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Article: A patient with large granular lymphocytosis of unusual phenotype and polymorphic T-cell receptor beta-chain gene rearrangement

TitleA patient with large granular lymphocytosis of unusual phenotype and polymorphic T-cell receptor beta-chain gene rearrangement
Authors
Lin, CKLiu, HWTse, PWTLai, CLChan, GTC
KeywordsLarge granular lymphocytosis
Polymorphic T-cell receptor Beta-chain gene rearrangement
Issue Date1990
PublisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com
Citation
American Journal Of Clinical Pathology, 1990, v. 94 n. 2, p. 211-216 How to Cite?
DOI: http://dx.doi.org/10.1093/ajcp/94.2.211
AbstractThe authors describe a patient with large granular lymphocytosis who presented with fever of unknown origin and jaundice. Immunophenotyping showed that most of the large granular lymphocytes (LGLs) were CD3-, CD16-, and NKH-1 (Leu-19)+ lymphocytes. Lymphocytosis of this subset of LGLs has not been reported. Analysis of T-cell receptor gene showed polymorphic T-cell receptor beta-chain (TCRβ) gene configuration. Functional studies showed reduced natural killer cell function. The clinical course was very aggressive and resistant to chemotherapy. These features again rise the controversial issues of the ontogeny and heterogeneity of LGLs and their relationship to natural killer cells and T-cells.
Persistent Identifierhttp://hdl.handle.net/10722/161847
ISSN
0002-9173
2023 Impact Factor: 2.3
2023 SCImago Journal Rankings: 0.775
ISI Accession Number ID
WOS:A1990DR25700015

 

DC FieldValueLanguage
dc.contributor.authorLin, CKen_US
dc.contributor.authorLiu, HWen_US
dc.contributor.authorTse, PWTen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorChan, GTCen_US
dc.date.accessioned2012-09-05T05:15:29Z-
dc.date.available2012-09-05T05:15:29Z-
dc.date.issued1990en_US
dc.identifier.citationAmerican Journal Of Clinical Pathology, 1990, v. 94 n. 2, p. 211-216en_US
dc.identifier.issn0002-9173en_US
dc.identifier.urihttp://hdl.handle.net/10722/161847-
dc.description.abstractThe authors describe a patient with large granular lymphocytosis who presented with fever of unknown origin and jaundice. Immunophenotyping showed that most of the large granular lymphocytes (LGLs) were CD3-, CD16-, and NKH-1 (Leu-19)+ lymphocytes. Lymphocytosis of this subset of LGLs has not been reported. Analysis of T-cell receptor gene showed polymorphic T-cell receptor beta-chain (TCRβ) gene configuration. Functional studies showed reduced natural killer cell function. The clinical course was very aggressive and resistant to chemotherapy. These features again rise the controversial issues of the ontogeny and heterogeneity of LGLs and their relationship to natural killer cells and T-cells.en_US
dc.languageengen_US
dc.publisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.comen_US
dc.relation.ispartofAmerican Journal of Clinical Pathologyen_US
dc.subjectLarge granular lymphocytosis-
dc.subjectPolymorphic T-cell receptor Beta-chain gene rearrangement-
dc.subject.meshAdulten_US
dc.subject.meshAntibodies, Monoclonal - Diagnostic Useen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshGene Rearrangement, Beta-Chain T-Cell Antigen Receptoren_US
dc.subject.meshHumansen_US
dc.subject.meshKiller Cells, Natural - Physiologyen_US
dc.subject.meshLymphocytosis - Genetics - Immunology - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMicroscopy, Electronen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshStaining And Labelingen_US
dc.subject.meshT-Lymphocytes - Pathology - Ultrastructureen_US
dc.titleA patient with large granular lymphocytosis of unusual phenotype and polymorphic T-cell receptor beta-chain gene rearrangementen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/ajcp/94.2.211-
dc.identifier.pmid1695480-
dc.identifier.scopuseid_2-s2.0-0025375530en_US
dc.identifier.volume94en_US
dc.identifier.issue2en_US
dc.identifier.spage211en_US
dc.identifier.epage216en_US
dc.identifier.isiWOS:A1990DR25700015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLin, CK=15034856400en_US
dc.identifier.scopusauthoridLiu, HW=36071958800en_US
dc.identifier.scopusauthoridTse, PWT=36952697600en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridChan, GTC=7202355262en_US
dc.identifier.issnl0002-9173-

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