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Article: Circulating somatostatin after oral glucose in hypothyroidism

TitleCirculating somatostatin after oral glucose in hypothyroidism
Authors
Issue Date1990
Citation
Journal Of Endocrinological Investigation, 1990, v. 13 n. 5, p. 403-406 How to Cite?
AbstractThe response of circulating somatostatin-like immunoactivity (SLI) to oral glucose and its relation to other pancreatic islet cell hormones were studied in 10 hypothyroid subjects before and after treatment. None of the patients suffered from diabetes mellitus or obesity. Compared with normal controls, the hypothyroid subjects had higher fasting and stimulated SLI levels but lower fasting pancreatic glucagon levels. Integrated glucose and insulin responses following glucose ingestion were normal, but the peak insulin reponse was delayed to 120 min suggesting impaired pancreatic β-cell response to oral glucose. On the other hand, the peak response of plasma C-peptide was higher probably because of a reduction in metabolic clearance. In both hypothyroid subjects and controls, a significant correlation was found between the maximal increment of SLI and the maximal decrement of glucagon following oral glucose. In conclusion, plasma SLI is increased in hypothyroidism. The changes in SLI may be due to either an increased hormonal secretion or a reduced metabolic clearance in hypothyroidism. This elevated SLI might contribute to the slower gastrointestinal motility observed in hypothyroidism. Our data also suggest that the reduction in glucagon secretion may be secondary to the increase in circulating SLI.
Persistent Identifierhttp://hdl.handle.net/10722/161839
ISSN
2013 Impact Factor: 1.552
2015 SCImago Journal Rankings: 0.675
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKung, AWCen_US
dc.contributor.authorLam, KSLen_US
dc.contributor.authorPun, KKen_US
dc.contributor.authorWang, Cen_US
dc.contributor.authorYeung, RTTen_US
dc.date.accessioned2012-09-05T05:15:25Z-
dc.date.available2012-09-05T05:15:25Z-
dc.date.issued1990en_US
dc.identifier.citationJournal Of Endocrinological Investigation, 1990, v. 13 n. 5, p. 403-406en_US
dc.identifier.issn0391-4097en_US
dc.identifier.urihttp://hdl.handle.net/10722/161839-
dc.description.abstractThe response of circulating somatostatin-like immunoactivity (SLI) to oral glucose and its relation to other pancreatic islet cell hormones were studied in 10 hypothyroid subjects before and after treatment. None of the patients suffered from diabetes mellitus or obesity. Compared with normal controls, the hypothyroid subjects had higher fasting and stimulated SLI levels but lower fasting pancreatic glucagon levels. Integrated glucose and insulin responses following glucose ingestion were normal, but the peak insulin reponse was delayed to 120 min suggesting impaired pancreatic β-cell response to oral glucose. On the other hand, the peak response of plasma C-peptide was higher probably because of a reduction in metabolic clearance. In both hypothyroid subjects and controls, a significant correlation was found between the maximal increment of SLI and the maximal decrement of glucagon following oral glucose. In conclusion, plasma SLI is increased in hypothyroidism. The changes in SLI may be due to either an increased hormonal secretion or a reduced metabolic clearance in hypothyroidism. This elevated SLI might contribute to the slower gastrointestinal motility observed in hypothyroidism. Our data also suggest that the reduction in glucagon secretion may be secondary to the increase in circulating SLI.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Endocrinological Investigationen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshC-Peptide - Blooden_US
dc.subject.meshChinaen_US
dc.subject.meshGlucagon - Blooden_US
dc.subject.meshGlucose - Pharmacologyen_US
dc.subject.meshGlucose Tolerance Testen_US
dc.subject.meshHumansen_US
dc.subject.meshHypothyroidism - Blooden_US
dc.subject.meshInsulin - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSomatostatin - Blooden_US
dc.subject.meshThyrotropin - Blooden_US
dc.subject.meshThyroxine - Analysisen_US
dc.subject.meshTriiodothyronine - Blooden_US
dc.titleCirculating somatostatin after oral glucose in hypothyroidismen_US
dc.typeArticleen_US
dc.identifier.emailKung, AWC:awckung@hku.hken_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.authorityKung, AWC=rp00368en_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF03350690-
dc.identifier.pmid1974268-
dc.identifier.scopuseid_2-s2.0-0025307078en_US
dc.identifier.volume13en_US
dc.identifier.issue5en_US
dc.identifier.spage403en_US
dc.identifier.epage406en_US
dc.identifier.isiWOS:A1990DK93000005-
dc.publisher.placeItalyen_US
dc.identifier.scopusauthoridKung, AWC=7102322339en_US
dc.identifier.scopusauthoridLam, KSL=8082870600en_US
dc.identifier.scopusauthoridPun, KK=7006538877en_US
dc.identifier.scopusauthoridWang, C=7501631357en_US
dc.identifier.scopusauthoridYeung, RTT=7102833337en_US

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