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Article: The variability of the hepatitis B virus genome: Statistical analysis and biological implications

TitleThe variability of the hepatitis B virus genome: Statistical analysis and biological implications
Authors
Issue Date1993
PublisherOxford University Press. The Journal's web site is located at http://mbe.oxfordjournals.org/
Citation
Molecular Biology And Evolution, 1993, v. 10 n. 2, p. 457-470 How to Cite?
AbstractA statistical analysis of the nucleotide sequence variability in 14 published hepatitis B virus (HBV) genomes was carried out using parametric and nonparametric methods. A parametric statistical model revealed that the different regions of the genome differed significantly in their variability. The conclusion was supported by a nonparametric kernel-density model of the HBV genome. Genes S, C, and P, region X, the precore region, and the pre- S2/pre-S1 regions were ranked in order of increasing variability. In many instances, conserved regions of the genome identified with sequences of known function in HBV biology. However, other characterized regions (such as pre- S) showed much variability despite the involvement of their encoded peptides in specific functions. Point mutations that may result in the formation of stop codons and amino acid changes may affect the clinical picture of HBV infection and may be reflected in atypical serological patterns.
Persistent Identifierhttp://hdl.handle.net/10722/162000
ISSN
2015 Impact Factor: 13.649
2015 SCImago Journal Rankings: 8.168
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLauder, IJen_US
dc.contributor.authorLin, HJen_US
dc.contributor.authorLau, JYNen_US
dc.contributor.authorSiu, TSen_US
dc.contributor.authorLai, CLen_US
dc.date.accessioned2012-09-05T05:16:33Z-
dc.date.available2012-09-05T05:16:33Z-
dc.date.issued1993en_US
dc.identifier.citationMolecular Biology And Evolution, 1993, v. 10 n. 2, p. 457-470en_US
dc.identifier.issn0737-4038en_US
dc.identifier.urihttp://hdl.handle.net/10722/162000-
dc.description.abstractA statistical analysis of the nucleotide sequence variability in 14 published hepatitis B virus (HBV) genomes was carried out using parametric and nonparametric methods. A parametric statistical model revealed that the different regions of the genome differed significantly in their variability. The conclusion was supported by a nonparametric kernel-density model of the HBV genome. Genes S, C, and P, region X, the precore region, and the pre- S2/pre-S1 regions were ranked in order of increasing variability. In many instances, conserved regions of the genome identified with sequences of known function in HBV biology. However, other characterized regions (such as pre- S) showed much variability despite the involvement of their encoded peptides in specific functions. Point mutations that may result in the formation of stop codons and amino acid changes may affect the clinical picture of HBV infection and may be reflected in atypical serological patterns.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://mbe.oxfordjournals.org/en_US
dc.relation.ispartofMolecular Biology and Evolutionen_US
dc.subject.meshConsensus Sequenceen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshGenome, Viralen_US
dc.subject.meshHepatitis B Virus - Geneticsen_US
dc.subject.meshLikelihood Functionsen_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshMutationen_US
dc.subject.meshSequence Alignmenten_US
dc.titleThe variability of the hepatitis B virus genome: Statistical analysis and biological implicationsen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8487640-
dc.identifier.scopuseid_2-s2.0-0027460836en_US
dc.identifier.volume10en_US
dc.identifier.issue2en_US
dc.identifier.spage457en_US
dc.identifier.epage470en_US
dc.identifier.isiWOS:A1993KT91100016-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLauder, IJ=35564928000en_US
dc.identifier.scopusauthoridLin, HJ=7405568624en_US
dc.identifier.scopusauthoridLau, JYN=7402446047en_US
dc.identifier.scopusauthoridSiu, TS=36781548600en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US

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