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Article: OKT3-induced acute pulmonary edema in a euvolemic patient despite premedication with methylprednisolone and antithymocyte globulin

TitleOKT3-induced acute pulmonary edema in a euvolemic patient despite premedication with methylprednisolone and antithymocyte globulin
Authors
KeywordsAcute Pulmonary Edema
First-Dose Reaction
Okt3
Issue Date1993
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTR
Citation
Clinical Transplantation, 1993, v. 7 n. 2, p. 195-198 How to Cite?
AbstractAcute pulmonary edema is a well-recognized complication after the first dose of OKT3 therapy in patients with fluid overload. The first-dose effect is thought to be related to the action of cytokines, namely tumor necrosis factor-alpha (TNF-α), interleukin 2 (IL-2) and interferon gamma (IF-γ), which are released from activated T lymphocytes. Premedications such as high-dose methylprednisolone (MP) and more recently antithymocyte globulin (ATG) has been shown to alleviate the severity of the first-dose effect by reducing the level of cytokines released. We hereby report a euvolemic patient who developed acute pulmonary edema 5 hours after OKT3 therapy despite premedications with high-dose MP and ATG.
Persistent Identifierhttp://hdl.handle.net/10722/161981
ISSN
2015 Impact Factor: 1.844
2015 SCImago Journal Rankings: 0.821

 

DC FieldValueLanguage
dc.contributor.authorLo, CYen_US
dc.contributor.authorChan, TMen_US
dc.contributor.authorLo, WKen_US
dc.contributor.authorCheng, IKPen_US
dc.date.accessioned2012-09-05T05:16:27Z-
dc.date.available2012-09-05T05:16:27Z-
dc.date.issued1993en_US
dc.identifier.citationClinical Transplantation, 1993, v. 7 n. 2, p. 195-198en_US
dc.identifier.issn0902-0063en_US
dc.identifier.urihttp://hdl.handle.net/10722/161981-
dc.description.abstractAcute pulmonary edema is a well-recognized complication after the first dose of OKT3 therapy in patients with fluid overload. The first-dose effect is thought to be related to the action of cytokines, namely tumor necrosis factor-alpha (TNF-α), interleukin 2 (IL-2) and interferon gamma (IF-γ), which are released from activated T lymphocytes. Premedications such as high-dose methylprednisolone (MP) and more recently antithymocyte globulin (ATG) has been shown to alleviate the severity of the first-dose effect by reducing the level of cytokines released. We hereby report a euvolemic patient who developed acute pulmonary edema 5 hours after OKT3 therapy despite premedications with high-dose MP and ATG.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTRen_US
dc.relation.ispartofClinical Transplantationen_US
dc.subjectAcute Pulmonary Edemaen_US
dc.subjectFirst-Dose Reactionen_US
dc.subjectOkt3en_US
dc.titleOKT3-induced acute pulmonary edema in a euvolemic patient despite premedication with methylprednisolone and antithymocyte globulinen_US
dc.typeArticleen_US
dc.identifier.emailChan, TM:dtmchan@hku.hken_US
dc.identifier.authorityChan, TM=rp00394en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0027319488en_US
dc.identifier.volume7en_US
dc.identifier.issue2en_US
dc.identifier.spage195en_US
dc.identifier.epage198en_US
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridLo, CY=7401771743en_US
dc.identifier.scopusauthoridChan, TM=7402687700en_US
dc.identifier.scopusauthoridLo, WK=7201502414en_US
dc.identifier.scopusauthoridCheng, IKP=7102537483en_US

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