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Article: Correlation between serum HCV RNA and aminotransferase levels in patients with chronic HCV infection

TitleCorrelation between serum HCV RNA and aminotransferase levels in patients with chronic HCV infection
Authors
Issue Date1996
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
Citation
Digestive Diseases And Sciences, 1996, v. 41 n. 11, p. 2213-2218 How to Cite?
AbstractCross-sectional studies on the correlation between serum hepatitis C virus (HCV) RNA and alanine aminotransferase (ALT) levels in patients with chronic hepatitis C have yielded conflicting results. We conducted a longitudinal study to examine the correlation between HCV viremia and serum ALT levels in individual patients over time. Serial samples (mean 9) from 25 patients with chronic HCV infection, including interferon-treated and untreated immunocompetent and immunosuppressed patients, collected over a period of 1-4.8 years (mean 2.6 years) were tested for HCV RNA and ALT levels using a highly reproducible quantitative (bDNA) assay. A significant correlation was found between serum HCV RNA and ALT levels in the patients who received IFN therapy, but no correlation was observed in the untreated patients. Among the untreated patients, the immunosuppressed patients had significantly higher HCV RNA levels (39 ± 4 vs 3.6 ± 8 Meq/ml, P < 0.0001) but significantly lower ALT (56 ± 11 vs 97 ± 12 units/Iiter, P = 0.03) levels when compared to the immunocompetent ones. In summary, we found no correlation between serum HCV RNA and ALT levels in chronic hepatitis C patients who are not receiving interferon therapy. Immunosuppression results in higher HCV RNA but lower ALT levels.
Persistent Identifierhttp://hdl.handle.net/10722/162127
ISSN
2015 Impact Factor: 2.516
2015 SCImago Journal Rankings: 0.995
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGhany, MGen_US
dc.contributor.authorChan, TMen_US
dc.contributor.authorSanchezPescador, Ren_US
dc.contributor.authorUrdea, Men_US
dc.contributor.authorLok, ASFen_US
dc.date.accessioned2012-09-05T05:17:30Z-
dc.date.available2012-09-05T05:17:30Z-
dc.date.issued1996en_US
dc.identifier.citationDigestive Diseases And Sciences, 1996, v. 41 n. 11, p. 2213-2218en_US
dc.identifier.issn0163-2116en_US
dc.identifier.urihttp://hdl.handle.net/10722/162127-
dc.description.abstractCross-sectional studies on the correlation between serum hepatitis C virus (HCV) RNA and alanine aminotransferase (ALT) levels in patients with chronic hepatitis C have yielded conflicting results. We conducted a longitudinal study to examine the correlation between HCV viremia and serum ALT levels in individual patients over time. Serial samples (mean 9) from 25 patients with chronic HCV infection, including interferon-treated and untreated immunocompetent and immunosuppressed patients, collected over a period of 1-4.8 years (mean 2.6 years) were tested for HCV RNA and ALT levels using a highly reproducible quantitative (bDNA) assay. A significant correlation was found between serum HCV RNA and ALT levels in the patients who received IFN therapy, but no correlation was observed in the untreated patients. Among the untreated patients, the immunosuppressed patients had significantly higher HCV RNA levels (39 ± 4 vs 3.6 ± 8 Meq/ml, P < 0.0001) but significantly lower ALT (56 ± 11 vs 97 ± 12 units/Iiter, P = 0.03) levels when compared to the immunocompetent ones. In summary, we found no correlation between serum HCV RNA and ALT levels in chronic hepatitis C patients who are not receiving interferon therapy. Immunosuppression results in higher HCV RNA but lower ALT levels.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116en_US
dc.relation.ispartofDigestive Diseases and Sciencesen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAlanine Transaminase - Blooden_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis C - Enzymology - Genetics - Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmune Toleranceen_US
dc.subject.meshInterferons - Therapeutic Useen_US
dc.subject.meshKidney Transplantationen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRna, Viral - Blooden_US
dc.subject.meshRisk Factorsen_US
dc.titleCorrelation between serum HCV RNA and aminotransferase levels in patients with chronic HCV infectionen_US
dc.typeArticleen_US
dc.identifier.emailChan, TM:dtmchan@hku.hken_US
dc.identifier.authorityChan, TM=rp00394en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF02071402-
dc.identifier.pmid8943974-
dc.identifier.scopuseid_2-s2.0-0029826316en_US
dc.identifier.hkuros23603-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029826316&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume41en_US
dc.identifier.issue11en_US
dc.identifier.spage2213en_US
dc.identifier.epage2218en_US
dc.identifier.isiWOS:A1996VU83700014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGhany, MG=6701540425en_US
dc.identifier.scopusauthoridChan, TM=7402687700en_US
dc.identifier.scopusauthoridSanchezPescador, R=6701558204en_US
dc.identifier.scopusauthoridUrdea, M=7005511490en_US
dc.identifier.scopusauthoridLok, ASF=35379868500en_US

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