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Article: Precore sequence variation in Chinese isolates of hepatitis B virus

TitlePrecore sequence variation in Chinese isolates of hepatitis B virus
Authors
Issue Date1992
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 1992, v. 165 n. 1, p. 127-133 How to Cite?
AbstractDirect sequencing of polymerase chain reaction-amplified serum hepatitis B virus (HBV) DNA was used to characterize the precore region of HBV from Chinese patients with chronic hepatitis. Two types of mutually exclusive variants were found in hepatitis B e antigen (HBeAg)-negative patients. The first (M1) contains a substitution from proline to serine at codon 15. A second group were infected with a previously described mutant (M2) containing a translational stop codon. HBeAg-positive patients were infected with the wild-type virus or the M1-containing strain. M2 emerged in patients with wild-type infection after seroconversion to anti-HBe, whereas M1 was present during the HBeAg-positive phase. In those with fluctuating HBe status, there was no correlation between prevailing HBe serology and sequence. There was an association between infection with variants and severe chronic hepatitis. Patients infected with strains containing M1 while HBeAg positive had a worse prognosis after seroconversion to anti-HBe.
Persistent Identifierhttp://hdl.handle.net/10722/161933
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCarman, WFen_US
dc.contributor.authorFerrao, Men_US
dc.contributor.authorLok, ASFen_US
dc.contributor.authorMa, OCKen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorThomas, HCen_US
dc.date.accessioned2012-09-05T05:16:08Z-
dc.date.available2012-09-05T05:16:08Z-
dc.date.issued1992en_US
dc.identifier.citationJournal Of Infectious Diseases, 1992, v. 165 n. 1, p. 127-133en_US
dc.identifier.issn0022-1899en_US
dc.identifier.urihttp://hdl.handle.net/10722/161933-
dc.description.abstractDirect sequencing of polymerase chain reaction-amplified serum hepatitis B virus (HBV) DNA was used to characterize the precore region of HBV from Chinese patients with chronic hepatitis. Two types of mutually exclusive variants were found in hepatitis B e antigen (HBeAg)-negative patients. The first (M1) contains a substitution from proline to serine at codon 15. A second group were infected with a previously described mutant (M2) containing a translational stop codon. HBeAg-positive patients were infected with the wild-type virus or the M1-containing strain. M2 emerged in patients with wild-type infection after seroconversion to anti-HBe, whereas M1 was present during the HBeAg-positive phase. In those with fluctuating HBe status, there was no correlation between prevailing HBe serology and sequence. There was an association between infection with variants and severe chronic hepatitis. Patients infected with strains containing M1 while HBeAg positive had a worse prognosis after seroconversion to anti-HBe.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.orgen_US
dc.relation.ispartofJournal of Infectious Diseasesen_US
dc.subject.meshAlanine Transaminase - Blooden_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshDna, Viral - Chemistryen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshHepatitis B - Microbiologyen_US
dc.subject.meshHepatitis B E Antigens - Blooden_US
dc.subject.meshHepatitis B Virus - Geneticsen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshMutationen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshViremia - Microbiologyen_US
dc.titlePrecore sequence variation in Chinese isolates of hepatitis B virusen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/infdis/165.1.127-
dc.identifier.pmid1727881-
dc.identifier.scopuseid_2-s2.0-0026599114en_US
dc.identifier.volume165en_US
dc.identifier.issue1en_US
dc.identifier.spage127en_US
dc.identifier.epage133en_US
dc.identifier.isiWOS:A1992GW58200017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCarman, WF=7004473265en_US
dc.identifier.scopusauthoridFerrao, M=6602175690en_US
dc.identifier.scopusauthoridLok, ASF=35379868500en_US
dc.identifier.scopusauthoridMa, OCK=7004452841en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridThomas, HC=7403743110en_US

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