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Article: Seroepidemiological survey of hepatitis E in Hong Kong by recombinant-based enzyme immunoassays

TitleSeroepidemiological survey of hepatitis E in Hong Kong by recombinant-based enzyme immunoassays
Authors
Issue Date1992
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
Citation
Lancet, 1992, v. 340 n. 8829, p. 1205-1208 How to Cite?
AbstractThe agent that causes the enterally transmitted form of non-A, non-B hepatitis has been cloned and called hepatitis E virus (HEV). We have carried out a seroepidemiological survey on the prevalence of hepatitis E in Hong Kong. In a retrospective study, serum from 394 patients with acute viral hepatitis and 355 healthy subjects was tested for antibodies to HEV (anti-HEV) with a recombinant based enzyme immunoassay. 65 (16.5%) patients with hepatitis were positive for IgM anti-HEV and 23 (5.8%) were also positive for IgM anti-HEV. Of 18 patients diagnosed as having acute non-A, non-B, non-C hepatitis, 6 were IgM anti-HEV positive. 17 (6%) patients in whom acute hepatitis A was diagnosed were also infected wit HEV. None of 70 patients with acute hepatitis B or C or exacerbation of chronic hepatitis B was IgM anti-HEV positive. 57 (16.1%) of the healthy subjects were positive for IgG anti-HEV. The prevalence of IgG anti-HEV was higher in subjects over 20 years old than in younger subjects (24% vs 4%, p < 0.0001). IgG anti-HEV was detected in 26% of subjects who were positive for IgG antibody to HAV and in 7% of those negative for that antibody (p < 0.0001). We demonstrated the validity of the recombinant-based enzyme immunoassays for the diagnosis of hepatitis E. Our results suggest that hepatitis E accounts for a third of non-A, non-B, non-C hepatitis in Hong Kong and that coinfection of hepatitis A and E can occur.
Persistent Identifierhttp://hdl.handle.net/10722/161917
ISSN
2015 Impact Factor: 44.002
2015 SCImago Journal Rankings: 14.638
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLok, ASFen_US
dc.contributor.authorKwan, WKen_US
dc.contributor.authorMoeckli, Ren_US
dc.contributor.authorYarbough, POen_US
dc.contributor.authorChan, RTen_US
dc.contributor.authorReyes, GRen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorChung, HTen_US
dc.contributor.authorLai, TSTen_US
dc.date.accessioned2012-09-05T05:16:01Z-
dc.date.available2012-09-05T05:16:01Z-
dc.date.issued1992en_US
dc.identifier.citationLancet, 1992, v. 340 n. 8829, p. 1205-1208en_US
dc.identifier.issn0140-6736en_US
dc.identifier.urihttp://hdl.handle.net/10722/161917-
dc.description.abstractThe agent that causes the enterally transmitted form of non-A, non-B hepatitis has been cloned and called hepatitis E virus (HEV). We have carried out a seroepidemiological survey on the prevalence of hepatitis E in Hong Kong. In a retrospective study, serum from 394 patients with acute viral hepatitis and 355 healthy subjects was tested for antibodies to HEV (anti-HEV) with a recombinant based enzyme immunoassay. 65 (16.5%) patients with hepatitis were positive for IgM anti-HEV and 23 (5.8%) were also positive for IgM anti-HEV. Of 18 patients diagnosed as having acute non-A, non-B, non-C hepatitis, 6 were IgM anti-HEV positive. 17 (6%) patients in whom acute hepatitis A was diagnosed were also infected wit HEV. None of 70 patients with acute hepatitis B or C or exacerbation of chronic hepatitis B was IgM anti-HEV positive. 57 (16.1%) of the healthy subjects were positive for IgG anti-HEV. The prevalence of IgG anti-HEV was higher in subjects over 20 years old than in younger subjects (24% vs 4%, p < 0.0001). IgG anti-HEV was detected in 26% of subjects who were positive for IgG antibody to HAV and in 7% of those negative for that antibody (p < 0.0001). We demonstrated the validity of the recombinant-based enzyme immunoassays for the diagnosis of hepatitis E. Our results suggest that hepatitis E accounts for a third of non-A, non-B, non-C hepatitis in Hong Kong and that coinfection of hepatitis A and E can occur.en_US
dc.languageengen_US
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lanceten_US
dc.relation.ispartofLanceten_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis Antibodies - Blooden_US
dc.subject.meshHepatitis E - Diagnosis - Epidemiology - Immunologyen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshLongitudinal Studiesen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRecombinant Proteinsen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSeroepidemiologic Studiesen_US
dc.subject.meshSerologic Tests - Methodsen_US
dc.titleSeroepidemiological survey of hepatitis E in Hong Kong by recombinant-based enzyme immunoassaysen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0140-6736(92)92901-Qen_US
dc.identifier.pmid1359270-
dc.identifier.scopuseid_2-s2.0-0026479880en_US
dc.identifier.volume340en_US
dc.identifier.issue8829en_US
dc.identifier.spage1205en_US
dc.identifier.epage1208en_US
dc.identifier.isiWOS:A1992JY38600013-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLok, ASF=35379868500en_US
dc.identifier.scopusauthoridKwan, WK=7006610871en_US
dc.identifier.scopusauthoridMoeckli, R=6701833320en_US
dc.identifier.scopusauthoridYarbough, PO=6701326436en_US
dc.identifier.scopusauthoridChan, RT=7403110774en_US
dc.identifier.scopusauthoridReyes, GR=7103260522en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridChung, HT=36797189000en_US
dc.identifier.scopusauthoridLai, TST=35559048100en_US

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