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Article: Decreased bone mineral density in premenopausal asthma patients receiving long-term inhaled steroids

TitleDecreased bone mineral density in premenopausal asthma patients receiving long-term inhaled steroids
Authors
Issue Date1994
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
Citation
Chest, 1994, v. 105 n. 6, p. 1722-1727 How to Cite?
AbstractInhaled corticosteroids have become a key element in the maintenance treatment of bronchial asthma. It is well-known that long-term systemic steroid use causes osteoporosis, whereas its inhaled counterpart has been believed to be devoid of such a side-effect. However, recent studies showed that administration of inhaled corticosteroids was associated with biochemical evidence of derangement in bone turnover. We therefore studied bone mineral density (BMD) by dual energy x-ray absorptiometry in 30 patients (18 females, 12 males) with bronchial asthma treated with steroids, essentially by the inhaled route only (both nasal and tracheobronchial), and compared them with healthy subjects individually matched for age, sex, menopausal status, and body mass index (BMI). There was a significant decrease in BMD in the patient group at the hip (neck of femur, p = 0.007; trochanter of femur, p = 0.034; Ward's triangle, p = 0.016) and the lumbar area of the spine (L2-4, p = 0.041). Further analysis showed that this difference from control subjects was mainly seen in the female patients and not in the male patients (neck of femur, p = 0.049; Ward's triangle, p = 0.025; lumbar spine, p = 0.039). In the female patients, there was significant negative correlation of BMD of the lumbar area of the spine and the trochanter of femur with daily inhaled steroid dose and positive correlation of BMD of the trochanter with BMI.
Persistent Identifierhttp://hdl.handle.net/10722/162052
ISSN
2015 Impact Factor: 5.94
2015 SCImago Journal Rankings: 3.176
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorIp, Men_US
dc.contributor.authorLam, Ken_US
dc.contributor.authorYam, Len_US
dc.contributor.authorKung, Aen_US
dc.contributor.authorNg, Men_US
dc.date.accessioned2012-09-05T05:16:55Z-
dc.date.available2012-09-05T05:16:55Z-
dc.date.issued1994en_US
dc.identifier.citationChest, 1994, v. 105 n. 6, p. 1722-1727en_US
dc.identifier.issn0012-3692en_US
dc.identifier.urihttp://hdl.handle.net/10722/162052-
dc.description.abstractInhaled corticosteroids have become a key element in the maintenance treatment of bronchial asthma. It is well-known that long-term systemic steroid use causes osteoporosis, whereas its inhaled counterpart has been believed to be devoid of such a side-effect. However, recent studies showed that administration of inhaled corticosteroids was associated with biochemical evidence of derangement in bone turnover. We therefore studied bone mineral density (BMD) by dual energy x-ray absorptiometry in 30 patients (18 females, 12 males) with bronchial asthma treated with steroids, essentially by the inhaled route only (both nasal and tracheobronchial), and compared them with healthy subjects individually matched for age, sex, menopausal status, and body mass index (BMI). There was a significant decrease in BMD in the patient group at the hip (neck of femur, p = 0.007; trochanter of femur, p = 0.034; Ward's triangle, p = 0.016) and the lumbar area of the spine (L2-4, p = 0.041). Further analysis showed that this difference from control subjects was mainly seen in the female patients and not in the male patients (neck of femur, p = 0.049; Ward's triangle, p = 0.025; lumbar spine, p = 0.039). In the female patients, there was significant negative correlation of BMD of the lumbar area of the spine and the trochanter of femur with daily inhaled steroid dose and positive correlation of BMD of the trochanter with BMI.en_US
dc.languageengen_US
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.orgen_US
dc.relation.ispartofChesten_US
dc.subject.meshAbsorptiometry, Photonen_US
dc.subject.meshAdministration, Inhalationen_US
dc.subject.meshAdulten_US
dc.subject.meshAerosolsen_US
dc.subject.meshAsthma - Drug Therapyen_US
dc.subject.meshBeclomethasone - Administration & Dosage - Adverse Effectsen_US
dc.subject.meshBone Density - Drug Effectsen_US
dc.subject.meshBronchodilator Agents - Administration & Dosage - Adverse Effectsen_US
dc.subject.meshBudesonideen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshOsteoporosis - Chemically Induceden_US
dc.subject.meshPregnenediones - Administration & Dosage - Adverse Effectsen_US
dc.subject.meshPremenopauseen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshTime Factorsen_US
dc.titleDecreased bone mineral density in premenopausal asthma patients receiving long-term inhaled steroidsen_US
dc.typeArticleen_US
dc.identifier.emailIp, M:msmip@hku.hken_US
dc.identifier.emailLam, K:ksllam@hku.hken_US
dc.identifier.emailKung, A:awckung@hku.hken_US
dc.identifier.authorityIp, M=rp00347en_US
dc.identifier.authorityLam, K=rp00343en_US
dc.identifier.authorityKung, A=rp00368en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1378/chest.105.6.1722-
dc.identifier.pmid8205866-
dc.identifier.scopuseid_2-s2.0-0028298144en_US
dc.identifier.volume105en_US
dc.identifier.issue6en_US
dc.identifier.spage1722en_US
dc.identifier.epage1727en_US
dc.identifier.isiWOS:A1994NT06400023-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridIp, M=7102423259en_US
dc.identifier.scopusauthoridLam, K=8082870600en_US
dc.identifier.scopusauthoridYam, L=55296270900en_US
dc.identifier.scopusauthoridKung, A=7102322339en_US
dc.identifier.scopusauthoridNg, M=55151944800en_US

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