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Article: Frequency distributions of plasma apolipoprotein (a) levels and phenotypes: A comparison between southern and northern Chinese populations

TitleFrequency distributions of plasma apolipoprotein (a) levels and phenotypes: A comparison between southern and northern Chinese populations
Authors
Issue Date1997
PublisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 1997, v. 110 n. 6, p. 465-473 How to Cite?
AbstractObjective This study was designed to examine the genetic variation and levels of apolipoprotein (a) [apo(a)] in Chinese living in two different geographical regions of China and the influence of the apo(a) size polymorphism on plasma apo(a) levels. Methods An immunoradiometric assay was used to determine plasma apo(a) levels and a simplified and sensitive SDS-agarose gel electrophoresis method followed by immunoblotting with chemiluminescent detection for apo(a) phenotyping was employed to compare the frequency distributions of apo(a) levels and phenotypes in southern (Hong Kong) and northern (Henan) Chinese populations. Results Distributions of plasma apo(a) levels were highly skewed in both population groups- Although plasma apo(a) levels were generally higher in northern Chinese than in southern Chinese this was not explained by differences in K-IV repeats allele frequencies between these two population groups. The association of K-IV repeat length with apo(a) levels is similar in the two populations. Conclusions We conclude that besides the apo(a) size polymorphism, which is similar in these two Chinese populations, other factors affect apo(a) levels to a certain degree. Most likely, this is the sequence variation in apo(a) gene which may not be the same in different Chinese populations.
Persistent Identifierhttp://hdl.handle.net/10722/162206
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPang, RWCen_US
dc.contributor.authorChen, Ben_US
dc.contributor.authorJanus, EDen_US
dc.contributor.authorLam, KSen_US
dc.date.accessioned2012-09-05T05:18:08Z-
dc.date.available2012-09-05T05:18:08Z-
dc.date.issued1997en_US
dc.identifier.citationChinese Medical Journal, 1997, v. 110 n. 6, p. 465-473en_US
dc.identifier.issn0366-6999en_US
dc.identifier.urihttp://hdl.handle.net/10722/162206-
dc.description.abstractObjective This study was designed to examine the genetic variation and levels of apolipoprotein (a) [apo(a)] in Chinese living in two different geographical regions of China and the influence of the apo(a) size polymorphism on plasma apo(a) levels. Methods An immunoradiometric assay was used to determine plasma apo(a) levels and a simplified and sensitive SDS-agarose gel electrophoresis method followed by immunoblotting with chemiluminescent detection for apo(a) phenotyping was employed to compare the frequency distributions of apo(a) levels and phenotypes in southern (Hong Kong) and northern (Henan) Chinese populations. Results Distributions of plasma apo(a) levels were highly skewed in both population groups- Although plasma apo(a) levels were generally higher in northern Chinese than in southern Chinese this was not explained by differences in K-IV repeats allele frequencies between these two population groups. The association of K-IV repeat length with apo(a) levels is similar in the two populations. Conclusions We conclude that besides the apo(a) size polymorphism, which is similar in these two Chinese populations, other factors affect apo(a) levels to a certain degree. Most likely, this is the sequence variation in apo(a) gene which may not be the same in different Chinese populations.en_US
dc.languageengen_US
dc.publisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/en_US
dc.relation.ispartofChinese Medical Journalen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshApolipoproteins A - Blood - Geneticsen_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMass Screeningen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhenotypeen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.titleFrequency distributions of plasma apolipoprotein (a) levels and phenotypes: A comparison between southern and northern Chinese populationsen_US
dc.typeArticleen_US
dc.identifier.emailPang, RWC:robertap@hkucc.hku.hken_US
dc.identifier.emailLam, KS:ksllam@hku.hken_US
dc.identifier.authorityPang, RWC=rp00274en_US
dc.identifier.authorityLam, KS=rp00343en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid9594249-
dc.identifier.scopuseid_2-s2.0-0031152013en_US
dc.identifier.hkuros25927-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031152013&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume110en_US
dc.identifier.issue6en_US
dc.identifier.spage465en_US
dc.identifier.epage473en_US
dc.identifier.isiWOS:A1997XM38400013-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridPang, RWC=7004376659en_US
dc.identifier.scopusauthoridChen, B=7408611415en_US
dc.identifier.scopusauthoridJanus, ED=7006936536en_US
dc.identifier.scopusauthoridLam, KS=8082870600en_US

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