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Article: Wilson's disease: 35 Years' experience

TitleWilson's disease: 35 Years' experience
Authors
Issue Date1990
Citation
Quarterly Journal Of Medicine, 1990, v. 75 n. 278, p. 597-605 How to Cite?
AbstractThirty-seven Chinese patients fulfilling the criteria for Wilson's disease seen during a 35-year period were reviewed. Males and females were equally affected. Twenty-two patients were symptomatic and 15 asymptomatic; most of them presented before the third decade. Thirty-one per cent of the relatives screened showed evidence of disease, and parents were rarely affected (13 per cent). Half of the adult symptomatic females presented with primary amenorrhoea. Liver laboratory test were abnormal in only 50 per cent of patients, with γ-glutamyl-transpeptidase being the most sensitive index. Renal disease was infrequent. Serum caeruloplasmin level was the single biochemical parameter of prognostic significance (p = 0.0001). Seventy per cent of the symptomatic patients showed an improvement after treatment with penicillamine.
Persistent Identifierhttp://hdl.handle.net/10722/161838
ISSN
1998 Impact Factor: 2.244
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, JYNen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorWu, PCen_US
dc.contributor.authorPan, HYMen_US
dc.contributor.authorLin, HJen_US
dc.contributor.authorTodd, Den_US
dc.date.accessioned2012-09-05T05:15:24Z-
dc.date.available2012-09-05T05:15:24Z-
dc.date.issued1990en_US
dc.identifier.citationQuarterly Journal Of Medicine, 1990, v. 75 n. 278, p. 597-605en_US
dc.identifier.issn0033-5622en_US
dc.identifier.urihttp://hdl.handle.net/10722/161838-
dc.description.abstractThirty-seven Chinese patients fulfilling the criteria for Wilson's disease seen during a 35-year period were reviewed. Males and females were equally affected. Twenty-two patients were symptomatic and 15 asymptomatic; most of them presented before the third decade. Thirty-one per cent of the relatives screened showed evidence of disease, and parents were rarely affected (13 per cent). Half of the adult symptomatic females presented with primary amenorrhoea. Liver laboratory test were abnormal in only 50 per cent of patients, with γ-glutamyl-transpeptidase being the most sensitive index. Renal disease was infrequent. Serum caeruloplasmin level was the single biochemical parameter of prognostic significance (p = 0.0001). Seventy per cent of the symptomatic patients showed an improvement after treatment with penicillamine.en_US
dc.languageengen_US
dc.relation.ispartofQuarterly Journal of Medicineen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAlkaline Phosphatase - Blooden_US
dc.subject.meshCeruloplasmin - Analysisen_US
dc.subject.meshChilden_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatolenticular Degeneration - Blood - Ethnology - Genetics - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver - Pathologyen_US
dc.subject.meshMaleen_US
dc.titleWilson's disease: 35 Years' experienceen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2217665-
dc.identifier.scopuseid_2-s2.0-0025306538en_US
dc.identifier.volume75en_US
dc.identifier.issue278en_US
dc.identifier.spage597en_US
dc.identifier.epage605en_US
dc.identifier.isiWOS:A1990DM82700006-
dc.identifier.scopusauthoridLau, JYN=7402446047en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridWu, PC=7403119323en_US
dc.identifier.scopusauthoridPan, HYM=7403294798en_US
dc.identifier.scopusauthoridLin, HJ=7405571292en_US
dc.identifier.scopusauthoridTodd, D=7201388182en_US

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