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Article: Long-term results following 131I treatment for Graves' disease in Hong Kong Chinese - Discriminant factors predicting hypothyroidism

TitleLong-term results following 131I treatment for Graves' disease in Hong Kong Chinese - Discriminant factors predicting hypothyroidism
Authors
Issue Date1990
Citation
Quarterly Journal Of Medicine, 1990, v. 76 n. 281, p. 961-967 How to Cite?
AbstractThe clinical outcome of 1028 Hong Kong Chinese patients with Graves' disease treated with radioiodine therapy and followed for a mean of 9.85 ± 4.84 years (range 2-20) was analysed. Retreatment was required by 413 patients (40.2 per cent), with 134 patients (13.0 per cent) requiring more than two 131I doses. One hundred and eighty-nine patients received carbimazole after 131I until euthyroidism was achieved. The cumulative incidence of hypothyroidism at one, five, 10 and 15 years was 9.6 per cent, 31.4 per cent, 53.8 per cent and 65.8 per cent, respectively. The average incidence of hypothyroidism after the first two years was 3.3 per cent per annum. Stepwise logistic regression analysis of pretreatment variables suggested that a combination of adjunctive carbimazole therapy, absence of ophthalmopathy and longer effective half-lives of 131I were of value in predicting which patients were less likely to develop permanent hypothyroidism. However, the probability of accurately predicting permanent hypothyroidism based on the present model was only 60 per cent. We believe that no single pretreatment variable, or combination of variables, predicts long-term hypothyroidism with sufficient confidence to justify the use of a 'formula' approach for prescribing 131I therapy for Graves' disease.
Persistent Identifierhttp://hdl.handle.net/10722/161832
ISSN
1998 Impact Factor: 2.244
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKung, AWCen_US
dc.contributor.authorPun, KKen_US
dc.contributor.authorLam, KSen_US
dc.contributor.authorChoi, Pen_US
dc.contributor.authorWang, Cen_US
dc.contributor.authorYeung, RTTen_US
dc.date.accessioned2012-09-05T05:15:22Z-
dc.date.available2012-09-05T05:15:22Z-
dc.date.issued1990en_US
dc.identifier.citationQuarterly Journal Of Medicine, 1990, v. 76 n. 281, p. 961-967en_US
dc.identifier.issn0033-5622en_US
dc.identifier.urihttp://hdl.handle.net/10722/161832-
dc.description.abstractThe clinical outcome of 1028 Hong Kong Chinese patients with Graves' disease treated with radioiodine therapy and followed for a mean of 9.85 ± 4.84 years (range 2-20) was analysed. Retreatment was required by 413 patients (40.2 per cent), with 134 patients (13.0 per cent) requiring more than two 131I doses. One hundred and eighty-nine patients received carbimazole after 131I until euthyroidism was achieved. The cumulative incidence of hypothyroidism at one, five, 10 and 15 years was 9.6 per cent, 31.4 per cent, 53.8 per cent and 65.8 per cent, respectively. The average incidence of hypothyroidism after the first two years was 3.3 per cent per annum. Stepwise logistic regression analysis of pretreatment variables suggested that a combination of adjunctive carbimazole therapy, absence of ophthalmopathy and longer effective half-lives of 131I were of value in predicting which patients were less likely to develop permanent hypothyroidism. However, the probability of accurately predicting permanent hypothyroidism based on the present model was only 60 per cent. We believe that no single pretreatment variable, or combination of variables, predicts long-term hypothyroidism with sufficient confidence to justify the use of a 'formula' approach for prescribing 131I therapy for Graves' disease.en_US
dc.languageengen_US
dc.relation.ispartofQuarterly Journal of Medicineen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGraves Disease - Radiotherapyen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshHypothyroidism - Etiologyen_US
dc.subject.meshIncidenceen_US
dc.subject.meshIodine Radioisotopes - Adverse Effects - Therapeutic Useen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrognosisen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshThyroid Gland - Radiation Effectsen_US
dc.titleLong-term results following 131I treatment for Graves' disease in Hong Kong Chinese - Discriminant factors predicting hypothyroidismen_US
dc.typeArticleen_US
dc.identifier.emailKung, AWC:awckung@hku.hken_US
dc.identifier.emailLam, KS:ksllam@hku.hken_US
dc.identifier.authorityKung, AWC=rp00368en_US
dc.identifier.authorityLam, KS=rp00343en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2236479-
dc.identifier.scopuseid_2-s2.0-0025195174en_US
dc.identifier.volume76en_US
dc.identifier.issue281en_US
dc.identifier.spage961en_US
dc.identifier.epage967en_US
dc.identifier.isiWOS:A1990DZ91200007-
dc.identifier.scopusauthoridKung, AWC=7102322339en_US
dc.identifier.scopusauthoridPun, KK=7006538877en_US
dc.identifier.scopusauthoridLam, KS=8082870600en_US
dc.identifier.scopusauthoridChoi, P=7102909162en_US
dc.identifier.scopusauthoridWang, C=7501631357en_US
dc.identifier.scopusauthoridYeung, RTT=7102833337en_US

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