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Article: Hepatic expression of interferon-α in chronic hepatitis B virus infection

TitleHepatic expression of interferon-α in chronic hepatitis B virus infection
Authors
Issue Date1994
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
Citation
Digestive Diseases And Sciences, 1994, v. 39 n. 9, p. 2014-2021 How to Cite?
AbstractHepatic expression of interferon-α (IFN-α) was examined by immunohistochemistry in 90 Chinese patients (M/F 67:23, age: 14-69) with a spectrum of hepatitis B virus (HBV)-related chronic liver diseases. Immunoreactive IFN-α was detected in sinusoidal cells in 79 patients (88%) and in mononuclear cells in 59 patients (65.6%). Patients with active liver diseases (chronic active hepatitis, active cirrhosis, N = 55) had a higher level of IFN-α expression compared to patients with inactive histology (N = 35; sinusoidal cells, P < 0.01; mononuclear cells, P < 0.01). Cytoplasmic HBsAg, nuclear HBcAg, and cytoplasmic HBcAg were detected in 79 (88%), 42 (47%), and 23 (27%) patients respectively. Expression of IFN-α in mononuclear cells correlated with the expression of cytoplasmic HBcAg (P < 0.05) but not with nuclear HBcAg or cytoplasmic HBsAg. When the patients were divided into four different phases according to the natural history of chronic HBV infection, patients in the active liver disease phase had higher IFN-α expression compared to the immunotolerant and late phase patients (P < 0.01). Using double immunohistochemical staining, both IFN-α and cytoplasmic HBcAg were frequently detected near inflammatory infiltrates but no correlation existed between the hepatic expression of HBsAg and IFN-α. These data indicate that IFN-α is expressed in the liver in HBV-related active liver diseases and that the reported suboptimal production of IFN-α by PBMC in HBV-related chronic active liver diseases may be due to a redistribution of the IFN-α-producing mononuclear cells into the liver, the site of inflammation.
Persistent Identifierhttp://hdl.handle.net/10722/162038
ISSN
2015 Impact Factor: 2.516
2015 SCImago Journal Rankings: 0.995
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFang, JWSen_US
dc.contributor.authorWu, PCen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorLo, CKen_US
dc.contributor.authorMeager, Aen_US
dc.contributor.authorLau, JYN-
dc.date.accessioned2012-09-05T05:16:49Z-
dc.date.available2012-09-05T05:16:49Z-
dc.date.issued1994en_US
dc.identifier.citationDigestive Diseases And Sciences, 1994, v. 39 n. 9, p. 2014-2021en_US
dc.identifier.issn0163-2116en_US
dc.identifier.urihttp://hdl.handle.net/10722/162038-
dc.description.abstractHepatic expression of interferon-α (IFN-α) was examined by immunohistochemistry in 90 Chinese patients (M/F 67:23, age: 14-69) with a spectrum of hepatitis B virus (HBV)-related chronic liver diseases. Immunoreactive IFN-α was detected in sinusoidal cells in 79 patients (88%) and in mononuclear cells in 59 patients (65.6%). Patients with active liver diseases (chronic active hepatitis, active cirrhosis, N = 55) had a higher level of IFN-α expression compared to patients with inactive histology (N = 35; sinusoidal cells, P < 0.01; mononuclear cells, P < 0.01). Cytoplasmic HBsAg, nuclear HBcAg, and cytoplasmic HBcAg were detected in 79 (88%), 42 (47%), and 23 (27%) patients respectively. Expression of IFN-α in mononuclear cells correlated with the expression of cytoplasmic HBcAg (P < 0.05) but not with nuclear HBcAg or cytoplasmic HBsAg. When the patients were divided into four different phases according to the natural history of chronic HBV infection, patients in the active liver disease phase had higher IFN-α expression compared to the immunotolerant and late phase patients (P < 0.01). Using double immunohistochemical staining, both IFN-α and cytoplasmic HBcAg were frequently detected near inflammatory infiltrates but no correlation existed between the hepatic expression of HBsAg and IFN-α. These data indicate that IFN-α is expressed in the liver in HBV-related active liver diseases and that the reported suboptimal production of IFN-α by PBMC in HBV-related chronic active liver diseases may be due to a redistribution of the IFN-α-producing mononuclear cells into the liver, the site of inflammation.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116en_US
dc.relation.ispartofDigestive Diseases and Sciencesen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshCytoplasm - Chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B - Ethnology - Pathologyen_US
dc.subject.meshHepatitis B Antigens - Analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshInterferon-Alpha - Analysisen_US
dc.subject.meshInterferon-Gamma - Analysisen_US
dc.subject.meshLiver - Chemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSensitivity And Specificityen_US
dc.titleHepatic expression of interferon-α in chronic hepatitis B virus infectionen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF02088140en_US
dc.identifier.pmid8082512-
dc.identifier.scopuseid_2-s2.0-0028169198en_US
dc.identifier.hkuros5150-
dc.identifier.volume39en_US
dc.identifier.issue9en_US
dc.identifier.spage2014en_US
dc.identifier.epage2021en_US
dc.identifier.isiWOS:A1994PJ30800029-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridFang, JWS=7402963750en_US
dc.identifier.scopusauthoridWu, PC=7403119323en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridMeager, A=7007068182en_US
dc.identifier.scopusauthoridLau, JYN=7402446047en_US

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