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Article: Treatment of fungal peritonitis complicating continuous ambulatory peritoneal dialysis with oral fluconazole: A series of 21 patients

TitleTreatment of fungal peritonitis complicating continuous ambulatory peritoneal dialysis with oral fluconazole: A series of 21 patients
Authors
Issue Date1994
PublisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/
Citation
Nephrology Dialysis Transplantation, 1994, v. 9 n. 5, p. 539-542 How to Cite?
AbstractTwenty-one episodes of fungal peritonitis occurred over 35 months among 290 patients on CAPD, accounting for 6.3% of all peritonitis episodes. Patients with more frequent bacterial peritonitis were at higher risk of developing fungal peritonitis, and 28.6% of cases followed antimicrobial therapy. Candida species accounted for 85.7% of cases. Oral fluconazole was used as initial therapy in all patients, which was followed by catheter removal if peritonitis failed to improve. The cure rate with fluconazole therapy alone without catheter removal was 9.5%. Fluconazole plus catheter removal, the latter necessitated in 85.7% of cases, resulted in a cure rate of 66.7%. The remaining 3 (14.3%) patients responded to intravenous amphotericin given as salvage therapy. Disease-related mortality was 14.3%. Reinsertion of dialysis catheter was attempted in 15 patients and CAPD was successfully resumed in 13 (86.7%). We conclude that oral fluconazole can be safely used as initial therapy in patients with fungal peritonitis complicating CAPD. Although catheter removal was necessary in the majority of patients, this sequential approach resulted in a relatively low prevalence of peritoneal adhesions and subsequent CAPD failure.
Persistent Identifierhttp://hdl.handle.net/10722/162053
ISSN
2015 Impact Factor: 4.085
2015 SCImago Journal Rankings: 1.780
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, TMen_US
dc.contributor.authorChan, CYen_US
dc.contributor.authorCheng, SWen_US
dc.contributor.authorLo, WKen_US
dc.contributor.authorLo, CYen_US
dc.contributor.authorCheng, IKPen_US
dc.date.accessioned2012-09-05T05:16:55Z-
dc.date.available2012-09-05T05:16:55Z-
dc.date.issued1994en_US
dc.identifier.citationNephrology Dialysis Transplantation, 1994, v. 9 n. 5, p. 539-542en_US
dc.identifier.issn0931-0509en_US
dc.identifier.urihttp://hdl.handle.net/10722/162053-
dc.description.abstractTwenty-one episodes of fungal peritonitis occurred over 35 months among 290 patients on CAPD, accounting for 6.3% of all peritonitis episodes. Patients with more frequent bacterial peritonitis were at higher risk of developing fungal peritonitis, and 28.6% of cases followed antimicrobial therapy. Candida species accounted for 85.7% of cases. Oral fluconazole was used as initial therapy in all patients, which was followed by catheter removal if peritonitis failed to improve. The cure rate with fluconazole therapy alone without catheter removal was 9.5%. Fluconazole plus catheter removal, the latter necessitated in 85.7% of cases, resulted in a cure rate of 66.7%. The remaining 3 (14.3%) patients responded to intravenous amphotericin given as salvage therapy. Disease-related mortality was 14.3%. Reinsertion of dialysis catheter was attempted in 15 patients and CAPD was successfully resumed in 13 (86.7%). We conclude that oral fluconazole can be safely used as initial therapy in patients with fungal peritonitis complicating CAPD. Although catheter removal was necessary in the majority of patients, this sequential approach resulted in a relatively low prevalence of peritoneal adhesions and subsequent CAPD failure.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/en_US
dc.relation.ispartofNephrology Dialysis Transplantationen_US
dc.rightsNephrology, Dialysis, Transplantation. Copyright © Oxford University Press.-
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAmphotericin B - Therapeutic Useen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluconazole - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshInjections, Intravenousen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMycoses - Drug Therapy - Etiologyen_US
dc.subject.meshPeritoneal Dialysis, Continuous Ambulatory - Adverse Effectsen_US
dc.subject.meshPeritonitis - Drug Therapy - Microbiologyen_US
dc.titleTreatment of fungal peritonitis complicating continuous ambulatory peritoneal dialysis with oral fluconazole: A series of 21 patientsen_US
dc.typeArticleen_US
dc.identifier.emailChan, TM:dtmchan@hku.hken_US
dc.identifier.authorityChan, TM=rp00394en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8090334-
dc.identifier.scopuseid_2-s2.0-0028343346en_US
dc.identifier.hkuros5585-
dc.identifier.volume9en_US
dc.identifier.issue5en_US
dc.identifier.spage539en_US
dc.identifier.epage542en_US
dc.identifier.isiWOS:A1994NQ54800015-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChan, TM=7402687700en_US
dc.identifier.scopusauthoridChan, CY=24517697500en_US
dc.identifier.scopusauthoridCheng, SW=7404684783en_US
dc.identifier.scopusauthoridLo, WK=7201502414en_US
dc.identifier.scopusauthoridLo, CY=7401771743en_US
dc.identifier.scopusauthoridCheng, IKP=7102537483en_US

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