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Article: Relationship between intrahepatic expression of hepatitis B viral antigens and histology in Chinese patients with chronic hepatitis B virus infection

TitleRelationship between intrahepatic expression of hepatitis B viral antigens and histology in Chinese patients with chronic hepatitis B virus infection
Authors
Issue Date1993
PublisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com
Citation
American Journal Of Clinical Pathology, 1993, v. 100 n. 6, p. 648-653 How to Cite?
AbstractHepatic cellular and subcellular expression of hepatitis B virus (HBV) antigens-HBsAg, HBcAg, and HBeAg-in 143 Chinese patients with chronic HBV infection were studied by immunohistochemical techniques. Nuclear expression of HBcAg and nuclear and cytoplasmic expression of HBeAg showed a secular trend decreasing from the carrier state and chronic persistent hepatitis (CPH), through chronic active hepatitis (CAH), to cirrhosis with or without hepatocellular carcinoma. In contrast, cytoplasmic HBcAg expression was significantly greater in patients with CPH and CAH (P < .0108). In addition, cytoplasmic HBcAg correlated significantly with lobular activity, portal inflammation, and hepatitic activity (P ≤ .007). Expression of cytoplasmic HBcAg also exceeded cytoplasmic HBeAg and nuclear HBcAg in liver specimens showing significant damage (P < .038). HBsAg, however, showed no secular trend and was not related to liver histology. The authors' findings support the theory that HBcAg is also the viral target antigen for immune-mediated liver damage in Chinese patients with chronic HBV infection.
Persistent Identifierhttp://hdl.handle.net/10722/161960
ISSN
2015 Impact Factor: 2.278
2015 SCImago Journal Rankings: 1.129
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, PCen_US
dc.contributor.authorLau, JYNen_US
dc.contributor.authorLau, TKen_US
dc.contributor.authorLau, SKen_US
dc.contributor.authorLai, CLen_US
dc.date.accessioned2012-09-05T05:16:19Z-
dc.date.available2012-09-05T05:16:19Z-
dc.date.issued1993en_US
dc.identifier.citationAmerican Journal Of Clinical Pathology, 1993, v. 100 n. 6, p. 648-653en_US
dc.identifier.issn0002-9173en_US
dc.identifier.urihttp://hdl.handle.net/10722/161960-
dc.description.abstractHepatic cellular and subcellular expression of hepatitis B virus (HBV) antigens-HBsAg, HBcAg, and HBeAg-in 143 Chinese patients with chronic HBV infection were studied by immunohistochemical techniques. Nuclear expression of HBcAg and nuclear and cytoplasmic expression of HBeAg showed a secular trend decreasing from the carrier state and chronic persistent hepatitis (CPH), through chronic active hepatitis (CAH), to cirrhosis with or without hepatocellular carcinoma. In contrast, cytoplasmic HBcAg expression was significantly greater in patients with CPH and CAH (P < .0108). In addition, cytoplasmic HBcAg correlated significantly with lobular activity, portal inflammation, and hepatitic activity (P ≤ .007). Expression of cytoplasmic HBcAg also exceeded cytoplasmic HBeAg and nuclear HBcAg in liver specimens showing significant damage (P < .038). HBsAg, however, showed no secular trend and was not related to liver histology. The authors' findings support the theory that HBcAg is also the viral target antigen for immune-mediated liver damage in Chinese patients with chronic HBV infection.en_US
dc.languageengen_US
dc.publisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.comen_US
dc.relation.ispartofAmerican Journal of Clinical Pathologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarrier Stateen_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B - Ethnology - Immunology - Pathologyen_US
dc.subject.meshHepatitis B Antigens - Analysisen_US
dc.subject.meshHepatitis B Core Antigens - Analysisen_US
dc.subject.meshHepatitis B Surface Antigens - Analysisen_US
dc.subject.meshHepatitis B E Antigens - Analysisen_US
dc.subject.meshHepatitis, Chronic - Ethnology - Immunology - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshLiver - Immunology - Pathologyen_US
dc.subject.meshLiver Diseases - Ethnology - Immunology - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSubcellular Fractions - Immunologyen_US
dc.titleRelationship between intrahepatic expression of hepatitis B viral antigens and histology in Chinese patients with chronic hepatitis B virus infectionen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8249912-
dc.identifier.scopuseid_2-s2.0-0027131448en_US
dc.identifier.volume100en_US
dc.identifier.issue6en_US
dc.identifier.spage648en_US
dc.identifier.epage653en_US
dc.identifier.isiWOS:A1993ML60400011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWu, PC=7403119323en_US
dc.identifier.scopusauthoridLau, JYN=7402446047en_US
dc.identifier.scopusauthoridLau, TK=35979170400en_US
dc.identifier.scopusauthoridLau, SK=55041328500en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US

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