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Article: Strong association between DQA1/DQB1 genotype and early-onset IDDM in Chinese: The association is with alleles rather than specific residues

TitleStrong association between DQA1/DQB1 genotype and early-onset IDDM in Chinese: The association is with alleles rather than specific residues
Authors
Issue Date1998
Citation
European Journal Of Immunogenetics, 1998, v. 25 n. 4, p. 273-280 How to Cite?
AbstractWe report on the role of HLA-DQA1 and DQB1 alleles in determining susceptibility to insulin-dependent diabetes mellitus (IDDM) in Hong Kong Chinese and investigate whether these alleles affect the age of onset of the disease. We studied 76 unrelated Chinese patients and 250 controls. There was no apparent predisposing effect of non-aspartic acid residues at position 57 of the DQβ chain (Asp57-) but there was an excess of homozygous genotypes containing arginine at position 52 of the DQα chain (Arg52+). This excess was mainly attributable to the genotype DQA1*0301/DQA1*05011 in early-onset disease. There was a significant excess of heterodimers of DQα and DQβ carrying Arg52+ and Asp57- in both early onset and late-onset disease, but the excess in early-onset disease was mainly attributable to a single heterodimer formed by DQA1*05011 and DQB1*0201. Of three DQA1/DQB1 genotypes containing a double dose of Arg52+ and Asp57-, only one had a strong association with both early-onset and late-onset disease. We show that early-onset IDDM and late-onset IDDM in Chinese may be separated on the basis of their associated DQA1 and DQB1 genotypes and we conclude that previously reported associations of IDDM with Arg52+ and Asp57- residues in Chinese are secondary to specific combinations of DQA1 and DQB1 alleles. We also show that DRB1 molecules play a distinct role in determining susceptibility to early-onset IDDM but the greatest effect is exerted by specific DR/DQ genotypic combinations.
Persistent Identifierhttp://hdl.handle.net/10722/162221
ISSN
2006 Impact Factor: 1.9
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChang, YWen_US
dc.contributor.authorLam, KSLen_US
dc.contributor.authorHawkins, BRen_US
dc.date.accessioned2012-09-05T05:18:12Z-
dc.date.available2012-09-05T05:18:12Z-
dc.date.issued1998en_US
dc.identifier.citationEuropean Journal Of Immunogenetics, 1998, v. 25 n. 4, p. 273-280en_US
dc.identifier.issn0960-7420en_US
dc.identifier.urihttp://hdl.handle.net/10722/162221-
dc.description.abstractWe report on the role of HLA-DQA1 and DQB1 alleles in determining susceptibility to insulin-dependent diabetes mellitus (IDDM) in Hong Kong Chinese and investigate whether these alleles affect the age of onset of the disease. We studied 76 unrelated Chinese patients and 250 controls. There was no apparent predisposing effect of non-aspartic acid residues at position 57 of the DQβ chain (Asp57-) but there was an excess of homozygous genotypes containing arginine at position 52 of the DQα chain (Arg52+). This excess was mainly attributable to the genotype DQA1*0301/DQA1*05011 in early-onset disease. There was a significant excess of heterodimers of DQα and DQβ carrying Arg52+ and Asp57- in both early onset and late-onset disease, but the excess in early-onset disease was mainly attributable to a single heterodimer formed by DQA1*05011 and DQB1*0201. Of three DQA1/DQB1 genotypes containing a double dose of Arg52+ and Asp57-, only one had a strong association with both early-onset and late-onset disease. We show that early-onset IDDM and late-onset IDDM in Chinese may be separated on the basis of their associated DQA1 and DQB1 genotypes and we conclude that previously reported associations of IDDM with Arg52+ and Asp57- residues in Chinese are secondary to specific combinations of DQA1 and DQB1 alleles. We also show that DRB1 molecules play a distinct role in determining susceptibility to early-onset IDDM but the greatest effect is exerted by specific DR/DQ genotypic combinations.en_US
dc.languageengen_US
dc.relation.ispartofEuropean Journal of Immunogeneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshAllelesen_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshDiabetes Mellitus, Type 1 - Ethnology - Genetics - Immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHla-Dq Antigens - Geneticsen_US
dc.subject.meshHla-Dq Alpha-Chainsen_US
dc.subject.meshHla-Dq Beta-Chainsen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleStrong association between DQA1/DQB1 genotype and early-onset IDDM in Chinese: The association is with alleles rather than specific residuesen_US
dc.typeArticleen_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1365-2370.1998.00109.xen_US
dc.identifier.pmid9777326en_US
dc.identifier.scopuseid_2-s2.0-0031684437en_US
dc.identifier.hkuros41473-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031684437&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume25en_US
dc.identifier.issue4en_US
dc.identifier.spage273en_US
dc.identifier.epage280en_US
dc.identifier.isiWOS:000075790000001-
dc.identifier.scopusauthoridChang, YW=7501843855en_US
dc.identifier.scopusauthoridLam, KSL=8082870600en_US
dc.identifier.scopusauthoridHawkins, BR=35944486200en_US

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