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Article: Subclinical hepatocellular carcinoma in Hong Kong Chinese

TitleSubclinical hepatocellular carcinoma in Hong Kong Chinese
Authors
KeywordsFetoprotein screening
Hepatocellular carcinoma
Hepatocellular carcinoma, subclinical
Issue Date1992
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/OCL
Citation
Oncology, 1992, v. 49 n. 5, p. 347-353 How to Cite?
AbstractOf the 208 Chinese patients with histologically proven hepatocellular carcinoma (HCC) seen during a 5-year period, 191 patients presented with symptomatic HCC and 17 patients with asymptomatic HCC (subclinical HCC, SCHCC) being picked up by α-fetoprotein (AFP) screening. Compared with the patients with symptomatic HCC, patients with SCHCC had a better performance status (p < 0.01), higher serum albumin levels (p < 0.05) and lower alkaline phosphatase levels (p < 0.01). In those patients with symptomatic HCC, 4.7% were operable and only 2 patients had a tumour diameter of less than 5 cm. In contrast, patients with SCHCC had a higher operability rate (76.5%, p < 0.0001) and all had a tumour of less than 5 cm in diameter (p < 0.0001). Patients with SCHCC, most of whom had their tumour resected, had a better long-term survival (p < 0.0001). We conclude that patients with SCHCC picked up by AFP serosurveillance have a better performance status, higher operability and better prognosis.
Persistent Identifierhttp://hdl.handle.net/10722/161937
ISSN
2015 Impact Factor: 2.152
2015 SCImago Journal Rankings: 0.920
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, CLen_HK
dc.contributor.authorLau, JYNen_HK
dc.contributor.authorWu, PCen_HK
dc.contributor.authorHui, WMen_HK
dc.contributor.authorLai, ECSen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorNgan, Hen_HK
dc.contributor.authorLin, HJen_HK
dc.date.accessioned2012-09-05T05:16:09Z-
dc.date.available2012-09-05T05:16:09Z-
dc.date.issued1992en_HK
dc.identifier.citationOncology, 1992, v. 49 n. 5, p. 347-353en_HK
dc.identifier.issn0030-2414en_HK
dc.identifier.urihttp://hdl.handle.net/10722/161937-
dc.description.abstractOf the 208 Chinese patients with histologically proven hepatocellular carcinoma (HCC) seen during a 5-year period, 191 patients presented with symptomatic HCC and 17 patients with asymptomatic HCC (subclinical HCC, SCHCC) being picked up by α-fetoprotein (AFP) screening. Compared with the patients with symptomatic HCC, patients with SCHCC had a better performance status (p < 0.01), higher serum albumin levels (p < 0.05) and lower alkaline phosphatase levels (p < 0.01). In those patients with symptomatic HCC, 4.7% were operable and only 2 patients had a tumour diameter of less than 5 cm. In contrast, patients with SCHCC had a higher operability rate (76.5%, p < 0.0001) and all had a tumour of less than 5 cm in diameter (p < 0.0001). Patients with SCHCC, most of whom had their tumour resected, had a better long-term survival (p < 0.0001). We conclude that patients with SCHCC picked up by AFP serosurveillance have a better performance status, higher operability and better prognosis.en_HK
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/OCLen_HK
dc.relation.ispartofOncologyen_HK
dc.subjectFetoprotein screeningen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectHepatocellular carcinoma, subclinicalen_HK
dc.subject.meshActuarial Analysisen_US
dc.subject.meshCarcinoma, Hepatocellular - Diagnosis - Epidemiology - Surgeryen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHepatitis B - Complicationsen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Cirrhosis - Complicationsen_US
dc.subject.meshLiver Neoplasms - Diagnosis - Epidemiology - Surgeryen_US
dc.subject.meshSurvival Analysisen_US
dc.subject.meshAlpha-Fetoproteins - Analysisen_US
dc.titleSubclinical hepatocellular carcinoma in Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000227071-
dc.identifier.pmid1382257en_HK
dc.identifier.scopuseid_2-s2.0-0026648970en_HK
dc.identifier.volume49en_HK
dc.identifier.issue5en_HK
dc.identifier.spage347en_HK
dc.identifier.epage353en_HK
dc.identifier.isiWOS:A1992JQ73000007-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridLau, JYN=7402446047en_HK
dc.identifier.scopusauthoridWu, PC=7403119323en_HK
dc.identifier.scopusauthoridHui, WM=7103196477en_HK
dc.identifier.scopusauthoridLai, ECS=7201466530en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridNgan, H=7102173824en_HK
dc.identifier.scopusauthoridLin, HJ=7405571707en_HK

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