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Article: Neutrophils in chronic active hepatitis type B

TitleNeutrophils in chronic active hepatitis type B
Authors
Issue Date1991
Citation
Archives Of Pathology And Laboratory Medicine, 1991, v. 115 n. 9, p. 930-933 How to Cite?
AbstractLiver biopsy specimens from 95 patients with chronic active hepatitis type B were studied to define the incidence of portal tract and/or septal neutrophilic infiltration and its relationship with other morphohistologic factors and with liver function tests. Neutrophils were identified in the portal tracts and fibrous septa in 59 cases (62%), among which 19 cases (20%) showed four or more neutrophils per high-power field. Significant neutrophilic infiltration (>6 per high-power field) was observed in only seven (7.4%) of 95 cases. Multiple-regression analysis revealed that neutrophilic infiltration was significantly associated with marginal duct proliferation, bile duct proliferation, and an elevated alanine aminotransferase level. Applying a partial correlation coefficient, it was shown that neutrophilic infiltration was not related to piecemeal necrosis after controlling for marginal duct proliferation. The findings suggest that in chronic active hepatitis B, while piecemeal necrosis interferes with bile flow at the limiting plate region, marginal duct and bile duct proliferations follow and lead to the accumulation of neutrophils.
Persistent Identifierhttp://hdl.handle.net/10722/161891
ISSN
2015 Impact Factor: 2.631
2015 SCImago Journal Rankings: 1.158
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, PCen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorChoy, Cen_US
dc.date.accessioned2012-09-05T05:15:51Z-
dc.date.available2012-09-05T05:15:51Z-
dc.date.issued1991en_US
dc.identifier.citationArchives Of Pathology And Laboratory Medicine, 1991, v. 115 n. 9, p. 930-933en_US
dc.identifier.issn0003-9985en_US
dc.identifier.urihttp://hdl.handle.net/10722/161891-
dc.description.abstractLiver biopsy specimens from 95 patients with chronic active hepatitis type B were studied to define the incidence of portal tract and/or septal neutrophilic infiltration and its relationship with other morphohistologic factors and with liver function tests. Neutrophils were identified in the portal tracts and fibrous septa in 59 cases (62%), among which 19 cases (20%) showed four or more neutrophils per high-power field. Significant neutrophilic infiltration (>6 per high-power field) was observed in only seven (7.4%) of 95 cases. Multiple-regression analysis revealed that neutrophilic infiltration was significantly associated with marginal duct proliferation, bile duct proliferation, and an elevated alanine aminotransferase level. Applying a partial correlation coefficient, it was shown that neutrophilic infiltration was not related to piecemeal necrosis after controlling for marginal duct proliferation. The findings suggest that in chronic active hepatitis B, while piecemeal necrosis interferes with bile flow at the limiting plate region, marginal duct and bile duct proliferations follow and lead to the accumulation of neutrophils.en_US
dc.languageengen_US
dc.relation.ispartofArchives of Pathology and Laboratory Medicineen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBiopsyen_US
dc.subject.meshCell Movementen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B - Pathology - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeutrophils - Pathology - Physiologyen_US
dc.subject.meshStatistics As Topicen_US
dc.titleNeutrophils in chronic active hepatitis type Ben_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1929789-
dc.identifier.scopuseid_2-s2.0-0026002942en_US
dc.identifier.volume115en_US
dc.identifier.issue9en_US
dc.identifier.spage930en_US
dc.identifier.epage933en_US
dc.identifier.isiWOS:A1991GF52100020-
dc.identifier.scopusauthoridWu, PC=7403119323en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridChoy, C=7202840937en_US

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