemia in acromegaly patients. We report two patients with acute lymphoblastic leukaemia and one patient with acute myeloid leukaemia among 106 acromegaly patients treated over a 15-year period. Two of the cases received radiotherapy as part of their treatment. Adjusted for age and follow-up years, the incidence of leukaemia in this cohort is significantly higher than the general population. The incidence is also higher than would be expected as a result of radiotherapy alone, suggesting that GH may play a synergistic role.
Persistent Identifierhttp://hdl.handle.net/10722/162375
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_US
dc.contributor.authorChow, WSen_US
dc.contributor.authorLam, KSLen_US
dc.contributor.authorKo, GTCen_US
dc.contributor.authorCockram, CSen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:19:23Z-
dc.date.available2012-09-05T05:19:23Z-
dc.date.issued2000en_US
dc.identifier.citationBritish Journal Of Haematology, 2000, v. 110 n. 4, p. 871-873en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/162375-
dc.description.abstractAcromegaly patients are known to have an increased risk of malignancies, especially colonic adenocarcinoma. This may be as a result of the growth-stimulating effect of growth hormone (GH). The clustering of leukaemia in children treated with GH has also caused concern. There have been a few reports of leukaemia in acromegaly patients. We report two patients with acute lymphoblastic leukaemia and one patient with acute myeloid leukaemia among 106 acromegaly patients treated over a 15-year period. Two of the cases received radiotherapy as part of their treatment. Adjusted for age and follow-up years, the incidence of leukaemia in this cohort is significantly higher than the general population. The incidence is also higher than would be expected as a result of radiotherapy alone, suggesting that GH may play a synergistic role.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAcromegaly - Complications - Surgeryen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdenoma - Complications - Secretion - Surgeryen_US
dc.subject.meshAdulten_US
dc.subject.meshBone Marrow Transplantationen_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGrowth Hormone - Secretionen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshLeukemia - Complicationsen_US
dc.subject.meshLeukemia, Myeloid - Complications - Therapyen_US
dc.subject.meshLeukemia-Lymphoma, Adult T-Cell - Complications - Therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshPituitary Neoplasms - Complications - Secretionen_US
dc.subject.meshRisken_US
dc.titleAcute leukaemia in acromegaly patientsen_US
dc.typeArticleen_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1046/j.1365-2141.2000.02262.xen_US
dc.identifier.pmid11054071-
dc.identifier.scopuseid_2-s2.0-0033760353en_US
dc.identifier.hkuros59921-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033760353&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume110en_US
dc.identifier.issue4en_US
dc.identifier.spage871en_US
dc.identifier.epage873en_US
dc.identifier.isiWOS:000089857800016-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridChow, WS=7402281153en_US
dc.identifier.scopusauthoridLam, KSL=8082870600en_US
dc.identifier.scopusauthoridKo, GTC=7103172871en_US
dc.identifier.scopusauthoridCockram, CS=7006379262en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US

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