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Article: Aging impairs afferent nerve function in rat intestine. Reduction of mesenteric hyperemia induced by intraduodenal capsaicin and acid

TitleAging impairs afferent nerve function in rat intestine. Reduction of mesenteric hyperemia induced by intraduodenal capsaicin and acid
Authors
Issue Date1996
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
Citation
Digestive Diseases And Sciences, 1996, v. 41 n. 2, p. 346-351 How to Cite?
AbstractThe high incidence of peptic ulcer disease despite decreased acid secretion in the elderly suggests an impairment of mucosal defense mechanism with aging. Stimulation of the intestinal mucosal afferent nerves by intraduodenal application of capsaicin or hydrochloric acid (HCl) increases superior mesenteric artery (SMA) blood flow and protects the duodenal mucosa against deep damage. We tested the hypothesis that the intestinal hyperemia induced by intraduodenal capsaicin or HCl is significantly reduced in older (12 months) rats compared with younger (2 months) rats. Mesenteric blood flow was measured by pulsed Doppler flowmetry in anesthetized rats with the flow probe around the SMA. Two milliliters per kilogram of 160 μM capsaicin or 0.1 N HCl administered intraduodenally increased SMA blood flow significantly in both age groups. The peak response in SMA blood flow, however, was significantly smaller in the older rats than in the younger rats, These observations support the hypothesis that impairment of afferent nerve function occurs with aging in the rat intestine.
Persistent Identifierhttp://hdl.handle.net/10722/162146
ISSN
2015 Impact Factor: 2.516
2015 SCImago Journal Rankings: 0.995
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSeno, Ken_US
dc.contributor.authorLam, Ken_US
dc.contributor.authorLeung, JWCen_US
dc.contributor.authorLeung, FWen_US
dc.date.accessioned2012-09-05T05:17:37Z-
dc.date.available2012-09-05T05:17:37Z-
dc.date.issued1996en_US
dc.identifier.citationDigestive Diseases And Sciences, 1996, v. 41 n. 2, p. 346-351en_US
dc.identifier.issn0163-2116en_US
dc.identifier.urihttp://hdl.handle.net/10722/162146-
dc.description.abstractThe high incidence of peptic ulcer disease despite decreased acid secretion in the elderly suggests an impairment of mucosal defense mechanism with aging. Stimulation of the intestinal mucosal afferent nerves by intraduodenal application of capsaicin or hydrochloric acid (HCl) increases superior mesenteric artery (SMA) blood flow and protects the duodenal mucosa against deep damage. We tested the hypothesis that the intestinal hyperemia induced by intraduodenal capsaicin or HCl is significantly reduced in older (12 months) rats compared with younger (2 months) rats. Mesenteric blood flow was measured by pulsed Doppler flowmetry in anesthetized rats with the flow probe around the SMA. Two milliliters per kilogram of 160 μM capsaicin or 0.1 N HCl administered intraduodenally increased SMA blood flow significantly in both age groups. The peak response in SMA blood flow, however, was significantly smaller in the older rats than in the younger rats, These observations support the hypothesis that impairment of afferent nerve function occurs with aging in the rat intestine.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116en_US
dc.relation.ispartofDigestive Diseases and Sciencesen_US
dc.subject.meshAfferent Pathways - Physiologyen_US
dc.subject.meshAging - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCapsaicin - Administration & Dosageen_US
dc.subject.meshDuodenum - Drug Effects - Innervation - Physiologyen_US
dc.subject.meshHydrochloric Acid - Administration & Dosage - Pharmacologyen_US
dc.subject.meshHyperemia - Chemically Induced - Physiopathologyen_US
dc.subject.meshIntestinal Mucosa - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMesenteric Artery, Superior - Drug Effectsen_US
dc.subject.meshRatsen_US
dc.titleAging impairs afferent nerve function in rat intestine. Reduction of mesenteric hyperemia induced by intraduodenal capsaicin and aciden_US
dc.typeArticleen_US
dc.identifier.emailLam, K:ksllam@hku.hken_US
dc.identifier.authorityLam, K=rp00343en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF02093827en_US
dc.identifier.pmid8601381en_US
dc.identifier.scopuseid_2-s2.0-0029927353en_US
dc.identifier.volume41en_US
dc.identifier.issue2en_US
dc.identifier.spage346en_US
dc.identifier.epage351en_US
dc.identifier.isiWOS:A1996TX94400018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSeno, K=7004814371en_US
dc.identifier.scopusauthoridLam, K=8082870600en_US
dc.identifier.scopusauthoridLeung, JWC=7202180292en_US
dc.identifier.scopusauthoridLeung, FW=7103078612en_US

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